Finite temperature effects on the antikaon optical potential

By solving the Bethe-Goldstone equation, we have obtained the $\bar{K}$ optical potential from the $\bar{K}N$ effective interaction in nuclear matter at T=0. We have extended the model by incorporating finite temperature effects in order to adapt our calculations to the experimental conditions in heavy-ion collisions. In the rank of densities ($0-2\rho_0$), the finite temperature $\bar{K}$ optical potential shows a smooth behaviour if we compare it to the T=0 outcome. Our model has also been applied to the study of the ratio between $K^+$ and $K^-$ produced at GSI with $T$ around 70 MeV. Our results point at the necessity of introducing an attractive $\bar{K}$ optical potential.Comment: 7 pages, 4 figures. Contribution to the proceedings of Mesons & Light Nuclei '01 (2-6th July, Prague

Usage And Efficacy Of Social Media Marketing Tools: An Investigation Of College Age Student’s Behaviors

This study looks at social media marketing techniques used by the world’s top companies to determine their effectiveness on college age consumers. Social media use is becoming increasingly important with the advent of social media platforms such as Facebook and Twitter. This research first defines the social media marketing strategies done on social media, and then measures the effectiveness of each strategy on college students. This research also attempts to see if there is a relationship between personality and the effectiveness of certain social media marketing strategies

The early compositions for cello and piano by Heitor Villa-Lobos

This study presents a historical overview of Heitor Villa-Lobos’s early life, career, surrounding environment, influences, selected early compositions for cello and piano written between 1913 and 1917, autographs, and of Rio de Janeiro from the late 19th and early 20th centuries. In the study of Villa-Lobos’s early life and Rio de Janeiro from the late 19th and early 20th centuries, it is important to consider the influences of Europe, especially France on Brazil, and European composers on Heitor Villa-Lobos. This study provides historical information, and attempts to increase the dissemination of Villa-Lobos’s early compositions for cello and piano into the standard cello repertoire. The study also presents information to help cellists understand and then incorporate these pieces into their repertoire, followed by a recording of selected Villa-Lobos’s early compositions for cello and piano performed by this author. More pertinent materials are given in the appendixes, such as historical information about the other compositions for cello and piano written between 1913 and 1917 (Appendix A), and a complete list of compositions for and with cello by Heitor Villa-Lobos (Appendix B). The findings of this study show that Villa-Lobos’s early compositions for cello and piano show a complete absence of elements of Brazilian folklore, were highly influenced by the aesthetics of European composers in vogue at the time in Brazil, and were written while the composer was active as a cellist As shown in the Conclusion, after careful analysis, it can be inferred that Villa-Lobos’s early compositions for cello and piano deserve to be known, incorporated into the repertoire of modern cellists, and performed more frequently

Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.

Progress in the management of patients with myelodysplastic syndromes (MDS) has been hampered by the inability to detect cytogenetic abnormalities in 40-60% of cases. We prospectively analyzed matched pairs of bone marrow and buccal cell (normal) DNA samples from 51 MDS patients by single nucleotide polymorphism (SNP) arrays, and identified somatically acquired clonal genomic abnormalities in 21 patients (41%). Among the 33 patients with normal bone marrow cell karyotypes, 5 (15%) had clonal, somatically acquired aberrations by SNP array analysis, including 4 with segmental uniparental disomies (UPD) and 1 with three separate microdeletions. Each abnormality was detected more readily in CD34+ cells than in unselected bone marrow cells. Paired analysis of bone marrow and buccal cell DNA from each patient was necessary to distinguish true clonal genomic abnormalities from inherited copy number variations and regions with apparent loss of heterozygosity. UPDs affecting chromosome 7q were identified in two patients who had a rapidly deteriorating clinical course despite a low-risk International Prognostic Scoring System score. Further studies of larger numbers of patients will be needed to determine whether 7q UPD detected by SNP array analysis will identify higher risk MDS patients at diagnosis, analogous to those with 7q cytogenetic abnormalities

Impact of Age on Treatment and Outcomes After Acute Myocardial Infarction, Particularly in Very Elderly Patients

