Methidathion-induced hematological, biochemical and hepatohistological alterations in rat: Ameliorative effects of selenium and zinc

The aim of this study was to determine the effect of a sub-acute 4-week exposure to methidathion (MD) on the hematological system and hepatic integrity of rats. We also assessed whether co-administration of micronutrients such as selenium (Se) and zinc (Zn) prevented MD-induced hepatic damage. Rats were randomly divided into four groups of six each: the first group served as a control which received standard diet, the second group received both Se (0.5mg/kg of diet) and Zn (0.227 g/l drinking water), the third group received only MD (5 mg/kg b.w. by gavage using corn oil as a vehicle), and the fourth group received MD and combined selenium and zinc. After four weeks, exposure to MD induced a significant increase in plasmatic activities of AST, ALT, ALP, LDH, and liver malondialdehyde level. In contrast, reduced glutathione level (GSH), and the activities of catalase (CAT), superoxide dismutase (SOD), and the glutathione peroxidase (GPx) content of hepatic tissue decreased significantly. Moreover, treatment with Se and Zn in MD-treated rats maintained all the biochemical parameters cited above. In conclusion, the obtained results indicate the ability of Se and Zn to attenuate the MD-induced liver and erythrocytes oxidative damage.Key words: Biochemical studies, liver, methidathion, oxidative stress, rat, selenium, zinc

Front Neurosci

Background: Anxiety is common in patients with cognitive impairment and dementia. However, whether anxiety is a risk factor for dementia is still not known. We aimed to examine the association between trait anxiety at baseline and the 10-year risk of incident dementia to determine to which extent depressive symptoms influence this relationship in the general population. Methods: Data came from 5,234 community-dwelling participants from the Three-City prospective cohort study, aged 65 years at baseline and followed over 10 years. At baseline, anxiety trait was assessed using the Spielberger State-Trait Anxiety Inventory (STAI), and depressive symptoms using Center for Epidemiologic Studies-Depression Scale (CESD). Use of anxiolytic drugs was also considered. Diagnoses of dementia were made at baseline and every 2 years. To examine the relationship between anxiety exposures and risk of incident dementia, Cox proportional hazard regression models were performed. Results: Taking anxiolytic drugs or having high trait anxiety (STAI score >/= 44) increased the risk of dementia assessed over 10 years of follow-up [Hazard Ratio (HR) = 1.39, 95%CI: 1.08-1.80, p = 0.01 and HR = 1.26, 95%CI: 1.01-1.57, p = 0.04, respectively], independently of a large panel of socio-demographic variables, health behaviors, cardio-metabolic disorders, and additional age-related disorders such as cardiovascular diseases, activity limitations, and cognitive deficit. However, the associations were substantially attenuated after further adjustment for depressive symptoms. Conclusion: Our findings suggest that depressive symptoms shape the association between anxiety trait and dementia. Further research is needed to replicate our findings and extrapolate our results to anxiety disorders

‘This In-Between’: How Families Talk about Death in Relation to Severe Brain Injury and Disorders of Consciousness

These comments encapsulate some common themes in how people describe having a severely brain-injured relative in a coma-like condition, medically known as a ‘disorder of consciousness’. In the past it was highly unusual for such individuals to survive very long after the initial trauma that caused their injury. However, the emergence of modern medical technologies, and how they are deployed, has led to the creation of new long-term conditions including the ‘vegetative state’ (in which the patient shows no awareness at all) and the ‘minimally conscious state’ (in which the the patient displays some intermittent and minimal awareness). These conditions are modern phenomena — the vegetative diagnostic category was first created in the early 1970s (Jennett and Plum, 1972) and the ‘minimally conscious state’ [MCS] was only defined in 2002 (Giacino et al., 2002). Patients with disorders of consciousness disrupt previous ways of understanding life. The family may experience their vegetative or minimally conscious relative as ‘present but absent’, ‘living, but dead’, making comments such as ‘this is no life’ and ‘my son is gone’ — and experiencing a sense of loss and grief that may be ‘like a death’, although not a death

Experimental Investigation and Failure Analysis of Fastened GRP under Bending Using Finite Element Method and Artificial Neural Networks

