Plasma Carcinoembyonic Antigen (CEA) levels in Nigerian with breast cancer

Nigerian Quarterly Journal of Hospital Medicine Vol.10(1) 2000: 41-4

Bacteraemia and acute phase proteins in Nigerian women with spontaneous recurrent abortion

C-reactive protein, alpha–2-macroglobulin, transferrin and bacteraemia were studied in women with recurrent abortion and compared with the pregnant women as well as non-pregnant women with no history of abortion (controls). The results showed a significantly reduced level of transferrin but significantly raised levels of alpha-2-macroglobulin and C-reactive protein in the pregnant women with recurrent abortion (P+R) compared with pregnant women without recurrent abortion (P-R) or the controls. Four genera of bacteria (Staphylococcus aureus, Streptococcus agalactiae, Klebsiella species and Clostridium perfringes) were isolated from the blood of women with recurrent abortion while there were 2 genera of bacteria (S. aureus and Strept. Agalactiae) were isolated from the blood of pregnant women without recurrent abortion. This study had shown that inflammation and bacterial infection contribute to spontaneous recurrent abortion. African Journal of Clinical and Experimental Microbiology Vol. 6 (3) 2005: 203-20

Relationship Between Oxidative Stress and Preeclampsia in Nigerian Women

Introduction: Oxidative stress contributes to the pathogenesis of many disease states including preeclampsia. However the degree of change and the precise timing of the tilt from balanced to oxidative stress is not well document in preeclamptic toxaemia of pregnancy in Nigerian women. Thisunderlined the basis of this studyMaterial and Method: 580 nulliparous attendees who consented to the study were enrolled from July 2006 to February 2009. A structured questionnaire was utilized for one aspect of the study while 5ml ofwhole blood sample was obtained at booking and from 29, 25, 21and 25 pregnant women who developed preeclampsia, pregnant women without hypertension, women sampled at post natal visit and non pregnant women of similar age respectively, for determination of total antioxidant status.Results: The incidence of hypertension in the study was 19% while the incidence of preeclampsia was 5%. The study showed progressive consumption total oxidative capacity with progression in pregnancyas evidenced by significant decrease in the mean TAS of the women that delivered with preeclampsia (35% decrease) and without hypertension(19% decrease) compared to TAS level at booking p=0.000, 0.035 respectively.Conclusion: Our study has buttressed the growing body of evidence supporting increased oxidative stress in the pathogenesis of preeclampsia.Key Words: Preeclampsia, oxidative stress, total antioxidant statu