2,773 research outputs found
Rheology Of Cement Paste Containning Chemical Admixtures
Understanding the Rheology of cement and water is a not a simple task since, thebehaviour of complicated system varies with time and there is still a great deal of work to bedone before, it is properly understood. In this study, we used a new simple and cheaptechnique to evaluate flow properties of cement paste .This technique is based on dropping aneedle from a constant height. The penetration depth is measured at different circumstances,different w/c ratios, different types of super plasticizer, and different percentage of admixturefor two types of cement types of cements OPC type V (CEMEX) and OPC type I (HELWAN)were considered in this study. Also, effect of retempering on penetration depth were alsoconsidered. Finally effect of variation of needle drop height was also considered. Thepenetration depth technique proved to be effective in monitoring the effect ofsuperplasticizer/cement ratio percentage, effect of time, manual remixing after 30 minutesand needle drop height on the rheological behavior of different types of cement paste, whichfurther proves the effectiveness of this method in evaluation of cement paste Rheology
Characterization of OPC Matrix Containing Dealuminated Kaolin
The suitability of replacing Portland cement by dealuminated calcined kaolin as received waste obtained from an alum production factory through the extraction of aluminium, also by dealuminated samples treated with lime solution, is investigated. The chemical and mineralogical compositions of the samples are measured. Their pozzolanic reactivity and their surface areas were determined. The effect of replacement on setting time, flowability, rate of flowability loss and strength of mortars was tested and compared to control OPC samples and others containing silica fumes. It was found that the as received dealuminated kaolin and that treated with lime possess higher pozzolanic reactivity and show larger surface areas than silica fumes. The incorporation of the as received dealuminated kaolin (DK) in OPC paste accelerates the setting time; while the lime-treated samples lead to retardation. The flowability of the OPC mortar is little affected by the as received DK samples and is strongly reduced by the lime-treated one and silica fumes. The three admixtures cause strong flowability loss with time. The 56d-compressive and tensile strengths of the mortars improve with 5 and 10% OPC replacement by DK
Measurement of the inclusive jet cross-section in pp collisions at √s=2.76 TeV and comparison to the inclusive jet cross-section at √s=7 TeV using the ATLAS detector
The inclusive jet cross-section has been measured in proton–proton collisions at √s=2.76 TeV in a dataset corresponding to an integrated luminosity of 0.20 pb−1 collected with the ATLAS detector at the Large Hadron Collider in 2011. Jets are identified using the anti-kt algorithm with two radius parameters of 0.4 and 0.6. The inclusive jet double-differential cross-section is presented as a function of the jet transverse momentum pT and jet rapidity y, covering a range of 20≤pT<430 GeV and |y|<4.4. The ratio of the cross-section to the inclusive jet cross-section measurement at √s=7 TeV, published by the ATLAS Collaboration, is calculated as a function of both transverse momentum and the dimensionless quantity xT=2pT/√s, in bins of jet rapidity. The systematic uncertainties on the ratios are significantly reduced due to the cancellation of correlated uncertainties in the two measurements. Results are compared to the prediction from next-to-leading order perturbative QCD calculations corrected for non-perturbative effects, and next-to-leading order Monte Carlo simulation. Furthermore, the ATLAS jet cross-section measurements at √s=2.76 TeV and √s=7 TeV are analysed within a framework of next-to-leading order perturbative QCD calculations to determine parton distribution functions of the proton, taking into account the correlations between the measurements
CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse
We examined the potential value of the natural killer (NK) cell line; NK-92, as immunotherapy tool for breast cancer (BC) treatment and searched for biomarker(s) of sensitivity to NK-92-mediated cytotoxicity. The cytotoxic activity of NK-92 cells towards one breast precancerous and nine BC cell lines was analyzed using calcein-AM and degranulation assays. The molecules associated with NK-92-responsiveness were determined by differential gene expression analysis using RNA-sequencing and validated by RT-PCR, immunostaining and flow cytometry. NK-target interactions and immunological synapse formation were assessed by fluorescence microscopy. Potential biomarker expression was determined by IHC in 99 patient-derived BC tissues and 10 normal mammary epithelial tissues. Most (8/9) BC cell lines were resistant while only one BC and the precancerous cell lines were effectively killed by NK-92 lymphocytes. NK-92-sensitive target cells specifically expressed CD56, which ectopic expression in CD56-negative BC cells induced their sensitivity to NK-92-mediated killing, suggesting that CD56 is not only a biomarker of responsiveness but actively regulates NK function. CD56 adhesion molecules which are also expressed on NK cells accumulate at the immunological synapse enhancing NK-target interactions, cytotoxic granzyme B transfer from NK-92 to CD56-expressing target cells and induction of caspase 3 activation in targets. Interestingly, CD56 expression was found to be reduced in breast tumor tissues (36%) with strong inter- and intratumoral heterogeneity in comparison to normal breast tissues (80%). CD56 is a potential predictive biomarker for BC responsiveness to NK-92-cell based immunotherapy and loss of CD56 expression might be a mechanism of escape from NK-immunity. - 2019, The Author(s).We would like to thank Ms Khaoula Errafii, Dr Kumaran Mande and Dr Richard Thompson for technical support in RNA sequencing. This work was supported by the Qatar Biomedical Research Institute (QBRI), Qatar Foundation.Scopu
