Joint topology optimization, power control and spectrum allocation for intra-vehicular multi-hop sensor networks using dandelion-encoded heuristics

In the last years the interest in multi-hop communications has gained momentum within the research community due to the challenging characteristics of the intra-vehicular radio environment and the stringent robustness imposed on critical sensors within the vehicle. As opposed to point-to-point network topologies, multi-hop networking allows for an enhanced communication reliability at the cost of an additional processing overhead. In this context this manuscript poses a novel bi-objective optimization problem aimed at jointly minimizing (1) the average Bit Error Rate (BER) of sensing nodes under a majority fusion rule at the central data collection unit; and (2) the mean delay experienced by packets forwarded by such nodes due to multi-hop networking, frequency channel switching time multiplexing at intermediate nodes. The formulated paradigm is shown to be computationally tractable via a combination of evolutionary meta-heuristic algorithms and Dandelion codes, the latter capable of representing tree-like structures like those modeling the multi-hop routing approach. Simulations are carried out for realistic values of intra-vehicular radio channels and co-channel interference due to nearby IEEE 802.11 signals. The obtained results are promising and pave the way towards assessing the practical performance of the proposed scheme in real setups

Preparation of decellularized three dimentional scaffolds as the model for tissue engineering and their functional assessments in vitro application of blastema tissue

Tissue engineering is based on three main factors including scaffolds, cells and growth factors. Natural scaffolds derived from decellularized tissues and organs have been successfully used in tissue engineering. Decellularization studies have shown that natural scaffolds which maintaine their main structure and properties could be a suitable tool for studying cellular behaviors and preparation of such scaffolds is an important part of future research in biology that may have extensive applications in regenerative medicine and tissue engineering. Blastema tissue which is produced after injuries in some organisms has embryonic cell characteristics, and can be a suitable model for evaluation of cell behaviors in various tissues. In this review, the process of decellularization, process involved in preparation of 3D scaffolds derived from extracellular matrix of various tissues including cartilage, bone, gingiva, aorta and bladder, and assessment of their interactions with blastema tissue under in vitro conditions are discussed.   Keywords: Tissue engineering, Blastema tissue, Regenerative.

Preparation of decellularized three dimentional scaffolds as the model for tissue engineering and their functional assessments in vitro application of blastema tissue

Tissue engineering is based on three main factors including scaffolds, cells and growth factors. Natural scaffolds derived from decellularized tissues and organs have been successfully used in tissue engineering. Decellularization studies have shown that natural scaffolds which maintaine their main structure and properties could be a suitable tool for studying cellular behaviors and preparation of such scaffolds is an important part of future research in biology that may have extensive applications in regenerative medicine and tissue engineering. Blastema tissue which is produced after injuries in some organisms has embryonic cell characteristics, and can be a suitable model for evaluation of cell behaviors in various tissues. In this review, the process of decellularization, process involved in preparation of 3D scaffolds derived from extracellular matrix of various tissues including cartilage, bone, gingiva, aorta and bladder, and assessment of their interactions with blastema tissue under in vitro conditions are discussed

Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration

Purpose: To describe and quantify Bruch’s membrane (BM) and retinal pigment epithelium (RPE) separation using spectral-domain (SD) optical coherence tomography (OCT) in patients affected by inherited macular degenerations associated with BM thickening. Methods: Patients with molecularly confirmed Sorsby fundus dystrophy (SFD), dominant drusen (DD), and late-onset retinal degeneration (L-ORD) were included in this retrospective study. Each disease was classed as early stage if subjects were asymptomatic, intermediate stage if they had nyctalopia alone, and late stage if they described loss of central vision. The main outcome was measurement of BM-RPE separation on SD-OCT. The BM-RPE separation measurements were compared against those in normal age-matched controls. Results: Seventeen patients with SFD, 22 with DD, and eight with L-ORD were included. BM-RPE separation on SD-OCT demonstrated a high test-retest and interobserver reproducibility (intraclass correlation coefficients >0.9). BM-RPE separation was not identified in normal subjects. In SFD, there was greater BM-RPE separation in late-stage disease compared with intermediate-stage patients both at subfoveal (P < 0.05) and juxtafoveal (P < 0.01) locations. In DD, there was increased BM-RPE separation in late-stage disease compared with early stage at subfoveal (P < 0.001) and juxtafoveal (P < 0.05) topographies. There was no significant difference in BM-RPE separation between disease stages in L-ORD. Conclusions: BM-RPE separation is a novel, quantifiable phenotype in the three monogenic macular dystrophies studied, and may be an optical correlate of the histopathological thickening in BM that is known to occur. BM-RPE separation, as measured by OCT, varies with stage of disease in SFD and DD, but not in L-ORD. Translational Relevance : SFD, DD, and L-ORD are associated with BM thickening. In this group of patients, OCT assessment of macular structure identifies a separation of the usually single, hyperreflective line thought to represent BM and the overlying RPE. This separation is a novel and quantifiable feature of disease staging in SFD and DD