Neutrophil-lymphocyte ratio in catatonia

There is growing evidence of subclinical inflammation in mental disorders. Objective: The aim of this study was to investigate frequency of symptoms of catatonia and the newly diagnosed subclinical inflammatory markers which are neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), monocyte/lymphocyte (MLR) ratios in catatonia patients due to mental disorders. Methods: Patients who were admitted to psychiatry clinic with the diagnosis of catatonia according to DSM 5 in the last two years and equal number of control group were included in this retrospective study. Univariate analysis of covariance controlled for possible confounders was used to compare NLR, PLR, MLR ratios between patients and the control group. Results: A total of 34 catatonia patients and 34 healthy controls were included in the study. Patients’ mean age was 30.88 + 13.4. NLR value was significantly higher in the patient group than control group. There was no significant difference between the patients and control group according to PLR, MLR values. Discussion: The presence of subclinical inflammation in catatonic syndrome due to mental disorders should be considered. Subclinical inflammation that was observed in numerous mental disorders continues in catatonia due to mental disorders. Large-scale studies are needed to determine the role of inflammation in catatonia

Şizofrenide Psikojenik Polidipsi için Amisülpirid Tedavisi: Olgu Sunumu

Psikojenik polidipsi veya kendiliğinden indüklenen su zehirlenmesi, kompulsif su içimini tanımlamak için kullanılır. Mental hastalıklarda nadir görülen bir durum değildir. En sık kronik şizofrenide görülür. Tedavisi etiyolojiye ve tablonun ciddiyetine göre düzenlenir. Hafif vakalarda su kısıtlaması ve hastanın eğitimi yeterlidir, ağır olgularda tedavide su kısıtlaması, tuz solüsyonu infüzyonu, diüretikler, hiponatremi kaynaklı nöbetlerin kontrolünün sağlanması için antikonvülsan ilaç uygulaması yapılır. Akut klinik tablonun tedavisinden sonra altta yatan primer psikiyatrik hastalığın tedavisi yeniden düzenlenmelidir. Bu yazıda şizofreni tanısıyla 14 yıldır takip edilen ve psikojenik polidipsi tanısı alan ve amisülpirid tedavisi ve sıvı kısıtlaması ile başarıyla tedavi edilen 39 yaşında bir erkek hasta sunulmuştur

Effects of electroconvulsive therapy on nitrosative stress and oxidative DNA damage parameters in patients with a depressive episode

Background Few studies have investigated the relationship between electroconvulsive therapy (ECT) and markers of nitrosative stress and oxidative DNA damage. Objective The aim of this study is to examine changes in nitrosative stress and oxidative DNA damage in patients with a depressive episode treated with ECT. Methods The current study included 48 patients with a depressive episode treated with ECT and 30 healthy control participants. First, the serum nitrosative stress markers of nitric oxide (NO center dot), nitric oxide synthase (NOS), and peroxynitrite (ONOO-) and the oxidative DNA damage marker 8-hydroxy-2 '-deoxyguanosine (8-OHdG) were compared between the study and control groups. These parameters were also compared pre- and post-treatment for the study group. Results NO center dot, NOS, and ONOO- levels were significantly higher in patients with depressive disorder (DD) than in the control group. NO center dot and NOS levels significantly decreased in the ECT group after treatment while 8-OHdG levels significantly increased. Conclusions The study findings suggest that ECT may have reduced nitrosative stress levels while increasing oxidative DNA damage. More research is now needed to better understand the issue