Management of Digital Libraries for Active Learning Environment: Trends and Challenges

E-content learning is one of the innovative information system based learning environment that has adopted in every library throughout the world. It deals with work-related the digital library even in the presence of an electronic resources department. It can be achieved with the assistance of digital technologies for making to access and delivering the contents. A virtual classroom for learning and training has a sustainable increase in recent days. User-friendly Libraries is the major source of that contributes to improving the knowledge of both faculties and students through active search. The biggest advantage of E-content learning is you can learn at any convenient time at your workplace. Modern Libraries that have the facility of a fully automated system that helps to search the book, issue, and renewal and receiving of books. They are several formats of e-books, journals and articles are available on the internet. From reading a daily newspaper, textbooks, magazines and periodical journals are available in just the web browser. To evaluate the performance of the impact of research and books by Bibliometrics and measures the impact of characteristics of science and scientific research by Scientometrics are used. Networking technologies like internet and intranet are used for sharing the e-content in a smart manner. Every day the volume of data has increased rapidly, with the help of Digital Technologies like Cloud Computing and Big Data are used for storing and retrieving a large volume of data. In this paper mainly focuses on the current trends and challenges like unauthorized access and plagiarism that are faced by e-content management. And also give suggestion to overcome these challenges in digital libraries management are discussed

In silico and in vitro analysis of quorum quenching active phytochemicals from the ethanolic extract of medicinal plants against quorum sensing mediated virulence factors of Acinetobacter baumannii

Inhibition of quorum sensing called quorum quenching (QQ) is now extensively utilized in the prevention of bacterial infections. In the present study, in silico and in vitro analysis of quorum quenching (QQ) or anti-Quorum sensing (QS) activity of ethanolic extract of medicinal plants against QS mediated virulence factors of human pathogenic bacteria Acinetobacter baumannii has been investigated. The effect of plant extracts on QS by acyl homoserine lactone (AHL) has been carried out by quantification of secreted AHL by high-pressure liquid chromatography (HPLC). Measurement of QQ activity was determined by maximum inhibition of virulence factors and AHL production which was recorded in E. globules and A. indica extracts. In silico analysis was studied with possible bioactive compounds in the ethanolic extract of respective plant material that were characterized by gas chromatography equipped with mass spectroscopy (GCMS) against the enzyme responsible for the production of signaling molecule which mediates QS AHL synthase. Distinct reduction of all the QS-mediated virulence factors was recorded in the E. globules and A. indica. Among the different bioactive compounds, the ethanolic leaf extract of E. globules of GCMS analyzed compound, Hexadeconoic acid, 1-(hydroxymethyl), 1, 2-ethannediyl ester interacted with 1KZF protein (AHL synthase) and showed binding energy of −11.2 kcal/mol to MET 42 and TYR 54. Phytochemicals mediated inhibition of AHL synthase activity which was responsible for AHL production would suggest the possible utilization of plant extracts as an antibacterial agent to fight against disease-causing pathogenic bacteria