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Digital trio: integration of BIM–EIR–IoT for facilities management of mega construction projects
Facility Management (FM) has increasingly focused on integrating Building Information Modeling (BIM) with the Internet of Things (IoT), known as digital twins, in large-scale development projects. Effective BIM integration in FM requires improved cooperation among participants across various project stages. This digital revolution aims to enhance planning, construction, and asset management efficiency, benefiting all parties. However, BIM utilization in FM is limited by incomplete owner understanding, insufficient data accessibility, and stakeholders’ unfamiliarity with BIM procedures and standards. Despite recognizing BIM’s significance, the FM industry faces significant implementation challenges. Facility managers often lack a comprehensive understanding of BIM’s benefits in streamlining operations and enhancing cost efficiency, as well as the necessary skills for its use. Addressing these barriers requires developing an Employer’s Information Requirements (EIR) document at a project’s outset, providing a strategic plan and vision for all involved parties. BIM and IoT are pivotal technologies for transitioning to efficient building operations and crucial for reducing time, costs, and operational challenges throughout any project. This research aims to establish a digital trio workflow, integrating BIM, EIR, and IoT to maximize stakeholder benefits. It explores how preparing the EIR through stakeholder communication can improve design processes, sustainability, efficiency, cost, and time, especially for megaprojects
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Developing standard BIM execution plans for complex construction projects
This study addresses the critical need for standardizing building information modeling (BIM) execution plans (BEPs) in the architecture, engineering, construction, and operations (AECO) sector. Through the analysis of 36 BEP documents from international organizations, we have identified crucial components and put forth a comprehensive framework with the objective of improving digital transformation and collaboration in intricate construction projects. This study utilizes scientometric analysis to chart the development of BEP standards and incorporates empirical data from industry surveys to verify the suggested framework. The results of our research emphasize the advantages of using standardized building execution plans (BEPs) to decrease inefficiencies and enhance project outcomes. This makes a substantial contribution to the field of building information modeling (BIM) implementation
Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
Background Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels and trends of global meningitis burden that could help to guide introduction, continuation, and ongoing development of vaccines and treatment programmes.AA received funding from Department of Science and
Technology, Government of India, New Delhi, through INSPIRE
Faculty Award Scheme. HB was financially supported by Mazandaran
University of Medical Sciences, Sari, Iran. AB received support for
research from the Project of Ministry of Education, Science and
Technology of the Republic of Serbia (No. III45005). TWB was
supported by the Alexander von Humboldt Foundation through the
Alexander von Humboldt Professor award, funded by the Federal
Ministry of Education and Research. FC reports European Union
(FEDER funds POCI/01/0145/FEDER/007728 and POCI/01/0145/
FEDER/007265) and National Funds (FCT/MEC, Fundação para a
Ciência e a Tecnologia and Ministério da Educação e Ciência) under the
Partnership Agreements PT2020 UID/MULTI/04378/2013 and PT2020
UID/QUI/50006/2013. HF was financially supported by Urmia
University of Medical sciences, Urmia, Iran. EF reports European
Union (FEDER funds POCI/01/0145/FEDER/007728 and
POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC,
Fundação para a Ciência e a Tecnologia and Ministério da Educação e
Ciência) under the Partnership Agreements
PT2020 UID/MULTI/04378/2013 and PT2020 UID/QUI/50006/2013.
JK has received research funding from Merck Pharmaceuticals. AM
acknowledges that Imperial College London is grateful for support
from the NW London National Institute of Health and Research
Collaboration for Leadership in Applied Health Research and Care.
UOM acknowledges funding from the German National Cohort Study
Federal Ministry of Education and Research Grant #01ER1511/D. AMS
was supported by a fellowship from the Egyptian Fulbright Mission
Program. MSM acknowledges the support from the Ministry of
Education, Science and Technological Development, Republic of Serbia
(Contract No. 175087). KBT acknowledges funding supports from the
Maurice Wilkins Centre for Biodiscovery, Cancer Society of New
Zealand, Health Research Council, Gut Cancer Foundation, and the
University of Auckland. CSW’s work is funded by the South African
Medical Research Council and the National Research Foundation of
South Africa (Grant Numbers: 106035 and 108571)
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