8 research outputs found
Comparative Analysis of the Effects of a Novel Vacuolar Adenosine 5âČ-Triphosphatase Inhibitor, FR202126, and Doxycycline on Bone Loss Caused by Experimental Periodontitis in Rats
ASYMPTOTIC SERIES FOR DOUBLE ZETA AND DOUBLE GAMMA FUNCTIONS OF BARNES(Analytic Number Theory)
Study design, dosing duration, dosage strength, regimen and formulation of OCEAN, PKPD and PK studies. (DOCX 71ĂÂ kb
Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711
Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica
The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cathepsin L3 (FhCL3), liver migrating juvenile parasites secrete both FhCL1 and FhCL2 while the mature bile duct parasites, which are obligate blood feeders, secrete predominantly FhCL1 but also FhCL2