Time expenditure differences among weekdays, weekends, and fridays for residents of Makkah, Kingdon of Saudi Arabia

Many researchers have studied the differences in travel behaviours during the weekdays and the weekends for building travel demand in Makkah, Saudi Arabia, any travel demand framework should recognize the differences in residents' travel behaviour not only between the weekdays and the weekends, but also on Fridays. During the weekends (i.e., Thursday and Friday), most residents spend time with their families and friends on Thursdays, whereas some go to work. On Fridays, there is the Friday prayer, which takes place around noon, and most of the stores are closed until late afternoon. This paper presents modelling of the activity duration for residents of the city of Makkah for weekdays and weekends. The municipality of Makkah collected a full-day travel diary for the residents of Makkah in 2010 for all days of the week. The data were categorized as either weekdays or weekends. Then the multiple discrete continuous extreme value (MDCEV) model was used to estimate the activity duration for 3 separate groups of days (i.e., weekdays, Thursdays, and Fridays), and a fourth model was estimated for all days of the week. This paper will highlight the differences in travel behaviour for the residents of Makkah between the weekdays and the weekends time periods. The outcomes of this paper could be expanded for use in Muslim communities and for all other religions that perform religious rituals during the weekends

‘Poly phenolic phytoceutical loaded nano-bilosomes for enhanced caco-2 cell permeability and SARS-CoV 2 antiviral activity’: in-vitro and insilico studies

AbstractSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) predisposed to the emergence of worldwide catastrophe that impels the evolution of safe and effective therapeutic system. Polyphenols as resveratrol (RSV) exhibit a well evidenced antiviral activity. Unfortunately, like most phenolic nutraceuticals, RSV suffers from restrained solubility and massive degradation in GIT and liver which in turn prohibit its clinical use. Herein, PEGylated bilosomes (PBs) contain PEGylated edge activator along with the traditional components as (Span 60, cholesterol and bile salts) were proposed to boost both permeability and bioavailability of RSV. The investigation of the prominent effect of the diverse variables on the characteristics of the vesicles and picking of the optimum formula were conducted via construction of 23 factorial experiment. The appraisal of the formulae was conducted on the basis of entrapment efficiency percent (EE%), particle size (PS) and zeta potential (ZP). In addition, the spherical shaped optimal formula (F5) exhibited EE% of 86.1 ± 2.9%, PS of 228.9 ± 8.5 nm, and ZP of −39.8 ± 1.3 mV. The sorted optimum formula (F5) exhibited superior dissolution behaviors, and boosted Caco-2 cells cellular uptake by a round 4.7 folds relative to RSV dispersion. In addition, F5 demonstrated a complete in vitro suppression of SARS-CoV-2 at a concentration 0.48 μg/ml with 6.6 times enhancement in antiviral activity relative to RSV dispersion. The accomplished molecular modeling heavily provided proof for the possible interactions of resveratrol with the key residues of the SARS-CoV2 Mpro enzyme. Finally, F5 could be proposed as a promising oral panel of RSV for curation from SARS-CoV-2 infection