The multinational corporation : its effects on the American labor force

With the advent of the 1970's a new development arose upon the international economic scene, that of the American multinational corporation. In the wake of this development numerous economic effects with respect to employment, income, and labor standards resulted. These effects have had and will continue to have a profound impact upon the American labor force. It was the purpose of this thesis to investigate the operations of this new corporate concept with a thorough exploration of its effects upon American labor. It was hypothesized that unemployment could result from the outflows of capital and technology by multi-nationals . The procedures employed were two: An intensive investigation of the recent literature on labor and international economics was made: Similarly, current statistical data were gathered. However, no complex statistical correlations were utilized. Presentation of both organized labor's and the corporation's arguments was made. An objective viewpoint was then attempted by the writer. Due to the unavailability of relevant data on this phenomenon, the results of this study were necessarily inconclusive. Conditionally, it was concluded that unemployment was likely to be felt in the American labor force when direct multinational investment was permitted. Nevertheless, these effects might be mitigated as income from this investment flowed back to the American economy. Enough information was presented, however, to suggest that American labor standards and wage conditions must become, the international norm in order to counteract any such effects. Protectionist proposals, as embodied in the pending Burke-Hartke Act, were rejected as less desirable

Airplanes are always girls

My work arises from the process of extracting content from real events. I reassemble this content and transform it into the components comprising my installation, entitled I Can See Your House From Up Here. The subject for my thesis is centered on a continuing atrocity that occurs beyond my immediate proximity, specifically the American invasion of Iraq beginning in 1990 during the Persian Gulf War. My experience of the war is mediated and incomplete; it is constructed from partial narratives and a distorted picture of ostensibly real events. I am removed from this atrocity as a result of geographical distance and political circumstance. Using the imagery from magazines, newspapers, internet search engines, propaganda material, military documents, surveillance footage, and published satellite imagery of the surface of Iraq, I attempt to reconstruct yet another incomplete narrative of imagined events in an attempt to explore social constructs relating to gender militarization. My personal experiences relating to oppressive and uncontrollable events are manifested in the form of an installation. I Can See Your House From Up Here was composed using a variety of salvaged materials including paper, wire, and cardboard

Ethnicity, gender, and high school dropouts : a case study

High school dropout, or early school withdrawal, is a complex problem that can result from factors in all life domains. Specific factors commonly cited throughout literature in association with early school withdrawal include socioeconomic status, school mobility, and grade retention among others. There is also evidence suggesting that the factors influencing the decision to drop out of school for African American and Hispanic students may differ from the factors that influence White students. Research is conflicting as to specific gender differences among high school dropouts and with regard to the factors that influence such a decision between males and females. This study examined differences in self-reported reasons for prematurely withdrawing from school between minority status (African American and Hispanic) and non-minority status (White) students, as well as between males and females. An additional focus of this study was on school mobility and grade retention as they relate to minority status and impact high school dropout. Results indicate no significant results with regard to: minority status and high school dropout, minority status and factors related to high school dropout, school mobility and minority status, grade retention and minority status, or gender and factors related to high school dropout. However, as hypothesized, within this sample of high school dropouts, there was a significantly higher proportion of males, students who have experienced school mobility and students who have been retained. These findings support much of the research which suggests that males tend to drop out of school at a higher rate than females and that both school mobility and grade retention are plausible predictors of high school dropout. However, no support was provided for minority status as being a significant factor

Global Effect of COVID-19 on Small Businesses

COVID-19 is a worldwide pandemic that started in December 2019 in China. Smallbusinesses all over the world had no idea where to turn to, where their capital would go and whatto expect from a teeter-totter economy. With the help of government incentives and results fromsurveys such as the Small Business Pulse Survey as well as the Current Population Survey, Inthis study the following were concluded: 1) partaking in government incentives may better thebusiness, 2) having an online e-commerce presence may make or break the company, and 3)redesigning the business to work with the “new normal” may help define their niche and have athriving business

