The Impact of Information Asymmetry on the Relationship Between Board Characteristics and Capital Structure

This paper explores the role of information asymmetry in the association between board characteristics and capital structure using OLS & GMM for 96 firms listed on the Egyptian stock exchange with 672 firmobservation through the period 2014–2020 via the Thomson Reuters database. Results show that a large board size enhances strict control and forces increased debts to maximize firm value and higher board independence leads to the tendency to use less financial leverage to avoid raising risks. CEO duality leads to the use of small amounts of debt to avoid pressures and risks. Results show that Firms with high information asymmetry prefer high leverage. Finally, results clarified that board characteristics hurt capital structure in the case of countries that suffer from information asymmetry like Egypt

病巣内切除後の腫瘍増殖能に関する研究 : T-saw,Gigli sawおよびメスによる比較研究

取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1516号 , 学位授与年月日 : 平成14年3月22日, 学位授与大学 : 金沢大

Preoperative gemcitabine based chemo-radiotherapy in locally advanced non metastatic pancreatic adenocarcinoma

<p>Abstract</p> <p>Introduction</p> <p>Almost 30% of patients with pancreatic cancer have locally advanced tumours in absence of distant metastasis. Surgical resection is often contraindicated. The combination of gemcitabine with concurrent radiation therapy is a promising new approach that is being investigated for treating patients' unresectable pancreatic cancer. This work aims at assessing the efficacy of preoperative gemcitabine based chemo-radiotherapy in increasing the resectability rate for patients' locally advanced pancreatic cancer.</p> <p>Patients and methods</p> <p>From March 2006 to November 2007, 25 patients with locally advanced non metastatic pancreatic cancer were treated by preoperative gemcitabine based chemo-radiotherapy. The radiation dose was 54 Gray in 30 fractions over 6 weeks prescribed to the isocenter. Gemcitabine (300 mg/m2) was given through a 30 minute intravenous infusion. This was done 30 minutes before the radiation sitting on a weekly basis throughout the radiotherapy course.</p> <p>Approximately 6 weeks after the completion of chemo radiation, an evaluation was performed regarding tumour response and resectability as well as acute toxicity. Pancreaticoduodenectomy was performed for operable patients with surgical reconstruction.</p> <p>Results</p> <p>Patients who achieved complete resection (CR) numbered 2 (8%), while those achieving partial resection (PR) totalled 11 (44%); six of these patients were considered ro be operable. Thus Pancreaticoduodenectomy was performed on 8 patients (2 with CR and 6 with PR) with surgical reconstruction. Patients who had a stable disease numbered 4 (16%), and those with progressive diseases included a group of eight (32%). The postoperative 30 day mortality occurred only in one patient (12.5%). Acute toxicity of chemoradiation occurred in the form of grade I leucopoenia and thrombocytopenia. Hepatic toxicity, nausea, and vomiting were found in 8 patients (32%), 10 patients (40%) and 4 patients (16%), respectively. The postoperative 30 day mortality occurred only in 1 patient. Also, minor biliary leakage and leakage from gastrointestinal anaestomosis both occurred in a single patient. Out of the 8 patients who underwent radical surgical resection, only one developed local recurrence and simultaneous liver metastasis during the follow up period. The median survival of all patients was 12 months.</p> <p>Conclusion</p> <p>Preoperative gemcitabine based chemoradiation might benefit patients with locally advanced non metastatic pancreatic cancer by increasing the resectability without significant acute toxicity.</p

Review Multi Pass Friction Stir Processing

The aim of this article is to provide a review of multiple passes friction stir processing technology and their effect on the microstructure refinement, improving mechanical properties furthermore enhancement of reducing distortion and defects in materials. Multi-pass FSP achieves uniform dispersion of reinforcement particles in the metal matrix composites. The present paper reviews the work done in the above mentioned areas and concludes the effect of multi-pass FSP on the mechanical properties

The nature of fibrous dysplasia

Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption

脊椎全摘出における脊柱再建

金沢大学医学部附属病院リハビリテーション部学会抄

SELECTION FOR HIGH AND LOW POST-WEANING GAIN AMONG INBRED AND OUTBRED STOCKS OF RATS UNDER THYROPROTEIN AND THIOURACIL TREATMENT

Abstract not availabl