2,874 research outputs found
Six-Loop Anomalous Dimension of Twist-Three Operators in N=4 SYM
The result for the six-loop anomalous dimension of twist-three operators in
the planar N=4 SYM theory is presented. The calculations were performed along
the paper arXiv:0912.1624. This result provides a new data for testing the
proposed spectral equations for planar AdS/CFT correspondence.Comment: 19 pages, typos corrected, details adde
Five-loop anomalous dimension at critical wrapping order in N=4 SYM
We compute the anomalous dimension of a length-five operator at five-loop
order in the SU(2) sector of N=4 SYM theory in the planar limit. This is
critical wrapping order at five loops. The result is obtained perturbatively by
means of N=1 superspace techniques. Our result from perturbation theory
confirms explicitly the formula conjectured in arXiv:0901.4864 for the
five-loop anomalous dimension of twist-three operators. We also explicitly
obtain the same result by employing the recently proposed Y-system.Comment: LaTeX, feynmp, 34 pages, 21 figures, 8 table
Adjusting for multiple prognostic factors in the analysis of randomised trials
Background: When multiple prognostic factors are adjusted for in the analysis of a randomised trial, it is unclear (1) whether it is necessary to account for each of the strata, formed by all combinations of the prognostic factors (stratified analysis), when randomisation has been balanced within each stratum (stratified randomisation), or whether adjusting for the main effects alone will suffice, and (2) the best method of adjustment in terms of type I error rate and power, irrespective of the randomisation method.
Methods: We used simulation to (1) determine if a stratified analysis is necessary after stratified randomisation, and (2) to compare different methods of adjustment in terms of power and type I error rate. We considered the following methods of analysis: adjusting for covariates in a regression model, adjusting for each stratum using either fixed or random effects, and Mantel-Haenszel or a stratified Cox model depending on outcome.
Results: Stratified analysis is required after stratified randomisation to maintain correct type I error rates when (a) there are strong interactions between prognostic factors, and (b) there are approximately equal number of patients in each stratum. However, simulations based on real trial data found that type I error rates were unaffected by the method of analysis (stratified vs unstratified), indicating these conditions were not met in real datasets. Comparison of different analysis methods found that with small sample sizes and a binary or time-to-event outcome, most analysis methods lead to either inflated type I error rates or a reduction in power; the lone exception was a stratified analysis using random effects for strata, which gave nominal type I error rates and adequate power.
Conclusions: It is unlikely that a stratified analysis is necessary after stratified randomisation except in extreme
scenarios. Therefore, the method of analysis (accounting for the strata, or adjusting only for the covariates) will not generally need to depend on the method of randomisation used. Most methods of analysis work well with large
sample sizes, however treating strata as random effects should be the analysis method of choice with binary or
time-to-event outcomes and a small sample size
The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies
Adjustment for prognostic covariates can lead to increased power in the analysis of randomized trials. However, adjusted analyses are not often performed in practice
Double-logs, Gribov-Lipatov reciprocity and wrapping
We study analytical properties of the five-loop anomalous dimension of
twist-2 operators at negative even values of Lorentz spin. Following L. N.
