Gugatan Sederhana Dalam Proses Beracara

This study aims to find out the rules that were changed in the Supreme Court Regulation Number 2 of 2015 after the issuance of the Supreme Court Regulation Number 4 of 2019 concerning Procedures for Settlement of Simple Lawsuits and to find out the process of proceedings for simple lawsuits based on Supreme Court Regulation Number 4 of 2019 concerning Simple Lawsuit Settlement Procedures. This research uses normative legal research, using a research approach, namely the statute approach or juridical approach. Research results in The legal substance that was amended in Perma Number 2 of 2015 After the issuance of Perma Number 4 of 2019 concerning Procedures for Settlement of Simple Lawsuits, such as the amount of the value of the material lawsuit, the domicile of the defendant, regarding the use of electronic administration, regarding the presence of the parties in the trial, regarding the placement confiscation of guarantees, concerning claims which were acknowledged and refuted by the defendants, concerning decisions which were not objected to and concerning the determination of security (execution)

Tracing the Rules of Sexual Abnormality in the Islamic Jurisprudence

Sexual abnormality or deviation is a social disorder that is considered a violation of social norms and expectations of civility. Such behavior is deemed deviant because it goes against religious rules and values upheld by society. This research aims to establish a middle ground between sexual deviation and Islamic jurisprudence with regard to sexual deviation activities. To achieve this, a comprehensive review of linked data sources was conducted using qualitative and literary research. The findings showed that certain types of sexual deviance such as sadomasochism, exhibitionism, voyeurism, fetishes, and others have not been extensively discussed in fiqh books. According to the rules of Uşul Fiqh, "al-wasāil laha hukmu al-gāyah ", indicates that the law of means (instruments) follows the law of purpose. This shows sexual deviance is considered one of the means to adultery, and as such, it falls under the law of adultery.Sexual abnormality or deviation is a social disorder that is considered a violation of social norms and expectations of civility. Such behavior is deemed deviant because it goes against religious rules and values upheld by society. This research aims to establish a middle ground between sexual deviation and Islamic jurisprudence with regard to sexual deviation activities. To achieve this, a comprehensive review of linked data sources was conducted using qualitative and literary research. The findings showed that certain types of sexual deviance such as sadomasochism, exhibitionism, voyeurism, fetishes, and others have not been extensively discussed in fiqh books. According to the rules of Uşul Fiqh, "al-wasāil laha hukmu al-gāyah ", indicates that the law of means (instruments) follows the law of purpose. This shows sexual deviance is considered one of the means to adultery, and as such, it falls under the law of adultery

Aplikasi Pencarian Pondok Pesantren Terdekat Menggunakan Algoritma Haversine di Daerah Istimewa Yogyakarta

After the enactment of Law Number 18 of 2019 concerning Islamic Boarding Schools, now Islamic boarding schools have officially become one of the educational institutions that are recognized for their diplomas, as are other levels of education in general. This makes it a special attraction for people who want their children to get the best education based on religion at Islamic boarding schools, especially in the Special Region of Yogyakarta which is one of the cities of education in Indonesia. Based on the data directory of Islamic boarding schools in 2021/2022 owned by the Indonesian Ministry of Religion, there are 319 Islamic boarding schools in the Yogyakarta Region. With this number of Islamic boarding schools, there are still many Islamic boarding schools whose information is not known which makes it difficult for people to get information from these pesantren. Therefore, the author wants to build an android-based application system that can make it easier for people when they want to find information and the location of Islamic boarding schools with the closest routes around them. The author uses the Kotlin programming language to build Android applications, the method used in finding the nearest route and location uses the Haversine Algorithm formula, the Mapbox API is used to determine the route or line traffic, and the testing method uses Black-Box testing. This application will be useful as a medium that can provide information about Islamic boarding schools with the closest route in the special area of Yogyakarta so that the existence of Islamic boarding schools will be known more widely. &nbsp

SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection

Post-acute cardiac sequelae, following SARS-CoV-2 infection, are well recognized as complications of COVID-19. We have previously shown the persistence of autoantibodies against antigens in skin, muscle, and heart in individuals following severe COVID-19; the most common staining on skin tissue displayed an inter-cellular cement pattern consistent with antibodies against desmosomal proteins. Desmosomes play a critical role in maintaining the structural integrity of tissues. For this reason, we analyzed desmosomal protein levels and the presence of anti-desmoglein (DSG) 1, 2, and 3 antibodies in acute and convalescent sera from patients with COVID-19 of differing clinical severity. We find increased levels of DSG2 protein in sera from acute COVID-19 patients. Furthermore, we find that DSG2 autoantibody levels are increased significantly in convalescent sera following severe COVID-19 but not in hospitalized patients recovering from influenza infection or healthy controls. Levels of autoantibody in sera from patients with severe COVID-19 were comparable to levels in patients with non-COVID-19-associated cardiac disease, potentially identifying DSG2 autoantibodies as a novel biomarker for cardiac damage. To determine if there was any association between severe COVID-19 and DSG2, we stained post-mortem cardiac tissue from patients who died from COVID-19 infection. This confirmed DSG2 protein within the intercalated discs and disruption of the intercalated disc between cardiomyocytes in patients who died from COVID-19. Our results reveal the potential for DSG2 protein and autoimmunity to DSG2 to contribute to unexpected pathologies associated with COVID-19 infection

Analysis of vaginal microbicide film hydration kinetics by quantitative imaging refractometry

We have developed a quantitative imaging refractometry technique, based on holographic phase microscopy, as a tool for investigating microscopic structural changes in water-soluble polymeric materials. Here we apply the approach to analyze the structural degradation of vaginal topical microbicide films due to water uptake. We implemented transmission imaging of 1-mm diameter film samples loaded into a flow chamber with a 1.5×2 mm field of view. After water was flooded into the chamber, interference images were captured and analyzed to obtain high resolution maps of the local refractive index and subsequently the volume fraction and mass density of film material at each spatial location. Here, we compare the hydration dynamics of a panel of films with varying thicknesses and polymer compositions, demonstrating that quantitative imaging refractometry can be an effective tool for evaluating and characterizing the performance of candidate microbicide film designs for anti-HIV drug delivery. © 2014 Rinehart et al

Development of a synoptic MRI report for primary rectal cancer

<p>Abstract</p> <p>Background</p> <p>Although magnetic resonance imaging (MRI) is an important imaging modality for pre-operative staging and surgical planning of rectal cancer, to date there has been little investigation on the completeness and overall quality of MRI reports. This is important because optimal patient care depends on the quality of the MRI report and clear communication of these reports to treating physicians. Previous work has shown that the use of synoptic pathology reports improves the quality of pathology reports and communication between physicians.</p> <p>Methods</p> <p>The aims of this project are to develop a synoptic MRI report for rectal cancer and determine the enablers and barriers toward the implementation of a synoptic MRI report for rectal cancer in the clinical setting. A three-step Delphi process with an expert panel will extract the key criteria for the MRI report to guide pre-operative chemoradiation and surgical planning following a review of the literature, and a synoptic template will be developed. Furthermore, standardized qualitative research methods will be used to conduct interviews with radiologists to determine the enablers and barriers to the implementation and sustainability of the synoptic MRI report in the clinic setting.</p> <p>Conclusion</p> <p>Synoptic MRI reports for rectal cancer are currently not used in North America and may improve the overall quality of MRI report and communication between physicians. This may, in turn, lead to improved patient care and outcomes for rectal cancer patients.</p

Measuring adherence by visual inspection of returned empty gel applicators in the CAPRISA 004 microbicide trial.

CAPRISA, 2014.Abstract not available in pdf

Simultaneous in-field boost for patients with 1 to 4 brain metastasis/es treated with volumetric modulated arc therapy: a prospective study on quality-of-life

