Modeling Aquifer Storage and Recovery of Treated Drinking Water

Aquifer storage and recovery (ASR) is a practice in which treated drinking water is stored in an aquifer during periods of excess supply and withdrawn and used, with only disinfection, during periods of peak demand. The primary advantages of the method is a reduced size of treatment and constructed storage facilities. However, the propriety of the method depends upon the efficiency of the recovery process and the extent of water quality changes that occur during subsurface storage. Due to existing and evolving water quality regulations, trihalomethane and haloacetic acid concentrations are parameters of concern. These parameters, and other species concentrations, are affected by hydrodynamic, physical, chemical, and biological processes that are operative in the subsurface environment. Relevant processes were identified, represented in mathematical form, and approximated in a numerical model using the finite element method. The resultant model was validated by comparison to analytical solutions, and literature results for a case of density-dependent flow. The model was then used to simulate ASR operations at two sites: Kerrville, Texas, and Marathon, Florida. Model calibration for a conservative species was used to estimate hydrodynamic dispersion, while model predictions were made for other species and for subsequent cycles of ASR. Good agreement was achieved between the model and field data for a conservative species, while reactive processes were evident for trihalomethane species. The rate of apparent trihalomethane species degradation was directly related to the degree of bromination, which is consistent with expectations based upon previous research.Master of Science in Environmental Engineerin

Evaluation of changes in perfusion defect and left ventricular systolic function using Tc-99m Tetrofosmin single photon emission computed tomography over 3 month period in patients of Acute Myocardial Infarction undergoing primary angioplasty

Background After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the procedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3–4 month period. Hence, we undertook this study on the natural course of recovery/changes occurring in perfusion defect size and LV function in first 3 months after primary angioplasty Material and methods 30 consecutive cases of first AMI who were taken up for Primary angioplasty were enrolled into the study. Resting MPI(Myocardial perfusion imaging) was done within 24–72 hrs of admission using Tc-99m–Tetrofosmin and after 10–14 weeks. Analysis of LVEF (left ventricular ejection fraction), summed segmental score and extent of perfusion defect was done. Images were processed using autocardiac software of emory tool box and quantification was done using QPS (quantitative perfusion SPECT) and QGS (qualitative perfusion SPECT) softwares. 20 segment scoring method was used for quantification on bull’s eye images. Student t test (two tailed, dependent) was used to find the significance of study parameters on continuous scale within each group. Effect size was computed to find the effect. Pearson correlation between perfusion defect and LVEF was performed at acute stage and after 10–14 weeks. Results The average acute perfusion defect extent was 19.76 ± 12.89% which after 3months became 16.79 ± 12.61%. The summed segmental score changed from 14.31 ± 10.58 to 11.38 ± 10.03 and LVEF improved from 48.40 ± 13.15% to 53.37 ± 12.8%. There was significant improvement in LVEF from acute setting to 10–14 weeks (p = 0.001). There was significant lowering of summed score (p = 0.007). Perfusion defect size showed significant reduction (p = 0.030). Three patients showed deterioration in perfusion defect size and in summed score with reduction in LVEF. Four patients had no change in any of the parameters. Correlation between perfusion defect and LVEF was strong both at baseline (r = -0.705, p &lt; 0.001) and after 10-18 weeks (r = -0.766, p &lt; 0.001). Conclusion The changes we found in 3 months are similar to earlier studies and also to studies using follow up at 6 months to 1 year. We feel that 3 months is a good enough time to accurately assess the success of primary angioplasty.BACKGROUND. After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the pro­cedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3–4 month period. Hence, we undertook this study on the natural course of recovery/changes occurring in perfusion defect size and LV function in first 3 months after primary angioplasty. MATERIAL AND METHODS. 30 consecutive cases of first AMI who were taken up for Primary angioplasty were enrolled into the study. Resting MPI (Myocardial perfusion imaging) was done within 24–72 hrs of admission using Tc-99m–Tetrofosmin and after 10–14 weeks. Analysis of LVEF (left ventricular ejection fraction), summed segmental score and extent of perfusion defect was done. Images were processed using autocardiac software of emory tool box and quantification was done using QPS (quantitative perfusion SPECT) and QGS (qualitative perfusion SPECT) softwares. 20 segment scoring method was used for quantification on bull’s eye images. Student t test (two tailed, dependent) was used to find the significance of study parameters on continuous scale within each group. Effect size was computed to find the effect. Pearson correlation between perfusion defect and LVEF was performed at acute stage and after 10–14 weeks. RESULTS. The average acute perfusion defect extent was 19.76 ± 12.89% which after 3 months became 16.79 ± 12.61%. The summed segmental score changed from 14.31 ± 10.58 to 11.38 ± 10.03 and LVEF improved from 48.40 ± 13.15% to 53.37 ± 12.8%. There was significant improvement in LVEF from acute setting to 10–14 weeks (p = 0.001). There was significant lowering of summed score (p = 0.007). Perfusion defect size showed significant reduction (p = 0.030). Three patients showed deterioration in perfusion defect size and in summed score with reduction in LVEF. Four patients had no change in any of the parameters. Correlation between perfusion defect and LVEF was strong both at baseline (r = -0.705, p < 0.001) and after 10–18 weeks (r = -0.766, p < 0.001). CONCLUSION. The changes we found in 3 months are similar to earlier studies and also to studies using follow up at 6 months to 1 year. We feel that 3 months is a good enough time to accurately assess the success of primary angioplasty.

