Efecto del método de insensibilización sobre los parámetros más importantes que influyen en el sacrificio y calidad de la carne de cerdo

The effect of captive bolt pistol (PP) and knocked down by hammer (NM) on sensibility and pork quality was evaluated employing 28 commercial porks considering as co-variables the ante mortem rest (REP), and environmental moisture (HUM) and temperature (TEMP) during sacrifice. PSE carcasses presence was higher (P<0.05) in NM. NM showed higher (P<0.01) presence of sensibility signs. No difference (P>0.05) was observed in the pH and TEMP at 45 min (pH45 and T45), nor at 24 h (pH24 and T24) post mortem in luminosity (L*), yellowness (b*) and drip loss (PG), probably because the muscles were already affected by the ante mortem handling. The pH24 showed a negative relationship (P<0.05) with REP and, when REP was superior to 43h, pH24 were characteristics of PSE carcasses. The increase in HUM and REP provoked higher (P<0.01) T24, where carcass cooling required more attention. The knocked down by hammer (NM) provoked a higher (P<0.01) redness and CRA by the accumulate stress during ante mortem handling and stunningCon la finalidad de evaluar el efecto de la pistola de perno cautivo (PP) y noqueo con mazo (NM) sobre la sensibilidad y calidad de la carne de cerdo, se utilizaron 28 cerdos comerciales y se consideró como covariables el reposo ante mortem (REP), humedad (HUM) y temperatura (TEMP) ambiente al momento del sacrificio. La presencia de canales PSE (pálida, suave y exudativa) fue mayor (P<0.05) en NM. El NM mostró mayor (P<0.01) presencia de signos de sensibilidad. No se observó diferencia (P>0.05) de pH y temperatura medidos a los 45 min (pH45 y T45), ni a las 24 h (pH24 y T24) post mortem en luminosidad (L*), tono amarillo (b*) y pérdida de agua por goteo (PG), probablemente porque la musculatura ya se encontraba afectada por las condiciones de manejo ante mortem. El pH24 presentó relación negativa (P<0.05) con REP y, cuando éste es mayor a 43 h, los valores de pH24 fueron característicos de canales PSE. El incremento de HUM y REP provocó mayor (P<0.01) T24, motivo por el cual el enfriamiento de la canal requiere de atención. El Noqueo con Mazo provocó mayor (P<0.01) intensidad del rojo (a*) y CRA, debido al estrés acumulado del manejo ante mortem y aturdimiento

Measurement, monitoring and knowledge of blood pressure: May Measurement Month, Colombia 2017

To describe the findings of implementing May Measurement Month 2017 in the adult Colom-bian population to raise awareness of the importance of blood pressure measuring, monitoring,and [email protected]

Measurement, monitoring and knowledge of blood pressure: May Measurement Month, Colombia 2017

To describe the findings of implementing May Measurement Month 2017 in the adult Colom-bian population to raise awareness of the importance of blood pressure measuring, monitoring,and awareness

Volcanes de Fango del Golfo de Cádiz. Areas de Estudio del proyecto LIFE+ INDEMARES

Fundación BiodiversidadPostprin

Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Agencia Española del Medicamento; Consejería de Salud de Andalucía.Background & Aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into the Spanish DILI Registry over a 20-year time period. Methods: Cases were identified, diagnosed and followed prospectively. Clinical features, drug information and outcome data were collected. Results: A total of 843 patients, with a mean age of 54 years (48% females), were enrolled up to 2018. Hepatocellular injury was associated with younger age (adjusted odds ratio [aOR] per year 0.983; 95% CI 0.974-0.991) and lower platelet count (aOR per unit 0.996; 95% CI 0.994-0.998). Anti-infectives were the most common causative drug class (40%). Liver-related mortality was more frequent in patients with hepatocellular damage aged ≥65 years (p = 0.0083) and in patients with underlying liver disease (p = 0.0221). Independent predictors of liver-related death/transplantation included nR-based hepatocellular injury, female sex, higher onset aspartate aminotransferase (AST) and bilirubin values. nR-based hepatocellular injury was not associated with 6-month overall mortality, for which comorbidity burden played a more important role. The prognostic capacity of Hy's law varied between causative agents. Empirical therapy (corticosteroids, ursodeoxycholic acid and MARS) was prescribed to 20% of patients. Drug-induced autoimmune hepatitis patients (26 cases) were mainly females (62%) with hepatocellular damage (92%), who more frequently received immunosuppressive therapy (58%). Conclusions: AST elevation at onset is a strong predictor of poor outcome and should be routinely assessed in DILI evaluation. Mortality is higher in older patients with hepatocellular damage and patients with underlying hepatic conditions. The Spanish DILI Registry is a valuable tool in the identification of causative drugs, clinical signatures and prognostic risk factors in DILI and can aid physicians in DILI characterisation and management. Lay summary: Clinical information on drug-induced liver injury (DILI) collected from enrolled patients in the Spanish DILI Registry can guide physicians in the decision-making process. We have found that older patients with hepatocellular type liver injury and patients with additional liver conditions are at a higher risk of mortality. The type of liver injury, patient sex and analytical values of aspartate aminotransferase and total bilirubin can also help predict clinical outcomes