8 research outputs found

    Risk detection of osteoporosis with panoramic radiograph using mental index in 30-60 years old patients (an overview in Ulin Hospital Banjarmasin)

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    Objectives: This research is aimed to determine the detection of osteoporosis risk with a panoramic radiograph using mental index in 30-60 years old patients in Ulin Hospital Banjarmasin. Materials and Methods: This research is using descriptive study with a cross-sectional study design. This research sample using secondary data from 30-60 years old patients who took panoramic radiographs in Radiology Installation of Ulin Hospital Banjarmasin from January 2018 – December 2021. Results: The result showed that the age group at risk of osteoporosis was the age group 56-60 years old (right jaw 3.44 ± 0.70 and left jaw 3.33 ± 0.32), gender at risk of osteoporosis is men (right jaw 3.44 ± 0.52 and left jaw 3.37 ± 0.44) and the mean value of the mandibular cortex width in the group at risk for osteoporosis was 2.91 ± 0.21. Conclusion: The age group at risk of osteoporosis is the age of 56-60 years old and the gender at risk of osteoporosis is men. Mental index can be used as a tool for measuring the mandibular cortex width on panoramic radiographs to diagnose the risk of osteoporosis

    THE TOXICITY OF MAULI BANANA (MUSA ACUMINATA) STEM WATER EXTRACT ON BONE MARROW MESENCHYMAL STEM CELL IN VITRO

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    Objective: Since mesenchymal stem cells (MSC) can differentiate into bone, cementum, and periodontal ligament, they can be used to treat aggressiveperiodontitis. The limited number of MSCs requires replenishment of growth factor in the cell culture process. Since growth factor is quite expensive,an alternative material is needed. Mauli banana stem has antioxidant and immunomodulatory properties. Methanol extract of Mauli banana stem isknown to be toxic toward MSCs; therefore, another solvent with a non-toxic effect is needed, such as a water solvent. We analyzed the toxicity of Maulibanana stem water extract on MSC in vitro.Methods: In this laboratory experimental (true experimental) study with a Post-test Only Control Group Design, MSC cultures were treated withMauli banana stem water extract at 10, 20, 40, 60, 80, and 100 mg/mL dosages. One group without any treatment served as a control group and onewas a media control group. Each group was incubated for 24 h and then was given 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidereagent and analyzed by an enzyme-linked immunosorbent assay (ELISA) reader.Results: One-way analysis of variance showed a significant difference.Conclusion: Mauli banana stem water extracts at 10, 20, 40, and 60 mg/mL were not toxic toward MSC in vitro, while dosages of 80 and 100 mg/mLdosage were toxic

    ANTIBACTERIAL EFFECTIVENESS OF KECAPI SENTUL EXTRACT (SANDORICUM KOETJAPE MERR.) AGAINST STREPTOCOCCUS MUTANS

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    ABSTRACTBackground: One of the causing dental caries is a microorganism, namely Streptococcus mutans. Kecapi sentul leaves extract (Sandoricum koetjape Merr.) contain alkaloid, flavonoid, saponin, steroid, phenol, and triterpenoid which have antibacterial properties on the inhibition Streptococcus mutans which has the potential to prevent dental caries.Method: This research uses a laboratory experimental design with a post-test control group only design, using seven treatment groups, namely kecapi sentul leaves extract with the concentration of group 30%, 40%, 50%, 60%, 70%, Chlorhexidine gluconate 0.2% as positive control and aquadest as negative control were repeated 4 times. Result: Non parametric test Kruskal Wallis and Post Hoc Mann Whitney methods showed that each treatment group was significantly different in the diameter of the formed inhibition zone. The mean diameter of the inhibition zone with a concentration of 30% was 9.1 mm, 40% was 13.3 mm, 50% was 17.13 mm, 60% was 18.65 mm and 70% was 21.05 mm.Conclusion: Kecapi sentul leaves extract (Sandoricum koetjape Merr.) with the concentration of group 30%, 40%, 50%, 60% and 70% have antibacterial potential against the growth of Streptococcus mutans

    FGF-2 expression and the amount of fibroblast in the incised wounds of Rattus norvegicus rats induced with Mauli banana (Musa acuminata) stem extract