INTRODUCTION: The elderly population admitted for acute myocardial infarction is increasing. This group is not well studied in international trials and is probably treated with a more conservative approach. OBJECTIVES: To evaluate the presentation and treatment of myocardial infarction according to age, particularly in very elderly patients. METHODS: We studied 1242 consecutive patients admitted with acute myocardial infarction, assessing in-hospital, 30-day and one-year mortality during follow-up for each age-group. Patients were divided into four groups according to age: <45 years (7.6%); 45-64 years (43.3%); 65-74 years (23.4%); and ≥75 years (25.7%). RESULTS: Elderly patients had a worse risk profile (except for smoking), more previous history of coronary disease and a worse profile on admission, with the exception of lipid profile, which was more favorable. With regard to treatment of the elderly, although less optimized than in other age-groups, it was significantly better compared to other registries, including for percutaneous coronary angioplasty. Both complications and mortality were worse in the older groups. In elderly patients (≥75 years), adjusted risk of mortality was 4.9-6.3 times higher (p<0.001) than patients in the reference age-group (45-64 years). In these patients, the independent predictors of death were left ventricular function and renal function, use of beta-blockers being a predictor of survival. CONCLUSIONS: Elderly patients represent a substantial proportion of the population admitted with myocardial infarction, and receive less evidenced-based therapy. Age is an independent predictor of short- and medium-term mortality

Does Admission NT-ProBNP Increase the Prognostic Accuracy of GRACE Risk Score in the Prediction of Short-Term Mortality After Acute Coronary Syndromes?

BACKGROUND: NT-proBNP has prognostic implications in heart failure. In acute coronary syndromes (ACS) setting, the prognostic significance of NT-proBNP is being sought. We studied short-term prognostic impact of admission NT-proBNP in patients admitted for ACS and in association with GRACE risk score (GRS). METHODS AND RESULTS: We studied 1035 patients admitted with ACS. Patients were divided in quartiles according to NT-proBNP levels on admission: Q1 <180 pg/ml; Q2 180-691 pg/ml; Q3 696-2664 pg/ml; Q4 2698-35 000 pg/ml. Groups were compared in terms of short-term all-cause mortality. Patients with higher NT-proBNP had worst GRS on admission. They also received less aggressive treatment. In-hospital mortality was 0.8%, 3.0%, 5.8% and 12.8% (P<0.001) and 30-day mortality 1.6%, 4.6%, 6.5% and 16.7% (P<0.001) respectively. In multivariate logistic regression analysis, NT-proBNP is an independent predictor of in-hospital (OR 2.35; 95% CI: 1.12-4.93, P=0.022) and 30-day mortality (OR 2.20; 95% CI: 1.17-4.12, P=0.014). However, NT-proBNP does not add any incremental benefit to GRS for prediction of outcome by ROC curve analysis. CONCLUSIONS: NT-proBNP is an independent predictor of in-hospital and 30-day mortality after ACS, independently of left ventricular function, but does not increase the prognostic accuracy of GRS.info:eu-repo/semantics/publishedVersio

Impact of Obesity on Results after Primary Angioplasty in Patients with ST Segment Elevation Acute Myocardial Infarction

