The effect of sulfoxo-bilactam-21-crown -7 on spermatogenesis in immature Balb/c mice

زمینه و هدف: کراون اترها ملکول های میزبان برای یون های فلزی و غیر فلزی هستند. توانایی کراون اترها در کنترل سیکل و تغییر فعالیت برخی از آنزیم ها گزارش شده است. در این مطالعه اثر یک کراون اتر جدید (سولفوکسو- بی لاکتام- 21- کراون-7) بر روی بافت بیضه و اسپرماتوژنز مورد بررسی قرار گرفته است. روش بررسی: در این مطالعه 24 سر موش نابالغ کوچک آزمایشگاهی (Balb/C) به سه گروه گروه کنترل (هیچ ماده ای دریافت نکردند)، شم )فقط توئین 80 دریافت کردند) و تجربی )سولفوکسو- بی لاکتام- 21- کراون-7 دریافت کردند) تقسیم شدند. Lethal dose 50 (LD50) دارو، به میزان 40 میلی گرم بر کیلوگرم تعیین شد. بر این اساس، دوز 20 میلی گرم بر کیلوگرم از این کراون اتر به روش درون صفاقی هر روز به مدت یک هفته به گروه تجربی تزریق شد. دو هفته پس از آخرین تزریق، حیوانات بیهوش شده و کشته شدند. خون جهت اندازه گیری هورمون از قلب گرفته شد. بافت بیضه، استخراج شد و جهت مطالعات بافت شناسی فیکس گردید. داده ها توسط آنالیز واریانس یکطرفه (ANOVA) و به دنبال آن تست توکی آنالیز شدند. یافته ها: تزریق درون صفاقی سولفوکسو- بی لاکتام- 21- کراون-7 (20 میلی گرم بر کیلوگرم) تغییر معنی داری در تعداد اسپرماتوگنی نوع A و B، اسپرماتوسیت اولیه و سلول های لیدیک در گروه تجربی در مقایسه با گروه کنترل و شم نشان نداد. افزایش هورمون جنسی مردانه، تستوسترون (001/0

BINOL Macrocycle Derivatives: Synthesis of New Dinaphthyl Sulfide Aza Oxa Thia Crowns (Lariats)

In this research work, dinaphthyl sulfide diester was prepared from the reaction of 1,1′-thiobis (2-hydroxy naphthalene) and methylchloroacetate. Its aza-macrocyclic derivative was synthesized from the reaction of dinaphthyl sulfide diester and diethylenetriamine. Lariats were prepared from the reaction of chloroamides (four derivatives) and initial macrocycle. Chloroamides were synthesized from the reaction of amines (aniline, benzylamine, 8-amino quinoline and 4-amino azobenzene) and chloroacetyl chloride. All the materials were identified by IR, 1H NMR, 13C NMR, and mass spectroscopies, and elemental analysis

Microwave Assisted Selective Synthesis of four Chromanones Via Biscyclization Method in the Presence of Polyphosphoric Acid and Crystal Structure Determination of Their Dicarboxylic Acids

ABSTRACT: Microwave irradiation is used in the synthesi

The Adverse Effects of Methoxsalen on The Oogenesis of Balb/C Mice

Objective: Methoxsalen is a natural photoactive compound which is found in many seed plants. A number of epidermal proliferative disorders can be treated by methoxsalen along with long wave ultraviolet A (UVA).Materials and Methods: In an experimental study, we aimed to demonstrate the effect of methoxsalen, UVA and their combination on oogenesis Balb/C mice. There were two experimental groups and a control group. The experimental groups were composed of i. a short term group with treatment duration of 15 days and ii. a long term group with treatment duration of 5 weeks. Both the long term and short term experimental groups were further subdivided into a UVA group, a methoxsalen group and a methoxsalen plus UVA group. After treatment, mature females in prosterus phase of ovarian cycle were scarified with ether, while their ovaries were removed and prepared for histological studies.Results: Both macro and microscopic studies showed significant anomalies (p<0.05) among experimental group ovaries as compared to control group. The obtained results showed a significant decrease in the following factors: number and diameter of corpus lutei, Graafian follicles, diameter of granulosa cell layer and oocytes, number of primordial،and primary and growing follicles, while we observed an increase in number of atretic follicle. Furthermore, our findings confirmed an increase in theca diameter only through UVA treatment. Methoxsalen also reduced circulating estrogen levels in blood serum, significantly. Other cases of teratogenecity, such as follicles with three oocytes and disorganization in corpus luteum cells were observed.Conclusion: The result suggests that UVA, methoxsalen and their combination cause health problems and cell injuries

Nitro-Substituted Polyamides: A New Class of Transparent and Highly Refractive Materials

High-refractive-index polyamides (PAs) were developed by introducing nitro groups, thiazole rings, and thioether linkages. The PAs were prepared by the polycondensation of a novel diamine monomer, 5,5′-thiobis(2-amino-4-(3-nitrophenyl)thiazole) (DA), with various aromatic diacids. The bulky pendant nitrophenyl units, as well as the flexible thioether linkage in the diamine, endowed the resulting PAs with excellent solubilities in both amide-type polar aprotic solvents and less polar solvents. The obtained polymers exhibited high heat resistance, with 10% weight loss temperatures exceeding 472 °C under nitrogen and 427 °C in air atmosphere, while their glass transition temperatures were in the range 210–244 °C. The combination of the nitro substituents, thiazole units, and thioether linkages provided PAs with high refractive indices of up to 1.7660 at 632.8 nm, along with high transparency in the visible region and low birefringences (\u3c0.0081). The structure–property relationships of these PAs due to the presence of nitro groups were also studied by comparing the results with the previously reported analogous polymers

High refractive index and low-birefringence polyamides containing thiazole and naphthalene units

Highly refractive and solution processable polyamides (PAs) were synthesized by the introduction of thiazole rings, naphthalene groups, and thioether linkages. These PAs were synthesized by the polycondensation of a new diamine monomer, 5,5'-thiobis(2-amino-4-(2-naphthyl)thiazole) (DA), with various aromatic diacids. The bulky pendant naphthyl units endowed the resulting PAs with non-coplanar structures and excellent solubilities in organic solvents. The obtained PAs showed high thermal stability, with 10% weight loss temperatures exceeding 478°C under nitrogen and 431°C in air atmosphere, while their glass transition temperatures were in the range of 194-229°C. The synergic effects of the thiazole groups, naphthyl substituents, and thioether linkages provided PAs with very high refractive indices of up to 1.7701 at 632.8 nm, along with small birefringences (<0.0076) and high Abbe's numbers. The structure-property relationships of these PAs due to the presence of naphthyl substituents were also studied in detail by comparing the results with the previously reported analogous PA