Upstream Geomorphic Response to Dam Removal: The Blackfoot River, Montana

As dam removal is increasingly used as a tool to restore rivers, developing a conceptual and field-based understanding of the upstream fluvial response is critical. Using empirical data and modeling, I investigated the spatial and temporal pattern of reservoir sediment erosion and upstream channel evolution of the Blackfoot River, MT, following the 8 m base level reduction caused by the removal of Milltown Dam. Field data collected include surveys of channel bed topography and water surface elevation profiles which were integrated into a flow modeling approach. Headward erosion extended 4.5 km upstream of the dam site during the first five months following the dam removal. In the lower 1.8 km of the reservoir, up to 3 m of highly mobile silt and sand was evacuated. Upstream, the river incised into a coarse deltaic sediment deposit (D50 70mm) in the upper reservoir. The analysis of erosion through the hydrograph shows that the channel incised up to 2 m in some locations and maximum volumetric erosion of 260,000 m3 was reached several days after the flood peak (286 m3/s, 3.5 year return interval). Net erosion following the dam removal, accounting for both scour and deposition, was 150,000 m3 across the 5 km study reach. The modeling-based water surface elevation analysis revealed the intra-hydrograph pattern of erosion that otherwise would have been missed by comparing pre- and post-removal cross section topography. The post-removal evolution of the lower Blackfoot was heavily influenced by confinement of the channel and the above average discharge. Widening was associated with areas of local aggradation, whereas narrowing was associated with degradation—a finding similar to those from previous flume experiments

PlexinD1 and Semaphorin Signaling Are Required in Endothelial Cells for Cardiovascular Development

AbstractThe identification of new signaling pathways critical for cardiac morphogenesis will contribute to our understanding of congenital heart disease (CHD), which remains a leading cause of mortality in newborn children worldwide. Signals mediated by semaphorin ligands and plexin receptors contribute to the intricate patterning of axons in the central nervous system. Here, we describe a related signaling pathway involving secreted class 3 semaphorins, neuropilins, and a plexin receptor, PlexinD1, expressed by endothelial cells. Interruption of this pathway in mice results in CHD and vascular patterning defects. The type of CHD caused by inactivation of PlexinD1 has previously been attributed to abnormalities of neural crest. Here, we show that this form of CHD can be caused by cell-autonomous endothelial defects. Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis

Reinstated episodic context guides sampling-based decisions for reward.

How does experience inform decisions? In episodic sampling, decisions are guided by a few episodic memories of past choices. This process can yield choice patterns similar to model-free reinforcement learning; however, samples can vary from trial to trial, causing decisions to vary. Here we show that context retrieved during episodic sampling can cause choice behavior to deviate sharply from the predictions of reinforcement learning. Specifically, we show that, when a given memory is sampled, choices (in the present) are influenced by the properties of other decisions made in the same context as the sampled event. This effect is mediated by fMRI measures of context retrieval on each trial, suggesting a mechanism whereby cues trigger retrieval of context, which then triggers retrieval of other decisions from that context. This result establishes a new avenue by which experience can guide choice and, as such, has broad implications for the study of decisions

Adjuvant Chemotherapy Use and Health Care Costs After Introduction of Genomic Testing in Breast Cancer

Genomic testing in patients with early-stage breast cancer is associated with decreased use of chemotherapy and lower costs in younger patients, and slightly increased use of chemotherapy and higher costs in older patients. Genomic testing in actual practice may “rule out” chemotherapy in younger women, and “rule in” chemotherapy in older women