This paper presents a novel approach that predicts the strength and failure modes of jointed Glass Reinforced Polyester (GRP) samples under bending using Finite Element Method (FEM) and Artificial Neural Network (ANN). The mechanical behavior of fastened glass fiber reinforced plastics composites under bending have been experimentally investigated. Samples were obtained from Amiantit Oman, a manufacturing company operating in Russail Industrial Zone in the Sultanate of Oman. The experimental program involved the conduct of three point bending tests as well as bending tests of mechanically fastened joints under static loads. The experimental results showed that the dimensions of the specimen such as the bending span length, specimen width, and specimen pitch affect GRP strength and stiffness. FEM and ANN results predicted accurately the types of failure modes and their locations along the specimens and compared well with the experimental results

Optimization of Cement–Rubber Composites for Eco-Sustainable Well Completion: Rheological, Mechanical, Petrophysical, and Creep Properties

To ensure well integrity, wellbore must be strongly cased using durable cement slurries with essential additives during downhole completion. The rubber materials that come from industrial waste are becoming extremely encouraged in the use as an additive in preparing cement slurries due to their growing environmental footprint. However, the proper design of cement slurry strongly depends on its rheological, mechanical, petrophysical, and creep properties, which can be altered by changing additives. This study aimed to examine the cement properties under alteration in different chemical admixtures to create efficient binding properties, and to estimate the optimum cement–rubber slurry composition for eco-sustainable completion. Three cement samples with different mesh sizes of the crumb rubber particles were prepared. This study examined the variation in rheological behaviors, elastic and failure characteristics, permeability, and creep behavior of the cement–rubber composites for petroleum well construction. The experimental study showed that the addition of 15% or more crumb rubber to the cement resulted in very thick slurries. Moreover, it was shown that the addition of crumb rubber with various particle sizes to the cement reduced the strength by more than 50%, especially for a higher amount of rubber added. It was also revealed that the addition of a superplasticizer resulted in an 11% increase in compressive strength. The results showed that cement–crumb-rubber composites with 12% by weight of cement (BWOC) represented the optimum composite, and considerably improved the properties of the cement slurry. Water-permeability tests indicated the addition of 12% BWOC with 200-mesh crumb rubber decreased the permeability by nearly 64% compared to the base cement. Creep tests at five different stress levels illustrated that the neat cement was brittle and did not experience strain recovery at all stress levels. Cement slurries with the largest rubber-particle size were elastic and demonstrated the highest amount of strain recovery. Finally, a relationship was established between the permeability, average strain, and mesh size of the rubber particles, which offered the strain recovery, satisfied the zonal isolation, and consequently reduced the microannulus problem to ensure the cement’s integrity

Optimization of Cement–Rubber Composites for Eco-Sustainable Well Completion: Rheological, Mechanical, Petrophysical, and Creep Properties

To ensure well integrity, wellbore must be strongly cased using durable cement slurries with essential additives during downhole completion. The rubber materials that come from industrial waste are becoming extremely encouraged in the use as an additive in preparing cement slurries due to their growing environmental footprint. However, the proper design of cement slurry strongly depends on its rheological, mechanical, petrophysical, and creep properties, which can be altered by changing additives. This study aimed to examine the cement properties under alteration in different chemical admixtures to create efficient binding properties, and to estimate the optimum cement–rubber slurry composition for eco-sustainable completion. Three cement samples with different mesh sizes of the crumb rubber particles were prepared. This study examined the variation in rheological behaviors, elastic and failure characteristics, permeability, and creep behavior of the cement–rubber composites for petroleum well construction. The experimental study showed that the addition of 15% or more crumb rubber to the cement resulted in very thick slurries. Moreover, it was shown that the addition of crumb rubber with various particle sizes to the cement reduced the strength by more than 50%, especially for a higher amount of rubber added. It was also revealed that the addition of a superplasticizer resulted in an 11% increase in compressive strength. The results showed that cement–crumb-rubber composites with 12% by weight of cement (BWOC) represented the optimum composite, and considerably improved the properties of the cement slurry. Water-permeability tests indicated the addition of 12% BWOC with 200-mesh crumb rubber decreased the permeability by nearly 64% compared to the base cement. Creep tests at five different stress levels illustrated that the neat cement was brittle and did not experience strain recovery at all stress levels. Cement slurries with the largest rubber-particle size were elastic and demonstrated the highest amount of strain recovery. Finally, a relationship was established between the permeability, average strain, and mesh size of the rubber particles, which offered the strain recovery, satisfied the zonal isolation, and consequently reduced the microannulus problem to ensure the cement’s integrity