Erosion and the sediment conveyor in central Australia

Why are the Neogene sedimentary fills across central Australia generally thin and discontinuous? One long-standing explanation is that sluggish tectonism and intensified aridity have combined to suppress rates of erosion and sediment production yielding a landscape crowded with inherited, preMiocene forms. Quantifying rates of sediment production, residence time and transport is possible with numerous methods, but the recent growth of cosmogenic nuclide (CN) analysis has provided unprecedented quantitative insights to rates of landscape evolution. Measurements of in situ produced cosmogenic 10Be and 26Al integrate rates of surface processes over million-year timescales—the last part of the Neogene in which aridity has strengthened across the continental interior. We present a compilation of ~600 published and unpublished 10Be and 26Al measurements from central Australia with a focus on the Neogene Eyre Basin and its periphery. Outlying and inlying bedrock uplands serve as engines of sediment production via erosion of bedrock. Surrounding the bedrock outcrops are vast sediment conveyors of varying efficiency and tempo: hillslopes, pediments, and alluvial fans are interim storage/burial zones for sediment in transit to the network of low-gradient rivers, dunes, and playas towards base level. Interactions between fluvial and aeolian processes are especially pertinent to sediment flux in the Eyre Basin. Major rivers such as the Cooper and Finke traverse dunefields in their lower reaches where quantities of alluvia are recirculated into dunes and vice versa. Tracking the trajectories of sediment from source-to-sink (including aeolian recirculation) remains a major challenge, but is central to unravelling the sedimentary dynamics of central Australia's Neogene basins. Based on the CN compilation we estimate 1) spatially averaged erosion rates at the scale of a hillslope or river catchment; 2) pointbased erosion rates on bedrock surfaces; 3) residence time of sediment in hillslope regolith and alluvial fans; and 4) cumulative burial history of sediments in transit. Catchment-scale erosion rates (n~100) are consistently low (<10 m/Myr) and include some of the lowest rates ever measured (~0.3 m/Myr); however, a small group of catchments in the Flinders Ras yield higher erosion rates (~30–60 m/Myr). Bedrock hillslopes (n~200) tend to erode even slower (<5 m/Myr), with a subset of Flinders Ras sites again being the exception (~10–30 m/Myr) and suggesting the influence of recent tectonism. Several CN depth-profiles measured on hillslopes and alluvial fans indicate sediment residence times >0.5 Myr, and high-resolution sampling along three hillslopes with differing morphology (linear, convex, and concave) reveals major variations in sediment production and transport rates that hint at the long-term evolution. In the rivers, fluvial sediments show a weak tendency to increase cumulative burial history downstream (1–2 Myr), consistent with the expanding accommodation space for storage and burial. Dune sediments sampled in the Simpson and Tirari dunefields (n~16) contain cumulative burial histories (up to 1.5 Myr) similar to that of the intersecting rivers. This points to an intimate mix of fluvial and aeolian processes in areas approaching base level. Curiously, these sediments occur in the lowest part of the continent and contain the longest histories of cumulative burial, yet do not form part of the thickest sedimentary fills in the Eyre Basin

Contribution of the Type VI Secretion System Encoded in SPI-19 to Chicken Colonization by Salmonella enterica Serotypes Gallinarum and Enteritidis

Salmonella Gallinarum is a pathogen with a host range specific to poultry, while Salmonella Enteritidis is a broad host range pathogen that colonizes poultry sub-clinically but is a leading cause of gastrointestinal salmonellosis in humans and many other species. Despite recent advances in our understanding of the complex interplay between Salmonella and their hosts, the molecular basis of host range restriction and unique pathobiology of Gallinarum remain largely unknown. Type VI Secretion System (T6SS) represents a new paradigm of protein secretion that is critical for the pathogenesis of many Gram-negative bacteria. We recently identified a putative T6SS in the Salmonella Pathogenicity Island 19 (SPI-19) of Gallinarum. In Enteritidis, SPI-19 is a degenerate element that has lost most of the T6SS functions encoded in the island. In this work, we studied the contribution of SPI-19 to the colonization of Salmonella Gallinarum strain 287/91 in chickens. Non-polar deletion mutants of SPI-19 and the clpV gene, an essential T6SS component, colonized the ileum, ceca, liver and spleen of White Leghorn chicks poorly compared to the wild-type strain after oral inoculation. Return of SPI-19 to the ΔSPI-19 mutant, using VEX-Capture, complemented this colonization defect. In contrast, transfer of SPI-19 from Gallinarum to Enteritidis resulted in transient increase in the colonization of the ileum, liver and spleen at day 1 post-infection, but at days 3 and 5 post-infection a strong colonization defect of the gut and internal organs of the experimentally infected chickens was observed. Our data indicate that SPI-19 and the T6SS encoded in this region contribute to the colonization of the gastrointestinal tract and internal organs of chickens by Salmonella Gallinarum and suggest that degradation of SPI-19 T6SS in Salmonella Enteritidis conferred an advantage in colonization of the avian host

Characterization of human Sec16B: indications of specialized, non-redundant functions