Lipatov and A. I. Onishchenko, we have found two possible generalizations of
double-logarithmic equation, which allow to predict a lot of poles of anomalous
dimension of twist-2 operators at all orders of perturbative theory from the
known results. Second generalization is related with the reciprocity-respecting
function, which is a single-logarithmic function in this case. We have found,
that the knowledge of first orders of the reciprocity-respecting function gives
all-loop predictions for the highest poles. Obtained predictions can be used
for the reconstruction of a general form of the wrapping corrections for
twist-2 operators.Comment: 17 pages, references adde
Reporting on covariate adjustment in randomised controlled trials before and after revision of the 2001 CONSORT statement: a literature review
<p>Abstract</p> <p>Objectives</p> <p>To evaluate the use and reporting of adjusted analysis in randomised controlled trials (RCTs) and compare the quality of reporting before and after the revision of the CONSORT Statement in 2001.</p> <p>Design</p> <p>Comparison of two cross sectional samples of published articles.</p> <p>Data Sources</p> <p>Journal articles indexed on PubMed in December 2000 and December 2006.</p> <p>Study Selection</p> <p>Parallel group RCTs with a full publication carried out in humans and published in English</p> <p>Main outcome measures</p> <p>Proportion of articles reported adjusted analysis; use of adjusted analysis; the reason for adjustment; the method of adjustment and the reporting of adjusted analysis results in the main text and abstract.</p> <p>Results</p> <p>In both cohorts, 25% of studies reported adjusted analysis (84/355 in 2000 vs 113/422 in 2006). Compared with articles reporting only unadjusted analyses, articles that reported adjusted analyses were more likely to specify primary outcomes, involve multiple centers, perform stratified randomization, be published in general medical journals, and recruit larger sample sizes. In both years a minority of articles explained why and how covariates were selected for adjustment (20% to 30%). Almost all articles specified the statistical methods used for adjustment (99% in 2000 vs 100% in 2006) but only 5% and 10%, respectively, reported both adjusted and unadjusted results as recommended in the CONSORT guidelines.</p> <p>Conclusion</p> <p>There was no evidence of change in the reporting of adjusted analysis results five years after the revision of the CONSORT Statement and only a few articles adhered fully to the CONSORT recommendations.</p
Generalized scaling function from light-cone gauge AdS_5 x S^5 superstring
We revisit the computation of the 2-loop correction to the energy of a folded
spinning string in AdS_5 with an angular momentum J in S^5 in the scaling limit
log S, J >>1 with J / log S fixed. This correction gives the third term in the
strong-coupling expansion of the generalized scaling function. The computation,
using the AdS light-cone gauge approach developed in our previous paper, is
done by expanding the AdS_5 x S^5 superstring partition function near the
generalized null cusp world surface associated to the spinning string solution.
The result corrects and extends the previous conformal gauge result of
arXiv:0712.2479 and is found to be in complete agreement with the corresponding
terms in the generalized scaling function as obtained from the asymptotic Bethe
ansatz in arXiv:0805.4615 (and also partially from the quantum O(6) model and
the Bethe ansatz data in arXiv:0809.4952). This provides a highly nontrivial
strong coupling comparison of the Bethe ansatz proposal with the quantum AdS_5
x S^5 superstring theory, which goes beyond the leading semiclassical term
effectively controlled by the underlying algebraic curve. The 2-loop
computation we perform involves all the structures in the AdS light-cone gauge
superstring action of hep-th/0009171 and thus tests its ultraviolet finiteness
and, through the agreement with the Bethe ansatz, its quantum integrability. We
do most of the computations for a generalized spinning string solution or the
corresponding null cusp surface that involves both the orbital momentum and the
winding in a large circle of S^5.Comment: 50 pages, late
Cerebral tuberculomas in aids patients - A forgotten diagnosis?
The human immunodeficiency virus (HIV) infection epidemics increased the prevalence, multi-drug resistance and disseminated forms of tuberculosis. The central nervous system (CNS) tuberculosis has high mortality and morbidity, and it is usually divided into diffuse (meningitis) and localized (tuberculoma and abscess) forms. We report three cases of cerebral tuberculomas in AIDS patients: one with definitive diagnosis, confirmed with histopathology, and two with probable diagnosis, based on clinical information, radiological images, Mycobaterium tuberculosis isolation out of the CNS and adequate response to antituberculous treatment. Further, we discuss diagnostic, therapeutic and prognostic issues of tuberculomas, with emphasis in the distinction from cerebral tuberculous abscesses. Despite of their infrequent presentation, tuberculomas should be considered in the differential diagnosis of cerebral expansive lesions in patients with AIDS.623B79379
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