INTRODUCTION: Obesity is an important risk factor for the development of diabetes, hypertension, coronary disease, left ventricular dysfunction, stroke and cardiac arrhythmias. Paradoxically, previous studies in patients undergoing elective coronary angioplasty showed a reduction in hospital and long-term mortality in obese patients. The relation with body mass index (BMI) has been less studied in the context of primary angioplasty. OBJECTIVES: To evaluate the impact of obesity on the results of ST-segment elevation acute myocardial infarction treated by primary angioplasty. METHODS: This was a study of 464 consecutive patients with ST-segment elevation acute myocardial infarction undergoing primary angioplasty, 78% male, mean age 61 +/- 13 years. We assessed in-hospital, 30-day and one-year mortality according to BMI. Patients were divided into three groups according to BMI: normal--18-24.9 kg/m2 (n = 171); overweight--25-29.9 kg/m2 (n = 204); and obese-- > 30 kg/m2 (n = 89). RESULTS: Obese patients were younger (ANOVA, p < 0.001) and more frequently male (p = 0.014), with more hypertension (p = 0.001) and dyslipidemia (p = 0.006). There were no differences in the prevalence of diabetes, previous cardiac history, heart failure on admission, anterior location, multivessel disease, peak total CK or medication prescribed, except that obese patients received more beta-blockers (p = 0.049). In-hospital mortality was 9.9% for patients with normal BMI, 3.4% for overweight patients and 6.7% for obese patients (p = 0.038). Mortality at 30 days was 11 4.4% and 7.8% (p = 0.032) and at one year 12.9%, 4.9% and 9% (p = 0.023), respectively. On univariate analysis, overweight was the only BMI category with a protective effect; however, after multivariate logistic regression analysis, adjusted for confounding variables, none of the BMI categories could independently predict outcome. CONCLUSIONS: Overweight patients had a better prognosis after primary angioplasty for ST-segment elevation acute myocardial infarction compared with other BMI categories, but this was dependent on other potentially confounding variables

A potential role for naringenin in reversing tamoxifen resistance in MCF-7 breast cancer cells

Tamoxifen has been used as an effective treatment against breast cancer for over 30 years. However, tamoxifen resistance has become a major hurdle to effective treatment. Previous studies have implicated up-regulation of the PI3K and MAPK pathways as being involved in the growth exhibited by tamoxifen resistant cells. Data from our lab and others have shown naringenin to have the ability to impair both of these signaling pathways. For this study, I investigated whether naringenin, a flavanone, could reverse the proliferation observed in tamoxifen-resistant cells (TAM-R). MCF-7 cells were exposed to low levels of 4-OH-tamoxifen (1 µM) for 10 months in order to generate a tamoxifen-resistant cell line, TAM-R. These cells were then cultured under various combinations of treatment with tamoxifen and naringenin. TAM-R cells demonstrated a clear ability to proliferate in the presence of tamoxifen as measured using cell counting and an MTT assay. However, the addition of naringenin reversed that proliferation. The TAM-R cells also exhibited an up-regulation of the MAPK pathway which was also reversed by treatment with naringenin as measured by western blot analysis. In addition, treatment with tamoxifen and naringenin together led to a greater reduction in cell growth than either treatment alone. Confocal microscopy was also employed to look for any changes in the localization patterns of the estrogen receptor alpha (ER&amp;alpha;). ER&amp;alpha; was found predominantly in the nucleus in MCF-7 cells. Upon treatment with tamoxifen, this pattern changed to a peri-nuclear localization. Once the cells attained tamoxifen resistance, the ER&amp;alpha; displayed an even pattern across the cell. However, upon treatment of the TAM-R cells with naringenin, the ER&amp;alpha; localization returned to a peri-nuclear pattern similar to that seen in the tamoxifen-sensitive cells. The results from this study clearly demonstrate the ability of naringenin to reverse the proliferation normally seen in TAM-R cells. Naringenin also appears to have a synergistic effect with tamoxifen on growth impairment. There is also evidence these changes are taking place through the MAPK pathway. Taken together, these results open up the possibility of treatment with naringenin as a means to combat tamoxifen resistance

