3,353 research outputs found
An explanation for a universality of transition temperatures in families of copper oxide superconductors
A remarkable mystery of the copper oxide high-transition-temperature (Tc)
superconductors is the dependence of Tc on the number of CuO2 layers, n, in the
unit cell of a crystal. In a given family of these superconductors, Tc rises
with the number of layers, reaching a peak at n=3, and then declines: the
result is a bell-shaped curve. Despite the ubiquity of this phenomenon, it is
still poorly understood and attention has instead been mainly focused on the
properties of a single CuO2 plane. Here we show that the quantum tunnelling of
Cooper pairs between the layers simply and naturally explains the experimental
results, when combined with the recently quantified charge imbalance of the
layers and the latest notion of a competing order nucleated by this charge
imbalance that suppresses superconductivity. We calculate the bell-shaped curve
and show that, if materials can be engineered so as to minimize the charge
imbalance as n increases, Tc can be raised further.Comment: 15 pages, 3 figures. The version published in Natur
Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells
Background: The sestrin family of stress-responsive genes (SESN1-3) are suggested to be involved in regulation of metabolism and aging through modulation of the AMPK-mTOR pathway. AMP-activated protein kinase (AMPK) is an effector of the tumour suppressor LKB1, which regulates energy homeostasis, cell polarity, and the cell cycle. SESN1/2 can interact directly with AMPK in response to stress to maintain genomic integrity and suppress tumorigenesis. Ionizing radiation (IR), a widely used cancer therapy, is known to increase sestrin expression, and acutely activate AMPK. However, the regulation of AMPK expression by sestrins in response to IR has not been studied in depth. Methods and Findings: Through immunoprecipitation we observed that SESN2 directly interacted with the AMPKa1b1c1 trimer and its upstream regulator LKB1 in MCF7 breast cancer cells. SESN2 overexpression was achieved using a Flag-tagged SESN2 expression vector or a stably-integrated tetracycline-inducible system, which also increased AMPKa1 and AMPKb1 subunit phosphorylation, and co-localized with phosphorylated AMPKa-Thr127 in the cytoplasm. Furthermore, enhanced SESN2 expression increased protein levels of LKB1 and AMPKa1b1c1, as well as mRNA levels of LKB1, AMPKa1, and AMPKb1. Treatment of MCF7 cells with IR elevated AMPK expression and activity, but this effect was attenuated in the presence of SESN2 siRNA. In addition, elevated SESN2 inhibited IR-induced mTOR signalling and sensitized MCF7 cells to IR through an AMPK-dependent mechanism
Light dark matter and dark force at colliders
Light Dark Matter, GeV, with sizable direct detection rate is an
interesting and less explored scenario. Collider searches can be very powerful,
such as through the channel in which a pair of dark matter particle are
produced in association with a jet. It is a generic possibility that the
mediator of the interaction between DM and the nucleus will also be accessible
at the Tevatron and the LHC. Therefore, collider search of the mediator can
provide a more comprehensive probe of the dark matter and its interactions. In
this article, to demonstrate the complementarity of these two approaches, we
focus on the possibility of the mediator being a new gauge boson, which
is probably the simplest model which allows a large direct detection cross
section for a light dark matter candidate. We combine searches in the
monojet+MET channel and dijet resonance search for the mediator. We find that
for the mass of between 250 GeV and 4 TeV, resonance searches at the
colliders provide stronger constraints on this model than the monojet+MET
searches.Comment: 23 pages and 14 figure
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Comparisons of host mitochondrial, nuclear and endosymbiont bacterial genes reveal cryptic fig wasp species and the effects of Wolbachia on host mtDNA evolution and diversity
Background
Figs and fig-pollinating wasp species usually display a highly specific one-to-one association. However, more and more studies have revealed that the "one-to-one" rule has been broken. Co-pollinators have been reported, but we do not yet know how they evolve. They may evolve from insect speciation induced or facilitated by Wolbachia which can manipulate host reproduction and induce reproductive isolation. In addition, Wolbachia can affect host mitochondrial DNA evolution, because of the linkage between Wolbachia and associated mitochondrial haplotypes, and thus confound host phylogeny based on mtDNA. Previous research has shown that fig wasps have the highest incidence of Wolbachia infection in all insect taxa, and Wolbachia may have great influence on fig wasp biology. Therefore, we look forward to understanding the influence of Wolbachia on mitochondrial DNA evolution and speciation in fig wasps.
Results
We surveyed 76 pollinator wasp specimens from nine Ficus microcarpa trees each growing at a different location in Hainan and Fujian Provinces, China. We found that all wasps were morphologically identified as Eupristina verticillata, but diverged into three clades with 4.22-5.28% mtDNA divergence and 2.29-20.72% nuclear gene divergence. We also found very strong concordance between E. verticillata clades and Wolbachia infection status, and the predicted effects of Wolbachia on both mtDNA diversity and evolution by decreasing mitochondrial haplotypes.