The endoplasmic reticulum (ER) represents the entry point into the secretory pathway and from here newly synthesized proteins and lipids are delivered to the Golgi. The selective cargo export from the ER is mediated by COPII-assembly at specific sites of the ER, the so-called transitional ER (tER). The peripheral membrane protein Sec16, first identified in yeast, localizes to transitional ER and plays a key role in organization of these sites. Sec16 defines the tER and is thought to act as a scaffold for the COPII coat assembly. In humans two isoforms of Sec16 are present, the larger Sec16A and the smaller Sec16B. Nevertheless, the functional differences between the two isoforms are ill-defined. Here we describe characterization of the localization and dynamics of Sec16B relative to Sec16A, provide evidence that Sec16B is likely a minor or perhaps specialized form of Sec16, and that it is not functionally redundant with Sec16A

Decreased expression of the mannose 6- phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells

BACKGROUND: Loss or mutation of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) has been found in breast cancer. However, whether or not decreased levels of functional M6P/IGF2R directly contribute to the process of carcinogenesis needs to be further verified by functional studies. METHODS: In this study, using viral and ribozyme strategies we reduced the expression of M6P/IGF2R in human breast cancer cells and then examined the effect on growth and apoptosis of these cells. RESULTS: Our results showed that infection of MCF-7 cells with the adenovirus carrying a ribozyme targeted against the M6P/IGF2R mRNA dramatically reduced the level of transcripts and the functional activity of M6P/IGF2R in these cells. Accordingly, cells treated with the ribozyme exhibited a higher growth rate and a lower apoptotic index than control cells (infected with a control vector). Furthermore, decreased expression of M6P/IGF2R enhanced IGF-II-induced proliferation and reduced cell susceptibility to TNF-induced apoptosis. CONCLUSIONS: These results suggest that M6P/IGF2R functions as a growth suppressor and its loss or mutation may contribute to development and progression of cancer. This study also demonstrates that adenoviral delivery of the ribozyme provides a useful tool for investigating the role of M6P/IGF2R in regulation of cell growth

Antioxidant properties of MitoTEMPOL and its hydroxylamine

Piperidine nitroxides such as TEMPOL have been widely used as antioxidants in vitro and in vivo. MitoTEMPOL is a mitochondria-targeted derivative of TEMPOL designed to protect mitochondria from the oxidative damage that they accumulate, but once there is rapidly reduced to its hydroxylamine, MitoTEMPOL-H. As little is known about the antioxidant efficacy of hydroxylamines, this study has assessed the antioxidant activity of both MitoTEMPOL and MitoTEMPOL-H. The hydroxylamine was more effective at preventing lipid-peroxidation than MitoTEMPOL and decreased oxidative damage to mitochondrial DNA caused by menadione. In contrast to MitoTEMPOL, MitoTEMPOL-H has no superoxide dismutase activity and its antioxidant actions are likely to be mediated by hydrogen atom donation. Therefore, even though MitoTEMPOL is rapidly reduced to MitoTEMPOL-H in cells, it remains an effective antioxidant. Furthermore, as TEMPOL is also reduced to a hydroxylamine in vivo, many of its antioxidant effects may also be mediated by its hydroxylamine

Multimodal surface-based morphometry reveals diffuse cortical atrophy in traumatic brain injury.

<p>Abstract</p> <p>Background</p> <p>Patients with traumatic brain injury (TBI) often present with significant cognitive deficits without corresponding evidence of cortical damage on neuroradiological examinations. One explanation for this puzzling observation is that the diffuse cortical abnormalities that characterize TBI are difficult to detect with standard imaging procedures. Here we investigated a patient with severe TBI-related cognitive impairments whose scan was interpreted as normal by a board-certified radiologist in order to determine if quantitative neuroimaging could detect cortical abnormalities not evident with standard neuroimaging procedures.</p> <p>Methods</p> <p>Cortical abnormalities were quantified using multimodal surfaced-based morphometry (MSBM) that statistically combined information from high-resolution structural MRI and diffusion tensor imaging (DTI). Normal values of cortical anatomy and cortical and pericortical DTI properties were quantified in a population of 43 healthy control subjects. Corresponding measures from the patient were obtained in two independent imaging sessions. These data were quantified using both the average values for each lobe and the measurements from each point on the cortical surface. The results were statistically analyzed as z-scores from the mean with a p < 0.05 criterion, corrected for multiple comparisons. False positive rates were verified by comparing the data from each control subject with the data from the remaining control population using identical statistical procedures.</p> <p>Results</p> <p>The TBI patient showed significant regional abnormalities in cortical thickness, gray matter diffusivity and pericortical white matter integrity that replicated across imaging sessions. Consistent with the patient's impaired performance on neuropsychological tests of executive function, cortical abnormalities were most pronounced in the frontal lobes.</p> <p>Conclusions</p> <p>MSBM is a promising tool for detecting subtle cortical abnormalities with high sensitivity and selectivity. MSBM may be particularly useful in evaluating cortical structure in TBI and other neurological conditions that produce diffuse abnormalities in both cortical structure and tissue properties.</p