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    Background: Traditional wound treatment using herbal medicine is thought to maintain the health of families and society in general economically, effectively, and efficiently without inducing side effects. One genus of plant that can be used as a traditional medicine is the Mauli banana, indigenous to South Borneo. Mauli banana stem contains bioactive compounds, most of which are tannins along with ascorbic acid, saponin, β-carotene, flavonoids, lycopene, alkaloids, and flavonoids. Tanin has antibacterial and antioxidant effects at low concentrations, as wells as antifungal ones at high concentrations. Purpose: This study aimed to analyze the effects of Mauli banana stem extract at concentrations of 25%, 37.5%, and 50% on the quality of incised wound healing in male Rattus norvegicus rats by assessing FGF-2 expression and fibroblast concentration on days 3 and 7. Methods: This research represented an experimental laboratory-based investigation involving 32 rats of the Rattus norvegicus strain aged 2-2.5 months old. Sampling was performed using a simple random sampling technique since the research population was considered homogeneous and divided into 8 treatment groups (C3, M3-25, M3-37.5, M3-50, C7, M7-25, M7-37.5, M7-50). The rats in each group were anesthetized before their back was incised with length and width of 15x15mm with a depth of 2mm. Gel hydroxy propyl cellulose medium (HPMC) was applied to the incised wound of each rat in the control group, while stem Mauli banana extract was applied to that of each rat in the treatment groups three times a day at an interval of 6-8 hours. On day 3, four rats from each group were sacrificed, while, in the remaining groups, the same procedure was performed until day 7, at which point they (8 groups) were sacrificed for HE examination in order to assess the amount of fibroblast and for IHC examination to examine FGF-2 expression. Data regarding FGF-2 expression and the amount of fibroblast were analysed by means of One-way Anova and HSD. Results: The results showed that the Mauli banana stem extract could significantly improve the expression of FGF-2 and the amount of fibroblast cells compared to C3 and C7 groups. The highest increase in FGF-2 expression and fibroblast amount were found in all groups on days 3 and 7 treated with the Mauli banana stem extract at a concentration of 50%. Conclusion: There was an increase of FGF-2 expression and the amount of fibroblast cells in the incision wound healing process that induced with Mauli banana stem extract

    FGF-2 expression and the amount of fibroblast in the incised wounds of Rattus norvegicus rats induced with Mauli banana (Musa acuminata) stem extract

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    Background: Traditional wound treatment using herbal medicine is thought to maintain the health of families and society in general economically, effectively, and efficiently without inducing side effects. One genus of plant that can be used as a traditional medicine is the Mauli banana, indigenous to South Borneo. Mauli banana stem contains bioactive compounds, most of which are tannins along with ascorbic acid, saponin, β-carotene, flavonoids, lycopene, alkaloids, and flavonoids. Tanin has antibacterial and antioxidant effects at low concentrations, as wells as antifungal ones at high concentrations. Purpose: This study aimed to analyze the effects of Mauli banana stem extract at concentrations of 25%, 37.5%, and 50% on the quality of incised wound healing in male Rattus norvegicus rats by assessing FGF-2 expression and fibroblast concentration on days 3 and 7. Methods: This research represented an experimental laboratory-based investigation involving 32 rats of the Rattus norvegicus strain aged 2-2.5 months old. Sampling was performed using a simple random sampling technique since the research population was considered homogeneous and divided into 8 treatment groups (C3, M3-25, M3-37.5, M3-50, C7, M7-25, M7-37.5, M7-50). The rats in each group were anesthetized before their back was incised with length and width of 15x15mm with a depth of 2mm. Gel hydroxy propyl cellulose medium (HPMC) was applied to the incised wound of each rat in the control group, while stem Mauli banana extract was applied to that of each rat in the treatment groups three times a day at an interval of 6-8 hours. On day 3, four rats from each group were sacrificed, while, in the remaining groups, the same procedure was performed until day 7, at which point they (8 groups) were sacrificed for HE examination in order to assess the amount of fibroblast and for IHC examination to examine FGF-2 expression. Data regarding FGF-2 expression and the amount of fibroblast were analysed by means of One-way Anova and HSD. Results: The results showed that the Mauli banana stem extract could significantly improve the expression of FGF-2 and the amount of fibroblast cells compared to C3 and C7 groups. The highest increase in FGF-2 expression and fibroblast amount were found in all groups on days 3 and 7 treated with the Mauli banana stem extract at a concentration of 50%. Conclusion: There was an increase of FGF-2 expression and the amount of fibroblast cells in the incision wound healing process that induced with Mauli banana stem extract

    Differences in Panoramic Mandibular Index value between male and female hypertension patients using panoramic radiography

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    Objectives: This study is aimed to analyze the panoramic mandibular index value in male and female hypertensive patients using panoramic radiography. Materials and Methods: This research is a comparative analytic research with a purposive sampling technique. The study sample was hypertensive patients at Ulin Hospital, Banjarmasin from March to May 2023. Results: The results showed that there was no statistically significant difference through statistical data on the panoramic mandibular index value between men (0.27 ± 0.07) and women (0.26 ± 0.09), The age group that experienced a decrease in mandibular cortical thickness was most in the age group ≥ 65 years (0.22 ± 0.06). Conclusion: It is known that there is no significant difference in the panoramic mandibular index value between women and men

    BMP-2, bone remodeling, IL-1β, Mangifera casturi (Kosterm.) and tooth extraction.

