Dynamics of Charged Bulk Viscous Collapsing Cylindrical Source With Heat Flux

In this paper, we have explored the effects of dissipation on the dynamics of charged bulk viscous collapsing cylindrical source which allows the out follow of heat flux in the form of radiations. Misner-Sharp formulism has been implemented to drive the dynamical equation in term of proper time and radial derivatives. We have investigated the effects of charge and bulk viscosity on the dynamics of collapsing cylinder. To determine the effects of radial heat flux, we have formulated the heat transport equations in the context of M$\ddot{u}$ller-Israel-Stewart theory by assuming that thermodynamics viscous/heat coupling coefficients can be neglected within some approximations. In our discussion, we have introduced the viscosity by the standard (non-casual) thermodynamics approach. The dynamical equations have been coupled with the heat transport equation equation, the consequences of resulting coupled heat equation have been analyzed in detail.Comment: 17 Pages, no figur

Magnetohydrodynamic Viscous Flow Over a Shrinking Sheet With Second Order Slip Flow Model

In this paper, we investigate the magnetohydrodynamic viscous flow with second order slip flow model over a permeable shrinking surface. We have obtained the closed form of exact solution of Navier-Stokes equations by using similarity variable technique. The effects of slip, suction and magnetic parameter have been investigated in detail. The results show that there are two solution branches, namely lower and upper solution branch. The behavior of velocity and shear stress profiles for different values of slip, suction and magnetic parameters has been discussed through graphs.Comment: 13 Pages, 8 Figures. Accepted for Publication in Heat Transfer Researc

Estimation of dihydroartemisinin in human plasma using a highly sensitive LTQ Orbitrap mass spectrometer with Xcalibur software

Background: Artemether (ARM), the O-methyl ether prodrug of dihydroartemisinin (DHA), is considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its active metabolite DHA, and therefore its determination offers considerable difficulties. In the present study, DHA identification and estimation were accurately performed by the mass spectrometric analysis, using a high-resolution liquid chromatography/electrospray ionization-mass spectrometry (LC/ESI-MS) LTQ Orbitrap hybrid mass spectrometer.Methods: The plasma samples were taken from healthy volunteers, and the spiked plasma was extracted by adding 1 mL of a mixture of dichloromethane and tert.-methyl butyl ether (8:2 v/v) to 0.5 mL of plasma. The internal standard solution (artemisinin 500 ng/mL) was added to the plasma samples. After vertexing and centrifugation, the organic layer was separated and transferred into another tube and dried under nitrogen. The residue was reconstituted in 100 μL of acetonitrile and was injected onto the LC-MS system for analysis. Measurement of standards and samples was carried out isocratically on a Surveyor HPLC system combined with an LTQ Orbitrap mass spectrometer using an ACE 5 C18-PFP column. Mobile phase A consisted of 0.1% v/v formic acid in water, Mobile phase B consisted of acetonitrile only, and isocratic elution was carried out with A:B 20:80, v/v. The flow rate was 500 μL/min. The ESI interface was operated in a positive ion mode with a spray voltage of 4.5 kV.Results: Artemether is not a very biologically stable compound and is immediately metabolized to its active metabolite dihydroartemisinin, so no clear peak was observed for artemether. Both artemether and DHA after ionization undergo neutral losses of methanol and water, respectively, in the source of the mass spectrometer. The ions observed were (MH-H2O) m/z 267.15 for DHA and (MH-m/z 283.15 for internal standard artemisinin. The method was validated according to international guidelines.Discussion: The validated method was applied successfully for the determination and quantification of DHA in plasma samples. This method works well for the extraction of drugs, and the Orbitrap system with the help of Xcalibur software accurately and precisely determines the concentration of DHA in spiked as well as volunteer’s plasma

Risk factors for 5-year mortality in a cohort of elderly patients with sarcopenia

Background: The association between multiple risk factors and the mortality of sarcopenic patients has not been studied. This study's aim is to report the prevalence of sarcopenia among a sample of Italian hospitalized older adults, describe the physical function, body fat composition, cognitive, inflammatory and nutritional status of sarcopenic compared with non-sarcopenic subjects, and determine the risk factors associated with mortality in sarcopenic patients. Method: A total of 462 patients were enrolled and followed up for a period of 5 years. Sarcopenia was diagnosed according to the EWGSOP2 criteria. Factors associated with sarcopenia were identified with linear regression analysis. Logistic regression was applied to explore the association between the risk factors and mortality in sarcopenic subjects. Survival analyses and predictors of mortality were identified using Kaplan-Meier and Cox regression. Results: The prevalence of sarcopenia was 33.5%. Linear regression showed that sarcopenia was associated with Barthel index (B −9.63, p0.004), BMI (B −3.19, p24.9 (HR 0.287 C95% 0.095–0.866 p 0.027). Conclusion: Sarcopenia is associated with low physical function and BMI but higher android fat. Low Barthel, BMI and albumin can significantly decrease the survival rate in sarcopenic patients. Whereas BMI >24.9 is associated with lower mortality hazard

Effect of different salinity level on spawning, fertilization, hatching and survival of common carp, Cyprinus carpio (Linnaeus, 1758) in semi-artificial environment

