Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

To compare the helper function of murine T cell clones that secrete IL-2 and IFN-gamma (Th1 cells) or IL-4 and IL-5 (Th2), purified resting B cells were stimulated with F(ab')2 rabbit anti-mouse Ig (RAMG) and rabbit Ig-specific, class II MHC-restricted cloned T cells belonging to the two subsets. Both Th2 clones examined induced strong proliferative responses of B cells in the presence of RAMG, as well as the secretion of IgM and IgG1 antibodies. In contrast, the Th1 clones tested failed to stimulate B cell growth or antibody secretion. Th2-mediated B cell activation was dependent on IL-4 and IL-5, and was also inhibited by IFN-gamma or IFN-gamma produced by Th1 cells present in the same cultures. However, the failure of Th1 cells to help resting B cells could not be reversed with neutralizing anti-IFN-gamma antibody. In addition to this inhibitory effect, IFN-gamma was required for the secretion of IgG2a antibody, particularly when B cells were stimulated with polyclonal activators such as LPS. Finally, both sets of T cell clones secreted lymphokines when stimulated with purified B cells and RAMG. These experiments demonstrate that T cells that differ in lymphokine production also differ in their ability to help B cells as a result of cognate interactions at low concentrations of antigens. Moreover, IL-4, IL-5, and IFN-gamma serve different roles in the T cell-dependent proliferative and differentiative responses of resting B lymphocytes

The effect of tool fixturing quality on the design of condition monitoring systems for detecting tool conditions

Condition monitoring systems of machining processes are essential technology for improving productivity and automation. Tool wear monitoring of cutting tools is one of the important applications in this area. In this paper, the effect of collet fixturing quality on the design of condition monitoring systems to detect tool wear is discussed. The paper investigates the difference in the system's behaviour and the changes in the condition monitoring system when the cutting tool is not rigidly fastened to the collet. A group of sensors, namely acoustic emission, force, strain, vibration and sound, are used to design the condition monitoring system. Automated Sensor and Signal Processing Selection (ASPS) approach1 is implemented to address the effect of the tool holding device (collet) on the monitoring system and the most sensitive sensors and signal processing method to detect tool wear. The results prove that the change in the fixturing quality could have significant effect on the design of the condition monitoring system and the behaviour of the system

Geometrical Phase Transition on WO3_3 Surface

A topographical study on an ensemble of height profiles obtained from atomic force microscopy techniques on various independently grown samples of tungsten oxide WO$_3$ is presented by using ideas from percolation theory. We find that a continuous 'geometrical' phase transition occurs at a certain critical level-height $\delta_c$ below which an infinite island appears. By using the finite-size scaling analysis of three independent percolation observables i.e., percolation probability, percolation strength and the mean island-size, we compute some critical exponents which characterize the transition. Our results are compatible with those of long-range correlated percolation. This method can be generalized to a topographical classification of rough surface models.Comment: 3 pages, 4 figures, to appear in Applied Physics Letters (2010

Modelling of a compact anisotropic star as an anisotropic fluid sphere in f(T)f(T) gravity

In this paper, we have studied the new exact model of anisotropic star in $f(T)$ theory of gravity. The dynamical equations in $f(T)$ theory with the anisotropic fluid have been solved by using Krori-Barua solution. We have determined that all the obtained solutions are free from central singularity and potentially stable. The observed values of mass and radius of the different strange stars RX J 1856-37, Her X-1, and Vela X-12 have been used to calculate the values of unknown constants in Krori and Barua metric. The physical parameters like anisotropy, stability and redshift of the stars have been investigated in detail.Comment: Accepted in the Canadian Journal of Physic

Estimation of Export Supply Function for Citrus Fruit in Pakistan

There is strong evidence in the literature that export and economic growth have a positive relationship. In Pakistan, with an agrarian economy, earnings from primary agricultural exports are vital for the overall growth process. Fruits are the traditional export commodities, which contribute more than half of total export earnings from primary agricultural commodities. The persistent instability in world market prices for primary commodities has depressed the export earnings from these commodities over time. This poses great challenges to a country like Pakistan. The present study aims at examining changes in the volume of export of citrus fruit from Pakistan caused by such factors as changes in domestic and export prices, national product, foreign exchange rate, etc. The study uses time series data for the period 1975–2004 for citrus exports and related domestic price, export price, GDP, and foreign exchange rate, employing the co-integration and error correction techniques for analysis purposes.