<p>Abstract</p> <p>Purpose</p> <p>To assess treatment toxicity and patients' survival/quality of life (QoL) after volumetric modulated arc therapy (VMAT) with simultaneous in-field boost (SIB) for cancer patients with 1 - 4 brain metastases (BM) treated with or without surgery.</p> <p>Methods and Materials</p> <p>Between March and December 2010, 29 BM patients (total volume BM, < 40 cm³) aged < 80 years, KPS ≥ 70, RPA < III were included in this prospective trial. Whole brain VMAT (30 Gy) and a SIB to the BM (40 Gy) was delivered in 10 fraction. Mean age was 62.1 ± 8.5 years. Fifteen (51.7%) underwent surgery. KPS and MMSE were prospectively assessed. A self-assessed questionnaire was used to assess the QoL (EORTC QLQ-C30 with -BN20 module).</p> <p>Results</p> <p>As of April 2011 and after a mean FU of 5.4 ± 2.8 months, 14 (48.3%) patients died. The 6-month overall survival was 55.1%. Alopecia was only observed in 9 (31%) patients. In 3-month survivors, KPS was significantly (<it>p </it>= 0.01) decreased. MMSE score remained however stable (<it>p </it>= 0.33). Overall, QoL did decrease after VMAT. The mean QLQ-C30 global health status (<it>p </it>= 0.72) and emotional functional (<it>p </it>= 0.91) scores were decreased (low QoL). Physical (<it>p </it>= 0.05) and role functioning score (<it>p </it>= 0.01) were significantly worse and rapidly decreased during treatment. The majority of BN20 domains and single items worsened 3 months after VMAT except headaches (<it>p </it>= 0.046) and bladder control (<it>p </it>= 0.26) which improved.</p> <p>Conclusions</p> <p>The delivery of 40 Gy in 10 fractions to 1 - 4 BM using VMAT was achieved with no significant toxicity. QoL, performance status, but not MMSE, was however compromised 3 months after treatment in this selected cohort of BM patients.</p

SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

SPL7013 Gel (VivaGel®) is a microbicide in development for prevention of HIV and HSV. This clinical study assessed retention and duration of antiviral activity following vaginal administration of 3% SPL7013 Gel in healthy women. Participants received 5 single doses of product with ≥5 days between doses. A cervicovaginal fluid (CVF) sample was collected using a SoftCup™ pre-dose, and immediately, or 1, 3, 12 or 24 h post-dose. HIV-1 and HSV-2 antiviral activities of CVF samples were determined in cell culture assays. Antiviral activity in the presence of seminal plasma was also tested. Mass and concentration of SPL7013 in CVF samples was determined. Safety was assessed by reporting of adverse events. Statistical analysis was performed using the Wilcoxon signed-rank test with Bonferroni adjustment; p≤0.003 was significant. Eleven participants completed the study. Inhibition of HIV-1 and HSV-2 by pre-dose CVF samples was negligible. CVF samples obtained immediately after dosing almost completely inhibited (median, interquartile range) HIV-1 [96% (95,97)] and HSV-2 [86% (85,94)], and activity was maintained in all women at 3 h (HIV-1 [96% (95,98), p = 0.9]; HSV-2 [94% (91,97), p = 0.005]). At 24 h, >90% of initial HIV-1 and HSV-2 inhibition was maintained in 6/11 women. SPL7013 was recovered in CVF samples obtained at baseline (46% of 105 mg dose). At 3 and 24 h, 22 mg and 4 mg SPL7013, respectively, were recovered. More than 70% inhibition of HIV-1 and HSV-2 was observed if there was >0.5 mg SPL7013 in CVF samples. High levels of antiviral activity were retained in the presence of seminal plasma. VivaGel was well tolerated with no signs or symptoms of vaginal, vulvar or cervical irritation reported. Potent antiviral activity was observed against HIV-1 and HSV-2 immediately following vaginal administration of VivaGel, with activity maintained for at least 3 h post-dose. The data provide evidence of antiviral activity in a clinical setting, and suggest VivaGel could be administered up to 3 h before coitus

A Rapid Synthesis of Oriented Palladium Nanoparticles by UV Irradiation

Palladium nanoparticles of average size around 8 nm have been synthesized rapidly by UV irradiation of mixture of palladium chloride and potassium oxalate solutions. A rod-shaped palladium oxalate complex has been observed as an intermediate. In the absence of potassium oxalate, no Pd nanoparticles have been observed. The synthesized Pd nanoparticles have been characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), selective area electron diffraction and energy dispersive analysis by X-rays (EDAX) analyses. XRD analysis indicates the preferential orientation of catalytically active {111} planes in Pd nanoparticles. A plausible mechanism has been proposed for the formation of anisotropic Pd nanoparticles