The effects of various salinity levels among (0‰, 5‰, 10‰, 15‰, and 20‰) for successful breeding of common carp, Cyprinus carpio were investigated. The duration of study was 75 days. Ripe broodstock (30) having a mean weight (male 1027±2.4g and female 1084.8±23g) were selected and stocked into spawning tanks (2000 L). The ratio among male and female was 2:1. They were fed with commercial floating pelleted feed having 35% crude protein with 2% body weight twice a day. Broodstock were injected with ovaprim hormone 0.5 mg kg^-1 female and male 0.2 mg kg^-1 respectively, after successful spawning broodstock were removed from spawning tanks. The results showed that the highest fecundity, fertility, hatchability and survival of fry were obtained on salinity of 0‰ to 10‰ and significantly decreased on 15‰ and 20‰. The eggs per gram body weight were also recorded in all treatments and highest eggs were obtained, i.e. 45-60 per female on salinity of 0‰-10‰. Water temperature (22.4±0.2°C), dissolved oxygen (6.5±0.2 mg L^-1), pH (7.2±0.2) and ammonia (less than 0.03±0.06 mg L^-1) were monitored throughout the study period. Water quality parameters remained within the recommended range. Our results suggest that common carp, C. carpio may give maximum eggs up to 10 ‰ salinity with 81% survival of the fry

Determination of α1-acid glycoprotein (AGP) concentration by HPLC in patients following local infiltration analgesia for primary total hip arthroplasty and its relation to ropivacaine (total and unbound)

Introduction: This study was performed to determine the levels of α1-acid glycoprotein (AGP) in old-age patients undergoing total hip arthroplasty. AGP is considered an acute phase protein produced during the acute phase reaction in the body to various stimuli; their proper monitoring is thus important.Methods: In order to study how AGP concentrations in old age patients change in response to surgical stress (total hip arthroplasty), a high-performance liquid chromatography assay was performed to measure AGP levels. AGP was isolated from the plasma by adding perchloric acid and was analyzed using PLRP-S 4000°A column. The mobile phase consisted of 1 mL TFA/L of water (Solvent A pH 2) and 1 mL TFA/L of acetonitrile (Solvent B). The gradient used was as follows: 0 min 18% B and 82% A, 15 min 60% B and 40% A, and 17 min 60% B and 40% A followed by column re-equilibration for 7 min before the next injection. AGP peak was obtained between 8.8 and 8.9 min. The method was fully optimised according to established guidelines.Results: The data obtained were analyzed on ChromQuest software. AGP concentrations were determined in all samples, including baseline and samples taken at different timed intervals. The peak for AGP was obtained between 8.8 and 8.9 min for both standard AGP and patient plasma. The graphs indicate that AGP concentration in almost all patient samples increased considerably, especially after 4 h and 24 h—for example, initial concentration in patient 1 was 10.36 mg/100 mL but, after 24 h, increased to 23.50 mg/100 mL. There was thus almost a 13 mg/100 mL increase in 24 h, which is confirmed by AGP concentration increasing after various conditions, including surgery. The increased plasma protein binding was comparatively associated with the unchanged free fraction of the drug.Conclusion: This surgically induced increase in AGP concentration resulted in increased plasma protein binding of the drug (ropivacaine), which in turn kept the free portion of ropivacaine stable during the postoperative period

A novel application of Fiber Bragg Grating (FBG) sensors in MPGD

We present a novel application of Fiber Bragg Grating (FBG) sensors in the construction and characterisation of Micro Pattern Gaseous Detector (MPGD), with particular attention to the realisation of the largest triple (Gas electron Multiplier) GEM chambers so far operated, the GE1/1 chambers of the CMS experiment at LHC. The GE1/1 CMS project consists of 144 GEM chambers of about 0.5 m2 active area each, employing three GEM foils per chamber, to be installed in the forward region of the CMS endcap during the long shutdown of LHC in 2108-2019. The large active area of each GE1/1 chamber consists of GEM foils that are mechanically stretched in order to secure their flatness and the consequent uniform performance of the GE1/1 chamber across its whole active surface. So far FBGs have been used in high energy physics mainly as high precision positioning and re-positioning sensors and as low cost, easy to mount, low space consuming temperature sensors. FBGs are also commonly used for very precise strain measurements in material studies. In this work we present a novel use of FBGs as flatness and mechanical tensioning sensors applied to the wide GEM foils of the GE1/1 chambers. A network of FBG sensors have been used to determine the optimal mechanical tension applied and to characterise the mechanical tension that should be applied to the foils. We discuss the results of the test done on a full-sized GE1/1 final prototype, the studies done to fully characterise the GEM material, how this information was used to define a standard assembly procedure and possible future developments.Comment: 4 pages, 4 figures, presented by Luigi Benussi at MPGD 2015 (Trieste, Italy). arXiv admin note: text overlap with arXiv:1512.0848

Overview of large area triple-GEM detectors for the CMS forward muon upgrade

In order to cope with the harsh environment expected from the high luminosity LHC, the CMS forward muon system requires an upgrade. The two main challenges expected in this environment are an increase in the trigger rate and increased background radiation leading to a potential degradation of the particle ID performance. Additionally, upgrades to other subdetectors of CMS allow for extended coverage for particle tracking, and adding muon system coverage to this region will further enhance the performance of CMS