3,188 research outputs found
The use of MHC class I or class II 'knock out' mice to investigate the role of these antigens in allosensitization
Flavonoid intake and the risk of age-related cataract in China’s Heilongjiang Province
Background/Objectives: Epidemiological evidence suggests that diets rich in flavonoids may reduce the risk of developing age-related cataract (ARC). Flavonoids are widely distributed in foods of plant origin and the objective of this study was to evaluate retrospectively the association between the intakes of the five flavonoid subclasses and the risk of ARC. Â Subjects/Methods: A population-based case-control study (249 cases and 66 controls) was carried out in Heilongjiang province, which is located in the Northeast of China, and where intakes and availability of fresh vegetables and fruits can be limited. Dietary data gathered by food-frequency questionnaire (FFQ) were used to calculate flavonoid intake. Adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated by logistic regression. Â Results: No linear associations between risk of developing ARC and intakes of total dietary flavonoids, anthocyanidins, flavon-3-ol, flavanone, total flavones or total flavonols were found, but quercetin and isorhamnetin intake was inversely associated with ARC risk (OR 11.78, 95% CI: 1.62-85.84, P<0.05, and OR 6.99, 95% CI:1.12-43.44, P<0.05, quartile 4 vs quartile 1, respectively). Â Conclusion: As quercetin is contained in many plant foods and isorhamnetin is only contained in very few foods, we concluded that higher quercetin intake may be an important dietary factor in the reduction of risk of age-related cataract
Diffuse Gamma Rays: Galactic and Extragalactic Diffuse Emission
"Diffuse" gamma rays consist of several components: truly diffuse emission
from the interstellar medium, the extragalactic background, whose origin is not
firmly established yet, and the contribution from unresolved and faint Galactic
point sources. One approach to unravel these components is to study the diffuse
emission from the interstellar medium, which traces the interactions of high
energy particles with interstellar gas and radiation fields. Because of its
origin such emission is potentially able to reveal much about the sources and
propagation of cosmic rays. The extragalactic background, if reliably
determined, can be used in cosmological and blazar studies. Studying the
derived "average" spectrum of faint Galactic sources may be able to give a clue
to the nature of the emitting objects.Comment: 32 pages, 28 figures, kapproc.cls. Chapter to the book "Cosmic
Gamma-Ray Sources," to be published by Kluwer ASSL Series, Edited by K. S.
Cheng and G. E. Romero. More details can be found at
http://www.gamma.mpe-garching.mpg.de/~aws/aws.htm
Body size and the risk of biliary tract cancer: a population-based study in China
Though obesity is an established risk factor for gall bladder cancer, its role in cancers of the extrahepatic bile ducts and ampulla of Vater is less clear, as also is the role of abdominal obesity. In a population-based case–control study of biliary tract cancer in Shanghai, China, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for biliary tract cancer in relation to anthropometric measures, including body mass index (BMI) at various ages and waist-to-hip ratio (WHR), adjusting for age, sex, and education. The study included 627 patients with biliary tract cancer (368 gall bladder, 191 bile duct, 68 ampulla of Vater) and 959 healthy subjects randomly selected from the population. A higher BMI at all ages, including early adulthood (ages 20–29 years), and a greater WHR were associated with an increased risk of gall bladder cancer. A high usual adult BMI (⩾25) was associated with a 1.6-fold risk of gall bladder cancer (95% CI 1.2–2.1, P for trend <0.001). Among subjects without gallstones, BMI was also positively associated with gall bladder cancer risk. Regardless of BMI levels, increasing WHR was associated with an excess risk of gall bladder cancer risk, with those having a high BMI (⩾25) and a high WHR (>0.90) having the highest risk of gall bladder cancer (OR=12.6, 95% CI 4.8–33.2), relative to those with a low BMI and WHR. We found no clear risk patterns for cancers of the bile duct and ampulla of Vater. These results suggest that both overall and abdominal obesity, including obesity in early adulthood, are associated with an increased risk of gall bladder cancer. The increasing prevalence of obesity and cholesterol stones in Shanghai seems at least partly responsible for the rising incidence of gall bladder cancer in Shanghai
Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China
Previous studies have shown a positive association between chronic typhoid carriage and biliary cancers. We compared serum Salmonella enterica serovar Typhi antibody titers between biliary tract cancer cases, biliary stone cases without evidence of cancer, and healthy subjects in a large population-based case-control study in Shanghai, China
The All-Data-Based Evolutionary Hypothesis of Ciliated Protists with a Revised Classification of the Phylum Ciliophora (Eukaryota, Alveolata)
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The file attached is the published version of the article
Coefficient, Distortion and Growth Inequalities for Certain Close-to-Convex Functions
In the present investigation, certain subclasses of close-to-convex functions
are investigated. In particular, we obtain an estimate for the Fekete-Szeg\"o
functional for functions belonging to the class, distortion, growth estimates
and covering theorems
Death of a tumor: targeting CCN in pancreatic cancer
The matricellular protein CCN2 (connective tissue growth factor, CTGF) has been previously implicated in tumorigenesis. In pancreatic cancer cells, CCN2 expression occurs downstream of ras/MEK/ERK. Direct evidence that CCN2 mediates tumor progression in pancreatic cancer has been lacking. An exciting recent report by Bennewith et al. (Cancer Res 69:775–784, 2009) has used shRNA knockdown of CCN2 to illustrate that CCN2 contributes to growth of pancreatic tumor cells, both in vitro and in vivo. This report briefly summarizes these findings
Decaying Dark Matter in Supersymmetric Model and Cosmic-Ray Observations
We study cosmic-rays in decaying dark matter scenario, assuming that the dark
matter is the lightest superparticle and it decays through a R-parity violating
operator. We calculate the fluxes of cosmic-rays from the decay of the dark
matter and those from the standard astrophysical phenomena in the same
propagation model using the GALPROP package. We reevaluate the preferred
parameters characterizing standard astrophysical cosmic-ray sources with taking
account of the effects of dark matter decay. We show that, if energetic leptons
are produced by the decay of the dark matter, the fluxes of cosmic-ray positron
and electron can be in good agreements with both PAMELA and Fermi-LAT data in
wide parameter region. It is also discussed that, in the case where sizable
number of hadrons are also produced by the decay of the dark matter, the mass
of the dark matter is constrained to be less than 200-300 GeV in order to avoid
the overproduction of anti-proton. We also show that the cosmic gamma-ray flux
can be consistent with the results of Fermi-LAT observation if the mass of the
dark matter is smaller than nearly 4 TeV.Comment: 24 pages, 5 figure
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