Conclusions
Our study reveals that the pollinating wasp E. verticillata on F. microcarpa has diverged into three cryptic species, and Wolbachia may have a role in this divergence. The results also indicate that Wolbachia strains infecting E. verticillata have likely resulted in selective sweeps on host mitochondrial DNA
Generating MHV super-vertices in light-cone gauge
We constructe the SYM lagrangian in light-cone gauge using
chiral superfields instead of the standard vector superfield approach and
derive the MHV lagrangian. The canonical transformations of the gauge field and
gaugino fields are summarised by the transformation condition of chiral
superfields. We show that MHV super-vertices can be described
by a formula similar to that of the MHV super-amplitude. In the
discussions we briefly remark on how to derive Nair's formula for
SYM theory directly from light-cone lagrangian.Comment: 25 pages, 7 figures, JHEP3 style; v2: references added, some typos
corrected; Clarification on the condition used to remove one Grassmann
variabl
Axion-like-particle search with high-intensity lasers
We study ALP-photon-conversion within strong inhomogeneous electromagnetic
fields as provided by contemporary high-intensity laser systems. We observe
that probe photons traversing the focal spot of a superposition of Gaussian
beams of a single high-intensity laser at fundamental and frequency-doubled
mode can experience a frequency shift due to their intermittent propagation as
axion-like-particles. This process is strongly peaked for resonant masses on
the order of the involved laser frequencies. Purely laser-based experiments in
optical setups are sensitive to ALPs in the mass range and can
thus complement ALP searches at dipole magnets.Comment: 25 pages, 2 figure
Exploring the Higgs Portal with 10/fb at the LHC
We consider the impact of new exotic colored and/or charged matter
interacting through the Higgs portal on Standard Model Higgs boson searches at
the LHC. Such Higgs portal couplings can induce shifts in the effective
Higgs-gluon-gluon and Higgs-photon-photon couplings, thus modifying the Higgs
production and decay patterns. We consider two possible interpretations of the
current LHC Higgs searches based on ~ 5/fb of data at each detector: 1) a Higgs
boson in the mass range (124-126) GeV and 2) a `hidden' heavy Higgs boson which
is underproduced due to the suppression of its gluon fusion production cross
section. We first perform a model independent analysis of the allowed sizes of
such shifts in light of the current LHC data. As a class of possible candidates
for new physics which gives rise to such shifts, we investigate the effects of
new scalar multiplets charged under the Standard Model gauge symmetries. We
determine the scalar parameter space that is allowed by current LHC Higgs
searches, and compare with complementary LHC searches that are sensitive to the
direct production of colored scalar states.Comment: 27 pages, 11 figures; v2: references added, correction to scalar form
factor, numerical results updated with Moriond 2012 data, conclusions
unchange
Detection of Ligation Products of DNA Linkers with 5′-OH Ends by Denaturing PAGE Silver Stain
To explore if DNA linkers with 5′-hydroxyl (OH) ends could be joined by commercial T4 and E. coli DNA ligase, these linkers were synthesized by using the solid-phase phosphoramidite method and joined by using commercial T4 and E. coli DNA ligases. The ligation products were detected by using denaturing PAGE silver stain and PCR method. About 0.5–1% of linkers A–B and E–F, and 0.13–0.5% of linkers C–D could be joined by T4 DNA ligases. About 0.25–0.77% of linkers A–B and E–F, and 0.06–0.39% of linkers C–D could be joined by E. coli DNA ligases. A 1-base deletion (-G) and a 5-base deletion (-GGAGC) could be found at the ligation junctions of the linkers. But about 80% of the ligation products purified with a PCR product purification kit did not contain these base deletions, meaning that some linkers had been correctly joined by T4 and E. coli DNA ligases. In addition, about 0.025–0.1% of oligo 11 could be phosphorylated by commercial T4 DNA ligase. The phosphorylation products could be increased when the phosphorylation reaction was extended from 1 hr to 2 hrs. We speculated that perhaps the linkers with 5′-OH ends could be joined by T4 or E. coli DNA ligase in 2 different manners: (i) about 0.025–0.1% of linkers could be phosphorylated by commercial T4 DNA ligase, and then these phosphorylated linkers could be joined to the 3′-OH ends of other linkers; and (ii) the linkers could delete one or more nucleotide(s) at their 5′-ends and thereby generated some 5′-phosphate ends, and then these 5′-phosphate ends could be joined to the 3′-OH ends of other linkers at a low efficiency. Our findings may probably indicate that some DNA nicks with 5′-OH ends can be joined by commercial T4 or E. coli DNA ligase even in the absence of PNK
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Bulk properties of the system formed in Au+Au collisions at sNN =14.5 GeV at the BNL STAR detector
We report systematic measurements of bulk properties of the system created in Au+Au collisions at sNN=14.5 GeV recorded by the STAR detector at the Relativistic Heavy Ion Collider (RHIC). The transverse momentum spectra of π±, K±, and p(p) are studied at midrapidity (|y|<0.1) for nine centrality intervals. The centrality, transverse momentum (pT), and pseudorapidity (η) dependence of inclusive charged particle elliptic flow (v2), and rapidity-odd charged particles directed flow (v1) results near midrapidity are also presented. These measurements are compared with the published results from Au+Au collisions at other energies, and from Pb+Pb collisions at sNN=2.76 TeV. The results at sNN=14.5 GeV show similar behavior as established at other energies and fit well in the energy dependence trend. These results are important as the 14.5-GeV energy fills the gap in μB, which is of the order of 100 MeV, between sNN=11.5 and 19.6 GeV. Comparisons of the data with UrQMD and AMPT models show poor agreement in general
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