A qualitative evaluation of the impact of a palliative care course on preregistration nursing students' practice in Cameroon

Background Current evidence suggests that palliative care education can improve preregistration nursing students’ competencies in palliative care. However, it is not known whether these competencies are translated into students’ practice in the care of patients who are approaching the end of life. This paper seeks to contribute to the palliative care evidence base by examining how nursing students in receipt of education report transfer of learning to practice, and what the barriers and facilitators may be, in a resource-poor country. Methods We utilised focus groups and individual critical incident interviews to explore nursing students’ palliative care learning transfer. Three focus groups, consisting of 23 participants and 10 individual critical incident interviews were conducted with preregistration nursing student who had attended a palliative care course in Cameroon and had experience caring for a patient approaching the end of life. Data was analysed thematically, using the framework approach. Results The results suggest that nursing students in receipt of palliative care education can transfer their learning to practice. Students reported recognizing patients with palliative care needs, providing patients with physical, psychosocial and spiritual support and communicating patient information to the wider care team. They did however perceive some barriers to this transfer which were either related to themselves, qualified nurses, the practice setting or family caregivers and patients. Conclusion The findings from this study suggest that nursing student in receipt of palliative care education can use their learning in practice to provide care to patients and their families approaching the end of life. Nevertheless, these findings need to be treated with some caution given the self-reported nature of the data. Demonstrating the link between preregistration palliative care education and patient care is vital to ensuring that newly acquired knowledge and skills are translated and embedded into clinical practice. This study also has implications for advocating for palliative care policies and adequately preparing clinical placement sites for students’ learning and transfer of learning

Antinociception induced by stimulating amygdaloid nuclei in rats: changes produced by systemically administered antagonists

The antinociceptive effects of stimulating the medial (ME) and central (CE) nuclei of the amygdala in rats were evaluated by the changes in the latency for the tail withdrawal reflex to noxious heating of the skin. A 30-s period of sine-wave stimulation of the ME or CE produced a significant and short increase in the duration of tail flick latency. A 15-s period of stimulation was ineffective. Repeated stimulation of these nuclei at 48-h intervals produced progressively smaller effects. The antinociception evoked from the ME was significantly reduced by the previous systemic administration of naloxone, methysergide, atropine, phenoxybenzamine, and propranolol, but not by mecamylamine, all given at the dose of 1.0 mg/kg. Previous systemic administration of naloxone, atropine, and propranolol, but not methysergide, phenoxybenzamine, or mecamylamine, was effective against the effects of stimulating the CE. We conclude that the antinociceptive effects of stimulating the ME involve at least opioid, serotonergic, adrenergic, and muscarinic cholinergic descending mechanisms. The effects of stimulating the CE involve at least opioid, ß-adrenergic, and muscarinic cholinergic descending mechanisms

Model-independent search for CP violation in D0 to K-K+pi-pi+ and D0 to pi-pi+pi+pi- decays

A search for CP violation in the phase-space structures of D0 and D0bar decays to the final states K-K+pi-pi+ and pi-pi+pi+pi- is presented. The search is carried out with a data set corresponding to an integrated luminosity of 1.0fb^-1 collected in 2011 by the LHCb experiment in $pp$ collisions at a centre-of-mass energy of 7TeV. For the K-K+pi-pi+ final state, the four-body phase space is divided into 32 bins, each bin with approximately 1800 decays. The p-value under the hypothesis of no CP violation is 9.1%, and in no bin is a CP asymmetry greater than 6.5% observed. The phase space of the pi-pi+pi+pi- final state is partitioned into 128 bins, each bin with approximately 2500 decays. The $p$-value under the hypothesis of no CP violation is 41%, and in no bin is a CP asymmetry greater than 5.5% observed. All results are consistent with the hypothesis of no CP violation at the current sensitivity

First measurement of time-dependent CP violation in Bs -> K+K- decays

Direct and mixing-induced CP-violating asymmetries in Bs -> K+K- decays are measured for the first time using a data sample of pp collisions, corresponding to an integrated luminosity of 1.0 fb^{-1}, collected with the LHCb detector at a centre-of-mass energy of 7 TeV. The results are C_{KK} = 0.14 \pm 0.11 \pm 0.03 and S_{KK} = 0.30 \pm 0.12 \pm 0.04, where the first uncertainties are statistical and the second systematic. The corresponding quantities are also determined for B0 -> pi+pi- decays to be C_{pipi} = -0.38 \pm 0.15 \pm 0.02 and S_{pipi} = -0.71 \pm 0.13 \pm 0.02, in good agreement with existing measurements

Measurement of the C¶C¶ asymmetry in B+→K+μ+μ−B^+ \rightarrow K^+ μ^+ μ^- decays

A measurement of the $C\P$ asymmetry in $B^+ \rightarrow K^+ \mu^+ \mu^-$ decays is presented using $pp$ collision data, corresponding to an integrated luminosity of 1.0${\,fb}^{-1}$, recorded by the LHCb experiment during 2011 at a centre-of-mass energy of 7 TeV. The measurement is performed in seven bins of $\mu^+ \mu^-$ invariant mass squared in the range ${0.0

Measurement of CP observables in B0 -> D K*0 with D -> K+ K-

The decay B0 -> D K*0 and the charge conjugate mode are studied using 1.0fb-1 of pp collision data collected by the LHCb experiment at sqrt(s) = 7TeV in 2011. The CP asymmetry between the B0 -> D K*0 and the B0bar -> D K*0bar decay rates, with the neutral D meson in the CP-even final state K+K-, is found to be A_d_KK = -0.45 +- 0.23 +- 0.02, where the first uncertainty is statistical and the second is systematic. In addition, favoured B0 -> D K*0 decays are reconstructed with the D meson in the non-CP eigenstate K+ pi-. The ratio of the B-flavour averaged decay rates in D decays to CP and non-CP eigenstates is measured to be R_d_KK = 1.36 (+0.37) (-0.32) +- 0.07, where the ratio of the branching fractions of D0 -> K- pi+ to D0 -> K+ K- decays is included as multiplicative factor. The CP asymmetries measured with two control channels, the favoured B0 -> DK*0 decay with D -> K+ pi- and the Bs0bar -> D K*0 decay with D K+ K-, are also reported

Measurement of the branching fractions of the decays Bs -> D0bar K- π+ and B0 -> D0bar K+ π-

The first observation of the decay Bs -> D0bar K- {\pi}+ is reported. The analysis is based on a data sample, corresponding to an integrated luminosity of 1.0 fb-1 of pp collisions, collected with the LHCb detector. The branching fraction relative to that of the topologically similar decay B0 -> D0bar {\pi}+ {\pi}- is measured to be BR(Bs -> D0bar K- {\pi}+)/BR(B0 -> D0bar {\pi}+ {\pi}-) = 1.18 +- 0.05 (stat.) +- 0.12 (syst.). In addition, the relative branching fraction of the decay B0 -> D0bar K+ {\pi}- is measured to be BR(B0 -> D0bar K+ {\pi}-)/BR(B0 -> D0bar {\pi}+ {\pi}-) = 0.106 +- 0.007 (stat.) +- 0.008 (syst.)