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    Latar Belakang : Tubuh memiliki respon terhadap benda asing, ketika sel dan jaringan tubuh mengalami diskontinuitas/kerusakan karena sesuatu hal maka tubuh akan merespon dengan memperbaiki jaringan. Tubuh setelah mengalami jejas dan inflamasi akan melakukan proses resolusi dengan membuang eksudat dan jaringan yang mati dengan cara fagositosis dan ensimatik. Penyembuhan luka merupakan suatu proses kompleks yang melibatkan interaksi yang terus menerus antara sel dengan sel dan antara sel dengan matriks yang terangkum dalam tiga fase yang saling tumpang tindih. Tiga fase mekanisme fase penyembuhan luka yang terjadi yaitu fase inflamasi (0-3 hari), fase proliferasi dan pembentukan jaringan kult (3-14 hari) dan fase remodeling. Indonesia kaya akan sumber bahan obat alam dan tradisional yang secara turun temurun telah digunakan sebagai ramuan obat tradisional luka. Pengobatan tradisional luka dengan tanaman obat diharapkan dapat dimanfaatkan masyarakarat demi menjaga kesehatan keluarga dan masyarakat secara murah, efektif dan efisien tanpa menimbulkan efek samping. Salah satu jenis tanaman yang dapat digunakan sebagai bahan obat tradisional, yaitu pisang mauli yang merupakan pisang khas daerah Kalimantan Selatan. Batang pisang mauli memiliki kandungan senyawa bioaktif terbanyak tanin, diikuti asam askorbat, saponin, β-karoten, flavonoid, likopen, alkaloid, flavonoid. Tanin bersifat antibakteri dan antioksidan pada konsentrasi rendah, dan berfungsi sebagai antijamur pada konsentrasi tinggi. Berdasarkan hal tersebut, peneliti bermaksud melakukan penelitian mengenai pemberian ekstrak batang pisang mauli terhadap ekspresi FGF-2 dan jumlah sel fibroblas pada proses penyembuhan luka insisi. Tujuan : Tujuan penelitian ini adalah untuk menganalisis pemberian ekstrak batang pisang mauli 25%, 37,5%, 50% terhadap peningkatan kualitas penyembuhan luka insisi, Membuktikan peningkatan ekspresi FGF-2 dan peningkatan jumlah sel fibroblas pada proses penyembuhan luka insisi pada tikus galur wistar jantan dengan pemberian ekstrak batang pisang mauli 25%, 37,5%, 50% pada hari ke-3 dan hari ke-7. Metode : Jenis penelitian yang dilakukan adalah eksperimental laboratorik (true experimental), penelitian ini menggunakan hewan coba Rattus norvegicus usia 2-2,5 bulan. Teknik pengambilan sampel dilakukan dengan cara random karena populasi pada penelitian ini dianggap homogen, maka cara sampling yang digunakan adalah simple random sampling. Hewan coba sesuai ciri populasi penelitian sejumlah 32 ekor dibagi menjadi 4 kelompok perlakuan dan dilakukan anastesi kemudian insisi pada punggung dengan panjang dan lebar 15x15mm dan kedalaman 2mm. Pada daerah insisi tersebut dilakukan aplikasi gel pada kelompok kontrol dan aplikasi ekstrak pada kelompok perlakuan dilakukan 3x1 Hari dengan interval 6-8 jam. Pada hari ke-3, 4 tikus dari tiap kelompok dikorbankan. Kemudian, pada kelompok perlakuan lainnya dilakukan aplikasi yang sama sampai hari ke-7 dan diambil jaringan untuk pemeriksaan HE untuk melihat jumlah sel fibroblast dan IHC untuk melihat ekspresi FGF-2. Hasil : Hasil penelitian yang telah dilakukan membuktikan bahwa pemberian gel ekstrak batang pisang mauli dapat meningkatkan secara bermakna terhadap ekspresi FGF-2 dan jumlah sel fibroblast dibandingkan dengan kelompok kontrol. Konsentrasi 50% ekstrak batang pisang mauli yang paling banyak meningkatkan ekspresi FGF-2 dan jumlah sel fibroblast, karena secara keseluruhan ekstrak batang pisang mauli mengandung antioksidan sehingga mempunyai efek sebagai imunomodulator. Kesimpulan : Terjadi peningkatan ekspresi FGF-2 pada proses penyembuhan luka incisi pada tikus galur wistar jantan dengan pemberian ekstrak batang pisang mauli 25%, 37,5%, 50%. Terjadi peningkatan jumlah sel fibroblas pada proses penyembuhan luka incisi pada tikus galur wistar jantan dengan pemberian ekstrak batang pisang mauli 25%, 37,5%, 50%
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