An open label hepatoprotective activity of Jawārish bisbāsā in central obesity patients

Liver plays a major role in metabolism and excretion of xenobiotics. Liver dysfunction is a major health problem that challenges health care professionals, pharmaceutical industry and drug regulatory agencies. The most common symptoms are fatigue and discomfort in abdomen while in patients who are obese with BMI > 25, about one third have metabolic syndromes. The present clinical research was conducted in Regional Research Institute of Unani Medicine, Aligarh. The patients under trial were selected from GOPD of institute for obesity and it was observed that out of total registered patients’ approx 28% have elevated liver enzymes from its normal range without any sign and symptom of hepatitis etc. Total 23 patients were selected from the study whose liver enzymes (SGOT, SGPT and ALP) were high at the baseline. Unani pharmacopoeial drug Jawārish bisbāsā 7 g daily was prescribed with lukewarm water in the morning and evening empty stomach for 8 weeks. At the end of study the result were compared with base line. It was observed that Jawārish bisbāsā significantly reduced the liver enzymes, e.g. SGOT, SGPT, Alkaline Phosphatase in comparison to baseline values. It may be concluded that Jawārish bisbāsā showed hepatoprotective effect in this clinical study.

Biallelic Variants in Seven Different Genes Associated with Clinically Suspected Bardet-Biedl Syndrome

Bardet-Biedl syndrome (BBS) is a rare clinically and genetically heterogeneous autosomal recessive multi-systemic disorder with 22 known genes. The primary clinical and diagnostic features include six different hallmarks, such as rod-cone dystrophy, learning difficulties, renal abnormalities, male hypogonadism, post-axial polydactyly, and obesity. Here, we report nine consanguineous families and a non-consanguineous family with several affected individuals presenting typical clinical features of BBS. In the present study, 10 BBS Pakistani families were subjected to whole exome sequencing (WES), which revealed novel/recurrent gene variants, including a homozygous nonsense mutation (c.94C>T; p.Gln32Ter) in the IFT27 (NM_006860.5) gene in family A, a homozygous nonsense mutation (c.160A>T; p.Lys54Ter) in the BBIP1 (NM_001195306.1) gene in family B, a homozygous nonsense variant (c.720C>A; p.Cys240Ter) in the WDPCP (NM_015910.7) in family C, a homozygous nonsense variant (c.505A>T; p.Lys169Ter) in the LZTFL1 (NM_020347.4) in family D, pathogenic homozygous 1 bp deletion (c.775delA; p.Thr259Leufs*21) in the MKKS/BBS5 (NM_170784.3) gene in family E, a pathogenic homozygous missense variant (c.1339G>A; p.Ala447Thr) in BBS1 (NM_024649.4) in families F and G, a pathogenic homozygous donor splice site variant (c.951+1G>A; p?) in BBS1 (NM_024649.4) in family H, a pathogenic bi-allelic nonsense variant in MKKS (NM_170784.3) (c.119C>G; p.Ser40*) in family I, and homozygous pathogenic frameshift variants (c.196delA; p.Arg66Glufs*12) in BBS5 (NM_152384.3) in family J. Our findings extend the mutation and phenotypic spectrum of four different types of ciliopathies causing BBS and also support the importance of these genes in the development of multi-systemic human genetic disorders

Effect of herbal <em>Unani </em>formulation on Nephrotic syndrome: A case study

807-810According to Philosophy of Unani medicine, Du’f al-Kulya is a condition in which the kidneys do not perform their normal function because of impairment in their temperament or alteration in their humoral status or anomalies in their structure. Du’f al-Kulya Barid is caused by the impairment of the temperament of kidneys specially cold impaired temperament leading to swelling, white coloured urine, decreased thirst, feeling of coldness at the site of kidney. These symptoms are very much closer to the condition of ‘Nephrotic syndrome’. That’s the real logic to use traditional herbal Unani formulation for the treatment of nephritic syndrome. The present case report is based on traditional use of herbal Unani formulation for the treatment of nephrotic syndrome. The evidence-based data is provided to support the traditional use of this valuable herbal Unani Formulation (HUF). To generate the biochemical and clinical data from a patient treated with HUF for nephrotic syndrome. A 57-year-old female from Punjabi Sikh community from capital Delhi was diagnosed nephrotic syndrome and treated for four months with a combination of Unani herbal drugs. The patient was advised to take 10 g of powder of HUF twice with Arq Mako and Arq Kasni 20 mL each diluted with equal amount of plain water in the morning and evening. The treatment was continued for four months and investigations for renal functions were carried out and patient was clinically examined at each visit. Laboratory reports and clinical sign and symptoms revealed that HUF reduces serum creatinine, urea and swelling on face and body. Increased blood pressure was declined compared to base line reading. In the present case study, the HUF has shown promising nephroprotective activity by significantly reducing serum creatinine, urea and protein leakage in urine

