67 research outputs found
The value of immunohistochemical research on PCNA, p53 and heat shock proteins in prostate cancer management: a review.
This review addresses the significance of the expression of proliferating cell nuclear antigen (PCNA), p53 and some heat shock proteins (Hsps) in prostate carcinoma (PC). In fact, PCNA and p53 are two widely discussed tools in PC diagno- sis, mainly because of the controversy regarding the signifi- cance of their expression during prostate cancer development and progression. At the same time, only few studies have shown the potential role of Hsps in carcinogenesis and their overexpression in pre-neoplastic and neoplastic lesions of the prostate. We briefly describe the physiological roles of Hsps in normal cells, and the significance of their immunohistochem- ical detection in PC as well as in pre-cancerous lesions of the prostate. We will also discuss the possible functional interac- tions of these molecules in both dysplastic and neoplastic cell
Helicobacter pylori and EpsteinâBarr Virus Co-Infection in Gastric Disease: What Is the Correlation with p53 Mutation, Genes Methylation and Microsatellite Instability in a Cohort of Sicilian Population?
Genetic predisposition, environmental factors, and infectious agents interact in the development of gastric diseases. Helicobacter pylori (Hp) and EpsteinâBarr virus (EBV) infection has
recently been shown to be correlated with these diseases. A cross-sectional study was performed on
100 hospitalized Italian patients with and without gastric diseases. The patients were stratified into
four groups. Significant methylation status differences among CDH1, DAPK, COX2, hMLH1 and
CDKN2A were observed for coinfected (Hp-EBV group) patients; particularly, a significant presence
of COX2 (p = 0.0179) was observed. For microsatellite instability, minor stability was described in
the Hp-HBV group (69.23%, p = 0.0456). Finally, for p53 mutation in the EBV group, exon 6 was,
significantly, most frequent in comparison to others (p = 0.0124), and in the Hp-EBV group exon
8 was, significantly, most frequent in comparison to others (p < 0.0001). A significant positive relationship was found between patients with infection (Hp, EBV or both) and p53 mutation (rho = 0.383,
p = 0.0001), methylation status (rho = 0.432, p < 0.0001) and microsatellite instability (rho = 0.285, p =
0.004). Finally, we observed among infection and methylation status, microsatellite instability, and
p53 mutation a significant positive relationship only between infection and methylation status (OR =
3.78, p = 0.0075) and infection and p53 mutation (OR = 6.21, p = 0.0082). According to our analysis,
gastric disease in the Sicilian population has different pathways depending on the presence of various
factors, including infectious agents such as Hp and EBV and genetic factors of the subject
Therapeutic Options for the Treatment of Actinic Keratosis with Scalp and Face Localization
Actinic keratosis (AK) is a common skin disease related
to ultraviolet chronic exposure, that is now considered a
squamous cell carcinoma in situ. Primary skin cancer prevention
strategies should be recommended for high risk patients. There
is a wide spectrum of treatment options available for AKs, and
several variables should be taken into account regarding the best
therapeutic choice for each patient. The purpose of this article is
to review the current treatment strategies for AKs localized on
the face and scalp, with a focus on the practical point of view that
could be useful for choosing the best therapeutic option. The two
main therapeutic approaches will be distinguished first: lesiondirected
and field-directed. Afterwards, the treatment based on
clinical type and patient comorbidity will be discussed
Face and scalp basal cell carcinoma treatment: A review of the literature
Basal cell carcinoma (BCC) is the most frequent skin cancer and is characterized by slow growth, even if it can be locally invasive and rarely metastasizes. Many different phenotypic presentations and histopathologic subtypes have been described, and the current guidelines subdivide BCCs into low-risk (nodular and superficial) and high-risk subtypes (micronodular, infiltrating, and morphoeic BCC and those with squamous differentiation). Dermoscopy allows the identification of the features associated with these different subtypes. Compared with the low-risk forms of BCC, more aggressive ones tend to undergo more frequently incomplete surgical excision and perineural invasion, so the identification of these lesions before surgery is extremely important. The gold standard of treatment is surgery, particularly for the H region of the face and infiltrative lesions, but other options are available and selected according to many variables, including body area, age, comorbidities, and clinical, dermoscopic, and histopathological features of the lesion. Moreover, the possible complications of surgical approaches, namely healing defects, failure of skin grafts, and wound infection, should be considered. In this review we discuss the management of BCC localized on the face and scalp, according to the currently available treatment options. </p
Therapeutic Options for the Treatment of Actinic Keratosis with Scalp and Face Localization
Actinic keratosis (AK) is a common skin disease related
to ultraviolet chronic exposure, that is now considered a
squamous cell carcinoma in situ. Primary skin cancer prevention
strategies should be recommended for high risk patients. There
is a wide spectrum of treatment options available for AKs, and
several variables should be taken into account regarding the best
therapeutic choice for each patient. The purpose of this article is
to review the current treatment strategies for AKs localized on
the face and scalp, with a focus on the practical point of view that
could be useful for choosing the best therapeutic option. The two
main therapeutic approaches will be distinguished first: lesiondirected
and field-directed. Afterwards, the treatment based on
clinical type and patient comorbidity will be discussed
Therapeutic Options for the Treatment of Actinic Keratosis with Scalp and Face Localization
Actinic keratosis (AK) is a common skin disease related to ultraviolet chronic exposure, that is now considered a
squamous cell carcinoma in situ. Primary skin cancer prevention
strategies should be recommended for high risk patients. There
is a wide spectrum of treatment options available for AKs, and
several variables should be taken into account regarding the best
therapeutic choice for each patient. The purpose of this article is
to review the current treatment strategies for AKs localized on
the face and scalp, with a focus on the practical point of view that
could be useful for choosing the best therapeutic option. The two
main therapeutic approaches will be distinguished first: lesiondirected and field-directed. Afterwards, the treatment based on
clinical type and patient comorbidity will be discussed
Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury
Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion
Effects of initial-state dynamics on collective flow within a coupled transport and viscous hydrodynamic approach
We evaluate the effects of preequilibrium dynamics on observables in
ultrarelativistic heavy-ion collisions. We simulate the initial nonequilibrium
phase within A MultiPhase Transport (AMPT) model, while the subsequent
near-equilibrium evolution is modeled using (2+1)-dimensional relativistic
viscous hydrodynamics. We match the two stages of evolution carefully by
calculating the full energy-momentum tensor from AMPT and using it as input for
the hydrodynamic evolution. We find that when the preequilibrium evolution is
taken into account, final-state observables are insensitive to the switching
time from AMPT to hydrodynamics. Unlike some earlier treatments of
preequilibrium dynamics, we do not find the initial shear viscous tensor to be
large. With a shear viscosity to entropy density ratio of , our model
describes quantitatively a large set of experimental data on Pb+Pb collisions
at the Large Hadron Collider(LHC) over a wide range of centrality: differential
anisotropic flow , event-plane correlations, correlation
between and , and cumulant ratio .Comment: 10 pages, v2: minor revisio
DI ALCUNI PRODROMI ED EFFETTI DEL PICTORIAL TURN
Il testo della relazione analizza alcuni aspetti della teoria di W.J.T. Mitchell in riferimento allo stato attuale dei Visual Studies
- âŠ