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in mycobacterium tuberculosis–infected individuals

Copyright © 2009 by the American Thoracic Society.Rationale: An effective new tuberculosis (TB) vaccine regimen must be safe in individuals with latent TB infection (LTBI) and is a priority for global health care. Objectives: To evaluate the safety and immunogenicity of a leading new TB vaccine, recombinant Modified Vaccinia Ankara expressing Antigen 85A (MVA85A) in individuals with LTBI. Methods: An open-label, phase I trial of MVA85A was performed in 12 subjects with LTBI recruited from TB contact clinics in Oxford and London or by poster advertisements in Oxford hospitals. Patients were assessed clinically and had blood samples drawn for immunological analysis over a 52-week period after vaccination with MVA85A. Thoracic computed tomography scans were performed at baseline and at 10 weeks after vaccination. Safety of MVA85A was assessed by clinical, radiological, and inflammatory markers. The immunogenicity of MVA85A was assessed by IFNγ and IL-2 ELISpot assays and FACS. Measurements and Main Results: MVA85A was safe in subjects with LTBI, with comparable adverse events to previous trials of MVA85A. There were no clinically significant changes in inflammatory markers or thoracic computed tomography scans after vaccination. MVA85A induced a strong antigen-specific IFN-γ and IL-2 response that was durable for 52 weeks. The magnitude of IFN-γ response was comparable to previous trials of MVA85A in bacillus Calmette-Guérin–vaccinated individuals. Antigen 85A–specific polyfunctional CD4+ T cells were detectable prior to vaccination with statistically significant increases in cell numbers after vaccination. Conclusions: MVA85A is safe and highly immunogenic in individuals with LTBI. These results will facilitate further trials in TB-endemic areas.Oxford Biomedical Research Centre, Wellcome Trust, and AFTBVAC

Anatomical and histochemical analysis of vegetative organs of Vernonia ferruginea Less. (Asteraceae)

Vernonia ferruginea Less. is a perennial shrub species, present in several regions of Brazil, especially in the savanna. It is popularly used as a phytotherapic. This fact justifies the need to anatomically characterize the plant for its accurate identification and to conduct histochemical studies with the aim of identifying the chemical nature of its cellular constituents. The species-specific data will contribute significantly to pharmaceutical quality control and also provide information about the sites of specific chemical compounds. Samples of V. ferruginea vegetative organs were collected and submitted to the usual plant anatomy and histochemical techniques. The leaves are anfihipoestomática with anomocytic stomata; have tector and glandular trichomes that store essential oils. The stem has collateral-type vascular bundles arranged in a eustele structure; it also has glandular and tector trichomes. The root has brachysclereids, endoderm with various chemical compounds and vascular bundles having axial elements and rays. Few differences were found in the structure of vegetative organs in relation to other species of the genus, confirming the importance of the details shown.Key words: Plant anatomy, assapeixe-branco, essential oils

A New Data Integrity Checking Algorithm For Data Transmission In Wireless Sensor Networks

We based on the possibility of potential in material science, we design IDDR, a multi-way powerful steering calculation, to determine this contention. By developing a virtual half and half potential field, IDDR isolates parcels of utilizations with various QoS necessities as per the weight appointed to every bundle, and courses them towards the sink through various ways to enhance the information constancy for respectability delicate applications and lessen the conclusion to-end defer for delay-touchy ones. Utilizing the Lyapunov float method, we demonstrate that IDDR is steady. Results exhibit that IDDR gives information uprightness and postpone separated administrations

Multiscale Spatiotemporal Analysis of Extreme Events in the Gomati River Basin, India