PHYTOPHARMACOLOGY OF AN IMPORTANT UNANI DRUG BAZR-UL-BANJ (HYOSCYAMUS NIGER LINN.) – REVIEW

Objective: Bazr-ul-Banj syn. Ajwain khurasani (Hyoscyamus niger Linn.) is one of the important drug mentioned in Unani literature. It mentioned by the great Unani philosopher Dioscorides (first century AD) in his treatise Kitab-al-Hashaish. According to Unani philosophy, Bazr-ul-Banj is in third-degree category according to its temperamental nature. H. niger Linn. contains tropane alkaloids in good quantity, mainly hyoscyamine and scopolamine. Methods: Unani classical literature was searched from recent to past available in different libraries. For phytochemistry, pharmacology, and clinical studies to prove, the importance computerized databases such as Medline, PubMed, Ovid SP, Google Scholar, and Science-direct were searched. All the information of plant available in Urdu, Persian, Arabic, and studies published abstract were included in the study. Results: Fourteen Unani books were referred and 18 pharmacological studies were recognized. The action of Bazr-ul-Banj mentioned in Unani classical literature are Hazim (Digestive), Mudammil (Cicatrizant), Mujaffif (Dessicant), Mukhaddir (Anesthetic), Munashshi (Narcotic), Munawwim (Hypnotic), Musakkin (Sedative), Musakkin-e-Alam (Analgesic), Raade (divertive), Qabiz (Astringent), etc., and useful in Amraz-e-asbania (nervous affections), Amraz-e-Raham (uterine spasm and pain), Dard wa Alam (pain), Ikhtelaj-e-Qalb (palpitation), Junoon (mania), Niqras (Gout), Zeequn Nafas (Bronchial asthma), etc. H. niger Linn. showed many pharmacological effects included antimicrobial, anticancer, analgesic, anti-inflammatory, antipyretic, antihypertensive, and antidiarrheal activities in different clinical and experimental studies. Conclusion: This presentation is an attempt to showcase the action, uses mentioned in Unani literature, chemical constituent, and pharmacological and toxicological effects at one place. It may also observe that the drug is having many actions which may be beneficial in cases of COVID-19. It may be concluded this should be tested as adjuvant medicine in cases of COVID-19

Zahar Mohra (Bezoar) an Alexipharmic Unani Mineral Drug: Review

Rhazes (855-925 AD) the great scholar of Unani System Medicine (USM), initially classified Materia Medica according to animal, mineral and plant origin. Zahar Mohra is a Greenish white, good‑looking&nbsp;mineral stone with a slippery feel having a good smell and taste obtained from mines. In USM it is considered to be a universal antidote. The great Unani Scholar Yuhannā Māsawayh (777-857 AD), was one of the first physicians who mentioned the medicinal uses of Zahar Mohra.&nbsp;In Unani Medicine it is used to treat epidemic diseases such as Haiza (Cholera), Tawoon (Plague), as an antidote for different poisoning and to provide strength to vital organs. To check adulteration the quality standard of Zahar Mohra has been laid down. All the available information regarding this historically important stone has been compiled which will help the researcher to find a solution of pandemic disease in the current scenario. Key words:&nbsp;Zahar Mohra, Unani Medicine, Fade Zahar Kani, Mineral Bezoa

Nephroprotective Effect of Asgand Powder (Withania somnifera Dunal) on Cisplatin Induced Renal Injury in Rats

