The Role IgM, IgG a, Complementary Factors C3, C4 and Latex assay in C-reactive Protein Positive Assay) in Perioniditis Patients

Periodontal diseases include the common inflammatory disorders known as gingivitis and periodontitis, which are caused by microbes in the biofilms under the gums. The study aimed to identify the level of CRP, C3, C4, IgG and IgM in the serum of patients with periodontal diseases compared to its level in the healthy people. Sixty blood samples were collected from patients with Periodontal diseases , and 30 apparently healthy individuals who were considered as a control group .The current study showed that the prevalence of the disease was higher in females (n=33 ) than in males (n=27), ( 55.0% , 45.0%), respectively. As the highest rate of infection was within the age group from 30-39 years, at a rate of 36.7%, and the lowest was within 50-59 years at a rate of 3.3% .It was found through statistical analysis of the results that there are very high significant differences (p<0.001)between smoking and non-smoking patients. Chronic gingivitis had the highest prevalence rate of 51.7%, among other types. The results of the study also indicated that the CRP positivity in patients with Periodontal diseases was 68.3% and negative 31.7% . That the level of C3 and C4 in the sera of patients ,increased significantly P value (0.001,0.004) respectively, compared to its level in the sera of healthy subjects, where the mean ± standard deviation was [( 208.78 ± 55.40 and 138.67 ± 39.69);(43.65 ± 10.80 and 30.03 ± 9.81)] mg/dl, respectively. It was observed from the results of the study that the level of the IgM and IgG immunoglobulin of the patients had a very high significant increase (p <0.001) ,compared to the healthy group, [(228.37 ± 42.83 and 147.33 ± 13.86);(169.72 ± 68.32)] mg / dl, respectively

Evaluation Of the Immunopatho Role Of Interleukins IL17, IL21,and CD4+,CD8+ T cells In Patients With Type 1 Diabetes In The City of Baquba

Background: Diabetes Mellitus (DM) is a heterogeneous group of high blood sugar hyperglycemia and produces insulin, insulin action , or both. Diabetes is caused by the inability of beta cells in the pancreas. The production of these insulin cells is little or no. This is known as type 1 mellitus diabetes (Insulin-dependent T1DM) Insulin-dependent diabetes mellitus. Objective:To evaluate the immune role of some of the immunological indicators of patients with type 1 diabetes by identifying the IL17 and IL21 concentrations, also The CD4 + and CD8 + T cells were identified by the Sandwich ELISA test. Patients and Methods: Blood samples were collected from 70 patients with type 1 diabetes (diabetes mellitus type 1) after diagnosis and 20 samples of healthy people were collected as a control group, an the study has been done during the period between October 2016 and May 2017. Results: The results  of  IL17 level showed a decrease of IL17 in patients with type 1 diabetes 114.31 ± 103.78 pg / ml compared to control group126.54±81.48pg / ml with no statistically significant difference (p> 0.05),and the results of IL21 level showed an crease of IL-21 in patients with type 1 diabetes , 209.40 ± 294.78 pg / ml compared with healthy 189.54 ± 274.82 pg / ml with no significant difference.The results showed a decrease in the concentration of CD4 + T cells in the group of patients  5.18±4.59 pg / ml compared to the healthy group whose concentration level was   5.52 ± 3.47 pg / ml.Also the results showed a high concentration of CD8+toxic T cells in the group of patients as it was 5.54 ± 7.39 pg / ml compared to the healthy group. The concentration of toxic T cells was 3.74 ± 3.57 pg / ml. There was no significant difference between the study groups for CD4 + and CD8 +. Conclusion: A number of pro-inflammatory cytokines (IL17) and inflammatory cytokines (IL21) as well as cellular immunity of CD4+ and CD8+have an important role in the development of type 1 diabetes in children and affect the immune response in the body through immunodeficiency

Study the markers of follicle stimulating hormone and transforming growth factor β1 in patients with polycystic ovarian syndrome in AL-Najaf Al-Ashraf province

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 6-15% of women in age (12-45) years . It is characterized by disturbance in menstrual cycle ,androgenic features, and presence of multiple small cyst in ovaries in ultrasound. It is the important cause of infertility. The etiology of  the disease remains unclear and may be associated with insulin resistance, obesity  , type 2  diabetes mellitus, hyperandrogenism , environmental and familial genetic factors . PCOS has a role is the appearance of  hirsutism , acne  ,  hypertension and dyslipidemia with increase risk factor of cardiovascular disease (CVD)