Bridging identities : solo oboe and chamber works by Mexican composers

I. Solo Recital: Saturday, October 17, 2020, 5:30 p.m, Tew Recital Hall. Oboe Concerto: Rondo Pastorale, Finale (Scherzo) (Ralph Vaughan Williams); Obsession (Makoto Shinohara); Brokenvention (Alyssa Morris); Spell Song (Toshio Hosokawa); Italian Dance (Madeleine Dring). II. Solo Recital: Tuesday, April 13, 2021, 7:30 p.m, Tew Recital Hall. Sueños de Crisálida (Allesandra Vargas), Oboe Concerto in a minor, RV 461 (Antonio Vivaldi), Oboe Concerto: Allegro Moderato quasi Pastorale, Adagio (David Mullikin); Summer Song (Miguel del Águila). III. Solo Recital: Sunday, April 24, 2022, 11:30 a.m, Tew Recital Hall. Al filo del agua (Maria Granillo); Night Windows: Anger, Nostalgia (Thea Musgrave); Boca abajo (Francisco Cortés-Álvarez); Parking Violation: 42nd Street and Queens Boulevard, West Broadway &amp; Franklin Street, 42nd Street &amp; Greenpoint Avenue, 96th Street &amp; Broadway, 42nd Street &amp; 47th Avenue (Mark Mellits); Danza de Mediodía (Arturo Márquez). IV. D.M.A Research Project. BRIDGING IDENTITIES: SOLO OBOE AND CHAMBER WORKS BY MEXICAN COMPOSERS, (2023). The purpose of this project was to make known various oboe solo and chamber works by Mexican composers and to establish the beginnings of a communications network between oboists and these same composers. For each of the ten pieces in the dissertation a performance analysis was conducted and a playing level assigned. Composers were introduced via biographies and transcribed interviews. The following questions were addressed in this project. How many pieces for the oboe by Mexican composers exist? Is there a resource to search for these compositions other than a blind internet search? How do I obtain the music for these pieces? What oboe techniques are needed to perform these pieces? As the project was conducted and pieces compiled, other than two albums dedicated to oboe works by Mexican composers, Carmen Thierry’s Oboemia: Música Mexicana para Oboe Solo and Jonathan Thompsons’ Tollan: Mexican Works for the Oboe, three other resources found were found. Two of these are student theses which also focused on oboe works by Mexican composers, Alejandra Odgers’ La Música de Cámara Para Oboe Escrita En La Segunda Mitad Del Siglo XX, and Mireya Pérez Fernández’s Música Mexicana Inédita Para Oboe. Grabación Digital, Comentarios Analíticos Y Partituras. The third resource is a catalog of Mexican oboe works, Catalog of Mexican Oboe Music, compiled by oboist Jonathan Thompson. However, since the theses were discovered in the middle of the project and the catalog was only acquired towards the end of the project, all pieces included in the dissertation were found in two albums mentioned above or via individual internet searches. Music was obtained mostly by contacting the composers directly; only five out of ten pieces were procured in separate publishing websites. There are a variety of extended oboe techniques needed for these pieces as well. These include glissandi, pitch bending, quarter tones and micro tones, flutter tonguing, multiphonics, tremolos, and double tonguing

Utilidade do Strain Bidimensional por Speckle Tracking da Aurícula e Ventrículo Direito para Predizer Arritmias Tardias em Doentes Adultos com Tetralogia de Fallot Corrigida

OBJECTIVE: To determine whether right ventricular and/or atrial speckle tracking strain is associated with previous arrhythmic events in patients with repaired tetralogy of Fallot. METHODS AND RESULTS: We studied right ventricular and atrial strain in 100 consecutive patients with repaired tetralogy of Fallot referred for routine echocardiographic evaluation. Patients were divided into two groups, one with previous documentation of arrhythmias (n=26) and one without arrhythmias, in a median follow-up of 22 years. Patients with arrhythmias were older (p<0.001) and had surgical repair at an older age (p=0.001). They also had significantly reduced right ventricular strain (-14.7±5.5 vs. -16.9±4.0%, p=0.029) and right atrial strain (19.1±7.7% vs. 25.8±11.4%, p=0.001). Neither right ventricular nor right atrial strain were independent predictors of the presence of a history of documented arrhythmias, which was associated with age at correction and with the presence of residual defects. In a subanalysis after excluding 23 patients who had had more than one corrective surgery, right ventricular strain was an independent predictor of the presence of previous arrhythmic events (OR 1.19, 95% CI 1.02-1.38, p=0.025). Right atrial strain was also an independent predictor after adjustment (OR 0.93, 95% CI 0.87-0.99, p=0.029). The ideal cut-off for right ventricular strain was -15.3% and for right atrial strain 23.0%. CONCLUSIONS: Compared with conventional echocardiographic parameters, strain measures of the right heart are associated with the presence of arrhythmic events, and may be useful for risk stratification of patients with repaired tetralogy of Fallot, although a prospective study is required.info:eu-repo/semantics/publishedVersio