Background: The nephroprotective effect of crude powder of Asgand (Withania samnifera Dunal) was studied against cisplatin induced renal toxicity in wistar albino rats of either sex. Results: The powder of Withania somnifera Dunal at dose level 700 and 1400 mg/kg body wt/day showed reduction in elevated blood urea, serum creatinine and uric acid. It was found to protect kidney damage by cisplatin induced nephrotoxicity as evidenced by oral administration of Asgand (Withania samnifera Dunal) (700 mg/kg) inhibited the rise in blood urea nitrogen (121.7%), Serum cratinine (76.64%), and uric acid (92.7%). There were 92.71% inhibition in the rise of BUN, 92% inhibition in the rise of serum creatinine and 106.6% inhibition in the rise of uric acid with 1400 mg. Conclusion: The findings suggest that the famous Unani herb Asgand Powder possesses marked nephroprotective activity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin. Keywords: Withania somnifera Dunal, Cisplatin, Asgand, Nephroprotection, Unani Medicin

An open label hepatoprotective activity of Jawārish bisbāsā in central obesity patients

57-62Liver plays a major role in metabolism and excretion of xenobiotics. Liver dysfunction is a major health problem that challenges health care professionals, pharmaceutical industry and drug regulatory agencies. The most common symptoms are fatigue and discomfort in abdomen while in patients who are obese with BMI > 25, about one third have metabolic syndromes. The present clinical research was conducted in Regional Research Institute of Unani Medicine, Aligarh. The patients under trial were selected from GOPD of institute for obesity and it was observed that out of total registered patients’ approx 28% have elevated liver enzymes from its normal range without any sign and symptom of hepatitis etc. Total 23 patients were selected from the study whose liver enzymes (SGOT, SGPT and ALP) were high at the baseline. Unani pharmacopoeial drug Jawārish bisbāsā 7 g daily was prescribed with lukewarm water in the morning and evening empty stomach for 8 weeks. At the end of study the result were compared with base line. It was observed that Jawārish bisbāsā significantly reduced the liver enzymes, e.g. SGOT, SGPT, Alkaline Phosphatase in comparison to baseline values. It may be concluded that Jawārish bisbāsā showed hepatoprotective effect in this clinical study

Comparative toxicity study on classical and modified version of Jawarish Jalinoos (a traditional Unani formulation) in rats

Background: Jawarish Jalinoos (JJ) is a classical semisolid traditional Unani formulation clinically used for the treatment of weakness of vital organs, liver, and stomach. Although JJ has been widely used clinically for several decades, no scientific report is available for its safety. Methods: JJ and its sugar-free tablet version (SFJJ; formulated to target diabetic population) were assessed for safety in rats. Ninety-day repeated dose oral toxicity study was performed as per the Organisation for Economic Co-operation and Development Guideline 408. JJ was orally administered at the dose of 2000 mg/kg bw/d, whereas SFJJ was orally administered at the doses of 506 mg/kg body weight (bw)/d, 1012 mg/kg bw/d, and 2024 mg/kg bw/d for 90 days. The animals were periodically observed for clinical signs of toxicity, mortality, morbidity, body weight changes, and feed consumption. At the end of the study, hematology, clinical biochemistry, electrolytes, gross pathology, relative organ weight, and histological examination were performed. Results: Treatment with SFJJ and JJ showed no significant differences in body weight gain, feed consumption, hematology, clinical biochemistry, and serum electrolytes. No gross pathological findings and differences in relative organ weights were observed between control and drug treated rats. Histological examination revealed no toxicologically significant abnormalities related with SFJJ or JJ treatment. Conclusion: The 90-day repeated dose oral toxicity study demonstrates that the no observed adverse effect level of SFJJ and JJ is greater than 2024 mg/kg bw/d and 2000 mg/kg bw/d (p.o.) in rats, respectively. Both formulations were found to be safe up to the tested dose levels and experimental conditions, and therefore safe for clinical use as specified in the literature

Jurnal al-hikmah : international journal for religious studies

Jurnal Ilmiah Al-Hikmah yang diterbitkan oleh Pusat Pengkajian Islam dan Masyarakat (PPIM) IAIN alauddin Makassar, menerima sumbangan naskah tulisan nberupa artikel hasil telaah dan hasil penelitian dalam bidang keagamaan dan penerbit lainnya.263 hlm. ilus; 23c