CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1 plays a dual role in two apparently unrelated processes, inhibiting local protein synthesis and favoring actin remodeling. Here, we show that brain-derived neurotrophic factor (BDNF)-driven synaptic signaling releases CYFIP1 from the translational inhibitory complex, triggering translation of target mRNAs and shifting CYFIP1 into the WAVE regulatory complex. Active Rac1 alters the CYFIP1 conformation, as demonstrated by intramolecular FRET, and is key in changing the equilibrium of the two complexes. CYFIP1 thus orchestrates the two molecular cascades, protein translation and actin polymerization, each of which is necessary for correct spine morphology in neurons. The CYFIP1 interactome reveals many interactors associated with brain disorders, opening new perspectives to define regulatory pathways shared by neurological disabilities characterized by spine dysmorphogenesis.status: publishe

A stem-loop-mediated reverse transcription real-time PCR for the selective detection and quantification of the replicative strand of an RNA virus

10.1016/j.ab.2006.01.046Analytical Biochemistry3521120-128ANBC

Prediction of class I T-cell epitopes: Evidence of presence of immunological hot spots inside antigens

10.1093/bioinformatics/bth943Bioinformatics20SUPPL. 1i297-i302BOIN

Computational models for identifying promiscuous HLA-B7 binders based on information theory and support vector machine

10.1109/ICBPE.2006.348607ICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering319-32

Temporal and antigenic analysis of dengue virus serotype 1 genome polyprotein sequences

10.1109/ICBPE.2006.348604ICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering301-30

Biblical commentary on the New Testament /

"Only the synoptical Gospels have, in the original, been carried throught the fourth eedition. Other portions...have reached a third, others a second edition."--Prefatory note, v. 4.Vol. 4: First American edition, revised after the latest German edition, by A. C. Kendrick: v. 5-6: Continued after his [the author's] death by Dr. John Henry Augustus Ebrard and He. Augustus Wiesinger ... Revised after the latest German edition, by A. C. Kendrick.Mode of access: Internet