12 research outputs found
Androgen-independent prostate carcinoma and androgen-receptor: recent progress in molecular genetics
Potential action of IGF-I and EGF on androgen receptor nuclear transfer and transactivation in normal and cancer human prostate cell lines
A stable prostatic bioluminescent cell line to investigate androgen and antiandrogen effects.
Prise en charge du cancer du pĂ©nis en 2010 : rapport du forum du ComitĂ© de cancĂ©rologie de lâAssociation française dâurologie â organes gĂ©nitaux externes (CCAFU-OGE)
1013 INTEREST OF EARLY CONFIRMATORY BIOPSIES AND CENTRALIZED PATHOLOGICAL REVIEW TO SELECT PROSTATE CANCER PATIENTS FOR ACTIVE SURVEILLANCE
Intermittent Androgen Castration: A Biological Reality during Intermittent Treatment in Metastatic Prostate Cancer?
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population
Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially influence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confidence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG < 21 vs. CAG > 21 and CAG < 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians