18 research outputs found
Modulation of host cell processes by T3SS effectors
- Author
- A Arbeloa
- A Arbeloa
- A Arbeloa
- A Arbeloa
- A Hodgson
- A Mousnier
- A Patel
- AA Ajibade
- AD Whale
- AJ Ridley
- AM Keestra
- AR Wong
- AR Wong
- AS Halavaty
- AS Selyunin
- AS Selyunin
- AV Pilar
- B Kenny
- B Kenny
- B Kenny
- B Skaug
- B Wu
- BL Tang
- BU Klink
- C Giogha
- C Hemrajani
- C Hemrajani
- C Nadler
- CN Berger
- D Humphreys
- D Vingadassalom
- D Yan
- D Yan
- D Yang
- Danielle J. Ingle
- DW Lacher
- DY Lin
- E Martinez
- EA Miao
- EA Miao
- EL Hartland
- F Martin-Belmonte
- F Wan
- FK Chan
- FL Tomson
- FM Vega
- FR Blattner
- G Huys
- GX Song-Zhao
- H Drechsler
- H Drechsler
- H Piscatelli
- H Sason
- H Yen
- H Yen
- HJ Newton
- HM Ni
- HP Sham
- HW Moon
- I Vlisidou
- IR Vetter
- J Cherfils
- J Cui
- J Garmendia
- J Guignot
- J Kim
- J Yang
- JA Guttman
- JC Young
- JG Donaldson
- JL Bos
- John Bray
- JP Nougayrede
- JS Pearson
- JS Pearson
- JS Pearson
- JW Collins
- K Baruch
- K Reis
- K Smith
- K. Newton
- KG Campellone
- KG Campellone
- KG Jarvis
- KS Robinson
- L Goitre
- L Zhang
- LC Santy
- LF Nimri
- LG Glotfelty
- Li Zhang
- M Alipour
- M Batchelor
- M Cepeda-Molero
- M Kelly
- M Kim
- M Simovitch
- M Zhou
- MA Croxen
- MA Pallett
- MA Pallett
- ME Wickham
- MH Ruchaud-Sparagano
- MJ Brady
- MJ Eldridge
- MK Viljanen
- MM Turco
- MS Donnenberg
- MS Lee
- N Dong
- N Dong
- N Kayagaki
- N Kayagaki
- N Simpson
- NE Scott
- NK Petty
- NL Freeman
- NM Alto
- NM Alto
- O Marches
- O Marches
- O Marches
- P Broz
- P Cossart
- P Dean
- P Dean
- P Feng
- P Gurung
- P Madaule
- Q Yao
- R Bulgin
- R Caruso
- R Mundy
- RC Furniss
- RE Vance
- RK Gill
- RL Olsen
- RR Bulgin
- S Blasche
- S Etienne-Manneville
- S Gruenheid
- S Kailasan Vanaja
- S Knutton
- S Li
- S Muhlen
- S Nordlander
- S Qaidi El
- S Ruhl
- SJ Elliott
- SJ Heasman
- SK Vanaja
- SM Weiss
- SR Shames
- SR Shames
- SV Royan
- T Kawai
- T Matsuzawa
- T Morita-Ishihara
- T Song
- T Tobe
- TH Hazen
- TH Pham
- TH Pham
- TK McDaniel
- TM Long
- TS Agin
- VA Rathinam
- VF Crepin
- VF Crepin
- W Deng
- W Li
- X Chen
- X Gao
- X Gao
- X Gao
- X Tu
- Xiangpeng Sheng
- Y Litvak
- Y Wu
- Y Zhao
- Y Zhao
- Z Huang
- Z Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 30/08/2018
- Field of study
Two of the enteric Escherichia coli pathotypes-enteropathogenic E. coli (EPEC) and enterohaemorrhagic E. coli (EHEC)-have a conserved type 3 secretion system which is essential for virulence. The T3SS is used to translocate between 25 and 50 bacterial proteins directly into the host cytosol where they manipulate a variety of host cell processes to establish a successful infection. In this chapter, we discuss effectors from EPEC/EHEC in the context of the host proteins and processes that they target-the actin cytoskeleton, small guanosine triphosphatases and innate immune signalling pathways that regulate inflammation and cell death. Many of these translocated proteins have been extensively characterised, which has helped obtain insights into the mechanisms of pathogenesis of these bacteria and also understand the host pathways they target in more detail. With increasing knowledge of the positive and negative regulation of host signalling pathways by different effectors, a future challenge is to investigate how the specific effector repertoire of each strain cooperates over the course of an infection
Design, construction and operation of the ProtoDUNE-SP Liquid Argon TPC
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- Abi B
- Abud AA
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
- Ahmed J
- Alba JLB
- Ali-Mohammadzadeh B
- Alion T
- Allison K
- Almeida RMD
- Alonso MJR
- Alrashed M
- Alt C
- Alton A
- Amedo P
- Anderson J
- Andreopoulos C
- Andreotti M
- Andrews MP
- Andrianala F
- Andringa S
- Anfimov N
- Ankowski A
- Antoniassi M
- Antonova M
- Antoshkin A
- Antusch S
- Aranda-Fernandez A
- Ariga A
- Arnold LO
- Arroyave MA
- Asaadi J
- Asquith L
- Astiz ILDI
- Aurisano A
- Aushev V
- Autiero D
- Ayala-Torres M
- Azfar F
- B ACG
- Back A
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- Bagaturia I
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- Baldi P
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- Barros A
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- Barrow JL
- Basharina-Freshville A
- Bashyal A
- Basque V
- Battat JBR
- Battisti F
- Bay F
- Bazetto MCQ
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- Bechetoille E
- Behera B
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- Christensen A
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- Chukanov A
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- Terao K
- Ternes CA
- Terranova F
- Terrazas IC
- Testera G
- Thakore T
- Thea A
- Thompson JL
- Thorn C
- Timm SC
- Tishchenko V
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- Tonazzo A
- Torbunov D
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- Tsai Y
- Tsai YT
- Tsamalaidze Z
- Tsang KV
- Tsverava N
- Tufanli S
- Tull C
- Tyley E
- Tzanov M
- Uboldi L
- Uchida MA
- Urheim J
- Usher T
- Uzunyan S
- Vagins MR
- Vahle P
- Valdiviesso GA
- Valencia E
- Valentim R
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- Viren B
- Vrba T
- Wachala T
- Waldron AV
- Wallbank M
- Wallis C
- Wang H
- Wang J
- Wang L
- Wang MHLS
- Wang Y
- Wang Y
- Warburton K
- Warner D
- Wascko MO
- Water RGVD
- Waters D
- Watson A
- Weatherly P
- Weber A
- Weber M
- Wei H
- Weinstein A
- Wenman D
- Wetstein M
- White A
- Whitehead LH
- Whittington D
- Wilking MJ
- Wilkinson C
- Williams Z
- Wilson F
- Wilson RJ
- Wisniewski W
- Wolcott J
- Wongjirad T
- Wood A
- Wood K
- Worcester E
- Worcester M
- Wret C
- Wu W
- Wu W
- Xiao Y
- Xie F
- Yandel E
- Yang G
- Yang K
- Yang S
- Yang T
- Yankelevich A
- Yershov N
- Yonehara K
- Young T
- Yu B
- Yu H
- Yu H
- Yu J
- Yuan W
- Zaki R
- Zalesak J
- Zambelli L
- Zamorano B
- Zani A
- Zazueta L
- Zeller GP
- Zennamo J
- Zetina LMM
- Zeug K
- Zhang C
- Zhao M
- Zhivun E
- Zhu G
- Zilberman P
- Zimmerman ED
- Zito M
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- 'IOP Publishing'
- Publication date
- 04/08/2021
- Field of study
The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at the end of the H4 beamline. This detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment (DUNE), which will be constructed at the Sandford Underground Research Facility (SURF) in Lead, South Dakota, U.S.A. The ProtoDUNE-SP detector incorporates full-size components as designed for DUNE and has an active volume of 7 Ă 6 Ă 7.2 m3. The H4 beam delivers incident particles with well-measured momenta and high-purity particle identification. ProtoDUNE-SP's successful operation between 2018 and 2020 demonstrates the effectiveness of the single-phase far detector design. This paper describes the design, construction, assembly and operation of the detector components
Low exposure long-baseline neutrino oscillation sensitivity of the DUNE experiment
- Author
- Abi B
- Abud AA
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adams D
- Adinolfi M
- Aduszkiewicz A
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- Christodoulou G
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- Coelho JAB
- Collaboration DUNE
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- Hazen E
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- Holanda PCD
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- Horton-Smith GA
- Hostert M
- Hourlier A
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- Hronek MS
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- Thorn C
- Timm SC
- Tishchenko V
- Tomassetti L
- Tonazzo A
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- Torti M
- Tortola M
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- Publication date
- Field of study
The Deep Underground Neutrino Experiment (DUNE) will produce world-leading neutrino oscillation measurements over the lifetime of the experiment. In this work, we explore DUNE's sensitivity to observe charge-parity violation (CPV) in the neutrino sector, and to resolve the mass ordering, for exposures of up to 100 kiloton-megawatt-years (kt-MW-yr). The analysis includes detailed uncertainties on the flux prediction, the neutrino interaction model, and detector effects. We demonstrate that DUNE will be able to unambiguously resolve the neutrino mass ordering at a 3Ï (5Ï) level, with a 66 (100) kt-MW-yr far detector exposure, and has the ability to make strong statements at significantly shorter exposures depending on the true value of other oscillation parameters. We also show that DUNE has the potential to make a robust measurement of CPV at a 3Ï level with a 100 kt-MW-yr exposure for the maximally CP-violating values \delta_{\rm CP}} = \pm\pi/2. Additionally, the dependence of DUNE's sensitivity on the exposure taken in neutrino-enhanced and antineutrino-enhanced running is discussed. An equal fraction of exposure taken in each beam mode is found to be close to optimal when considered over the entire space of interest
Searching for solar KDAR with DUNE
- Author
- Abi B
- Abud AA
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
- Ahmed J
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- Alonso MJR
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- Andreopoulos C
- Andreotti M
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- Andringa S
- Anfimov N
- Ankowski A
- Antoniassi M
- Antonova M
- Antoshkin A
- Antusch S
- Aranda-Fernandez A
- Ariga A
- Arnold LO
- Arroyave MA
- Asaadi J
- Asquith L
- Astiz ILDI
- Aurisano A
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- B. ACG
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- Back JJ
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- Wang Y
- Warburton K
- Warner D
- Wascko MO
- Waters D
- Watson A
- Weatherly P
- Weber A
- Weber M
- Wei H
- Weinstein A
- Wenman D
- Wetstein M
- White A
- Whitehead LH
- Whittington D
- Wilking MJ
- Wilkinson C
- Williams Z
- Wilson F
- Wilson RJ
- Wisniewski W
- Wolcott J
- Wongjirad T
- Wood A
- Wood K
- Worcester E
- Worcester M
- Wret C
- Wu W
- Wu W
- Xiao Y
- Xie F
- Yandel E
- Yang G
- Yang K
- Yang S
- Yang T
- Yankelevich A
- Yershov N
- Yonehara K
- Young T
- Yu B
- Yu H
- Yu H
- Yu J
- Yuan W
- Zaki R
- Zalesak J
- Zambelli L
- Zamorano B
- Zani A
- Zazueta L
- Zeller GP
- Zennamo J
- Zetina LMM
- Zeug K
- Zhang C
- Zhao M
- Zhivun E
- Zhu G
- Zilberman P
- Zimmerman ED
- Zito M
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- Publication date
- Field of study
Express Your LOV: An Engineered Flavoprotein as a Reporter for Protein Expression and Purification
- Author
- Andrew J. Roe
- AS Selyunin
- AS Selyunin
- BJ Feilmeier
- D Drew
- DO Daley
- FW Studier
- H Dortay
- HP Sorensen
- I Vizcaino-Caston
- J Christie
- Jayde A. Gawthorne
- JM Christie
- JM Christie
- John M. Christie
- K McLuskey
- Katherine S. H. Beckham
- L. Evan Reddick
- LE Reddick
- M Gabrielsen
- M Gabrielsen
- Mads Gabrielsen
- MW Davidson
- Neal M. Alto
- Robert W. Sobol
- S Chapman
- S Graslund
- S Newstead
- Snezhana N. Akpunarlieva
- T Drepper
- X Shu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ
- Author
- A Choy
- A Phalipon
- Andrey S. Selyunin
- AS Selyunin
- Bethany A. Weigele
- Daniel A. Plymire
- DJ Stumpo
- DT Shima
- F Shao
- FA Barr
- G Charron
- H Ashida
- J Michiels
- J Mounier
- J Pei
- J Soding
- James M. Ertelt
- JM Buysse
- KA Datsenko
- M Franco
- M Liu
- MJ Roth
- MP Kamps
- MU Shiloh
- N Dong
- Neal M. Alto
- Nikolay Burnaevskiy
- NL Kelleher
- NL Slagowski
- NM Alto
- O Steele-Mortimer
- PK Herman
- Q Sun
- RA Kahn
- S Maurer-Stroh
- S McLaughlin
- Sing Sing Way
- SK Sze
- SS Way
- Steven M. Patrie
- TA Farazi
- Thomas G. Fox
- VM Rivera
- Y Liu
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Legionella pneumophila LidA Affects Nucleotide Binding and Activity of the Host GTPase Rab1
- Author
- Allan BB
- Axe EL
- Beard M
- Berger KH
- Berger KH
- Brombacher E
- Burstein ES
- Centers for Disease Control and Prevention
- Coleman DE
- Conover GM
- Dorer MS
- Dumenil G
- Ensminger AW
- Gabay JE
- Goody RS
- Herrmann C
- Horwitz MA
- Horwitz MA
- Ingmundson A
- Kabcenell AK
- Kagan JC
- Kusner DJ
- Luo ZQ
- Machner MP
- Machner MP
- Muller MP
- Murata T
- Neunuebel MR
- Nuoffer C
- Plutner H
- Saarikangas J
- Schoebel S
- Selyunin AS
- Tan Y
- Tan Y
- Tilney LG
- Tisdale EJ
- Vergne I
- Weide T
- Wiater LA
- Wilson BS
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Engineering an AB5 Protein Carrier
- Author
- A Loregian
- AL Horstman
- AS Selyunin
- B Mudrak
- C Chen
- C Rodighiero
- CM Ferencz
- CP Guimaraes
- D Liu
- DB Thompson
- F Akker van den
- FW Studier
- HAD Lagassé
- HK Shete
- J McKenzie
- J Schindelin
- JD PĂ©delacq
- JH Ryou
- JK Tinker
- JK Tinker
- JM Kim
- JW Craft
- JW Seale
- K Teter
- L Du
- MG Bexiga
- MG Jobling
- MG Jobling
- MT Bonde
- N Fornstedt
- N Zhang
- PI Bastiaens
- RG Zhang
- RL Guerrant
- S Liljeqvist
- S Mukhopadhyay
- SJ Hardy
- SJ Kaczmarczyk
- SJ Streatfield
- T Dinh
- TA Aguilera
- TM Allen
- WB Kauffman
- WI Lencer
- Y Feng
- Y Shai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Anisogamy evolved with a reduced sex-determining region in volvocine green algae
- Author
- AS Selyunin
- B Charlesworth
- D Bachtrog
- D Charlesworth
- DL Kirk
- ER Hanschen
- F Kasai
- G Bell
- H Kawai-Toyooka
- H Li
- H Lin
- H Nozaki
- H Nozaki
- H Nozaki
- H Nozaki
- JG Umen
- JJ Bull
- K Yamamoto
- KJ Hoff
- L Noe
- MD Herron
- MJ Misamore
- P Ferris
- PJ Ferris
- PJ Ferris
- PJ Ferris
- PJ Ferris
- PL Hoff De
- R Hiraide
- S Geng
- S Immler
- S Kato
- SE Prochnik
- SF Altschul
- SM Miller
- SS Merchant
- T Hamaji
- T Hamaji
- T Hamaji
- T Hamaji
- T Mori
- Y Hanzawa
- Z Fang
- Z Yang
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Inhibitors of the p21 Activated Kinases
- Author
- A Aboukameel
- A Begum
- A Goc
- A Pyronneau
- A Sicard
- AB Osman
- AS Azmi
- AS Azmi
- AS Karpov
- AS Selyunin
- B Song
- BC Nguyen
- BCQ Nguyen
- BJ Ryu
- BM Dolan
- BW Murray
- C Gao
- C Hao
- C Hao
- C Rane
- C Rane
- CC Ong
- CC Ong
- CO Ndubaku
- D Kesanakurti
- D Li
- D Yeo
- D Yeo
- DG Nguyen
- DS Williams
- GW Mak
- H Aoki
- H Chen
- H King
- H Maruta
- H Zhang
- HJ Zhang
- HY Baek
- HY Zhang
- J Chen
- J Gu
- J Maksimoska
- J Pozueta
- J Viaud
- J Zhang
- Jian Zhang
- JJ Crawford
- K Han
- K Huang
- L. S. Rosen
- LE Arias-Romero
- LE Wong
- LF He
- M Fulciniti
- M Sato
- MJ Kim
- MK Siu
- MKY Siu
- ML Hayashi
- N Huynh
- N Taira
- O Abu Aboud
- Q Guo
- QL Ma
- R Kaur
- R Kumar
- R Kumar
- RM Mohammad
- RX Liu
- S Cai
- S Chen
- S Jagadeeshan
- S Kalyaanamoorthy
- S Karthikeyan
- S Licciulli
- S Luo
- S Song
- S Takao
- SK McCarty
- SW Deacon
- SY Chen
- T Kamai
- VJ Hwang
- W Lee
- W Lu
- W McCoull
- W Yu
- X Gu
- X Li
- XR Shu
- Y Liu
- Y Wang
- Y Zhu
- Z Li
- ZP Fang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study