Accelerating climate change is causing considerable changes in extreme events, leading to immense socioeconomic loss of life and property. In this study, we investigate the characteristics of extreme climate events at a regional scale to ‐understand these events’ propagation in the near fu-ture. We have considered sixteen extreme climate indices defined by the World Meteorological Or-ganization’s Expert Team on Climate Change Detection and Indices from a long‐term dataset (1951– 2018) of 53 locations in Gomati River Basin, North India. We computed the present and future spatial variation of theses indices using the Sen’s slope estimator and Hurst exponent analysis. The periodicities and non‐stationary features were estimated using the continuous wavelet transform. Bivariate copulas were fitted to estimate the joint probabilities and return periods for certain com-binations of indices. The study results show different variation in the patterns of the extreme climate indices: D95P, R95TOT, RX5D, and RX showed negative trends for all stations over the basin. The number of dry days (DD) showed positive trends over the basin at 36 stations out of those 17 stations are statistically significant. A sustainable decreasing trend is observed for D95P at all stations, indi-cating a reduction in precipitation in the future. DD exhibits a sustainable decreasing trend at almost all the stations over the basin barring a few exceptions highlight that the basin is turning drier. The wavelet power spectrum for D95P showed significant power distributed across the 2–16‐year bands, and the two‐year period was dominant in the global power spectrum around 1970–1990. One interest-ing finding is that a dominant two‐year period in D95P has changed to the four years after 1984 and remains in the past two decades. The joint return period’s resulting values are more significant than values resulting from univariate analysis (R95TOT with 44% and RTWD of 1450 mm). The difference in values highlights that ignoring the mutual dependence can lead to an underestimation of extremes. © 2021 by the author. Licensee MDPI, Basel, Switzerland

Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?

Since 2000, under the Fifth and subsequent Framework Programmes, the European Commission has funded research to spur the development of a malaria vaccine. This funding has contributed to the promotion of an integrated infrastructure consisting of European basic, applied and clinical scientists in academia and small and medium enterprises, together with partners in Africa. Research has added basic understanding of what is required of a malaria vaccine, allowing selected candidates to be prioritized and some to be moved forward into clinical trials. To end the health burden of malaria, and its economic and social impact on development, the international community has now essentially committed itself to the eventual eradication of malaria. Given the current tentative advances towards elimination or eradication of malaria in many endemic areas, malaria vaccines constitute an additional and almost certainly essential component of any strategic plan to interrupt transmission of malaria. However, funding for malaria vaccines has been substantially reduced in the Seventh Framework Programme compared with earlier Framework Programmes, and without further support the gains made by earlier European investment will be lost

A novel PAX5 rearrangement in TCF3-PBX1 acute lymphoblastic leukemia: a case report.

BACKGROUND: Chromosome translocations are a hallmark of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Additional genomic aberrations are also crucial in both BCP-ALL leukemogenesis and treatment management. Herein, we report the phenotypic and molecular cytogenetic characterization of an extremely rare case of BCP-ALL harboring two concomitant leukemia-associated chromosome translocations: t(1;19)(q23;q13.3) and t(9;17)(p13;q11.2). Of note, we described a new rearrangement between exon 6 of PAX5 and a 17q11.2 region, where intron 3 of SPECC1 is located. This rearrangement seems to disrupt PAX5 similarly to a PAX5 deletion. Furthermore, a distinct karyotype between diagnosis and relapse samples was observed, disclosing a complex clonal evolution during leukemia progression. CASE PRESENTATION: A 16-year-old boy was admitted febrile with abdominal and joint pain. At clinical investigation, he presented with anemia, splenomegaly, low white blood cell count and 92% lymphoblast. He was diagnosed with pre-B ALL and treated according to high risk GBTLI-ALL2009. Twelve months after complete remission, he developed a relapse in consequence of a high central nervous system and bone marrow infiltration, and unfortunately died. CONCLUSIONS: To our knowledge, this is the first report of a rearrangement between PAX5 and SPECC1. The presence of TCF3-PBX1 and PAX5-rearrangement at diagnosis and relapse indicates that both might have participated in the malignant transformation disease maintenance and dismal outcome

Salinity Measurements Collected by Fishermen Reveal a “River in the Sea” Flowing Along the Eastern Coast of India

Being the only tropical ocean bounded by a continent to the north, the Indian Ocean is home to the most powerful monsoon system on Earth. Monsoonal rains and winds induce huge river discharges and strong coastal currents in the northern Bay of Bengal. To date, the paucity of salinity data has prevented a thorough description of the spreading of this freshwater into the bay. The potential impact of the salinity on cyclones and regional climate in the Bay of Bengal is, however, a strong incentive for a better description of the water cycle in this region. Since May 2005, the National Institute of Oceanography conducts a program in which fishermen collect seawater samples in knee-deep water at eight stations along the Indian coastline every 5 days. Comparison with open-ocean samples shows that this cost-effective sampling strategy is representative of offshore salinity evolution. This new dataset reveals a salinity drop exceeding 10 g kg−1 in the northern part of the bay at the end of the summer monsoon. This freshening signal propagates southward in a narrow (~100 km wide) strip along the eastern coast of India, and reaches its southern tip after 2.5 months. Satellite-derived alongshore-current data shows that the southward propagation of this “river in the sea” is consistent with transport by seasonal coastal currents, while other processes are responsible for the ensuing erosion of this coastal freshening. This simple procedure of coastal seawater samples collection could further be used to monitor phytoplankton concentration, bacterial content, and isotopic composition of seawater along the Indian coastlin