41 research outputs found

    Sales promotions and channel coordination

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    Consumer sales promotions are usually the result of the decisions of two marketing channel parties, the manufacturer and the retailer. In making these decisions, each party normally follows its own interest: i.e. maximizes its own profit. Unfortunately, this results in a suboptimal outcome for the channel as a whole. Independent profit maximization by channel parties leads to a lack of channel coordination with the implication of leaving money on the table. This may well contribute to the notoriously low profitability of sales promotions. This paper first shows analytically why the suboptimality occurs, and then presents an empirical demonstration, using a unique dataset from an Efficient Consumer Response (ECR) project; ECR is a movement in which parties work together to optimize the distribution channel). In this dataset, actual profit is only a small fraction of potential profit, implying that there is a large degree of suboptimality. It is important that (1) channel parties are aware of this suboptimality; and (2) that they have tools to deal with it. Solutions to the channel coordination problem should ensure that the goals of the individual channel parties are aligned with the goals of the channel as a whole. The paper proposes one particular agreement for this purpose, called proportional discount sharing. Application to the ECR data shows a win-win result for both the manufacturer and the retailer. Recognition of the channel coordination problem by the manufacturer and the retailer is the necessary starting point for agreeing on a way of solving it in a win-win fashion

    Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain

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    The Effectiveness of conservative management for acute Whiplash Associated Disorder (WAD) II : a systematic review and meta-analysis of randomised controlled trials

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    To evaluate the effectiveness of conservative management (except drug therapy) for acute Whiplash Associated Disorder (WAD) II.Systematic review and meta-analysis of Randomised Controlled Trials (RCTs) using a pre-defined protocol. Two independent reviewers searched information sources, decided eligibility of studies, and assessed risk of bias (RoB) of included trials. Data were extracted by one reviewer and checked by the other. A third reviewer mediated any disagreements throughout. Qualitative trial and RoB data were summarised descriptively. Quantitative syntheses were conducted across trials for comparable interventions, outcome measures and assessment points. Meta-analyses compared effect sizes with random effects, using STATA version 12.PEDro, Medline, Embase, AMED, CINAHL, PsycINFO, and Cochrane Library with manual searching in key journals, reference lists, British National Bibliography for Report Literature, Center for International Rehabilitation Research Information & Exchange, and National Technical Information Service were searched from inception to 15th April 2015. Active researchers in the field were contacted to determine relevant studies.RCTs evaluating acute (10 days) interventions, there were no statistically significant differences in all outcome measures between interventions at any time.Conservative and active interventions may be useful for pain reduction in patients with acute WADII. Additionally, cervical horizontal mobility could be improved by conservative intervention. The employment of a behavioural intervention (e.g. act-as-usual, education and self-care including regularly exercise) could have benefits for pain reduction and improvement in cervical movement in the coronal and horizontal planes. The evidence was evaluated as low/very low level according to the Grading of Recommendations Assessment, Development and Evaluation system

    Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

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    Pollution of the river Rhine by the accident at Sandoz Ag

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    Op basis van de door DBW/RIZA en het RIVM uitgevoerde metingen van de concentraties in Rijnwater van de bij Bazel geloosde bestrijdingsmiddelen zijn schattingen gemaakt van de maximale concentraties van deze stoffen in de Nederlandse oppervlaktewateren. Het betrof met name de stoffen disulfoton en thiometon met maximum concentraties bij Lobith van 2-3 ug/l resp. 8-9 ug/l. In samenhang met de toxiciteitsgegevens moet geconcludeerd worden dat voor de Nederlandse ecosystemen geen schade van dit incident op lange termijn te verwachten is. Overigens is door het ontbreken van inzicht in de exacte toestand van de huidige ecosystemen voor het ongeval herstel van het ecosysteem moeilijk te verifieren. Aanbevolen wordt een biomonitoringsysteem te ontwikkelen zodat bij eventuele toekomstige gevallen de ecologische betekenis beter kan worden aangegeven. De gifgolf kan leiden tot een zekere verslechtering van de kwaliteit van het uit oeverinfiltraat gewonnen drinkwater.HIHM
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