INTERCORRÊNCIAS EM TOXINA BOTULÍNICA

Esta revisão bibliográfica aborda as intercorrências no uso da toxina botulínica em procedimentos estéticos. Foram analisadas referências científicas, incluindo estudos clínicos, revisões sistemáticas e meta-análises. As principais complicações relatadas foram ptose palpebral, assimetria facial, efeitos indesejados no sorriso, dor no local da injeção, equimose e edema. Apesar disso, as intercorrências são geralmente de baixa incidência, leves e transitórias. A revisão ressalta a importância do conhecimento e da experiência do profissional de saúde na prevenção e no manejo adequado dessas complicações. A toxina botulínica continua sendo considerada um tratamento seguro e eficaz quando administrada corretamente.This bibliographical review approaches complications in the use of botulinum toxin in aesthetic procedures. Scientific references were analyzed, including clinical studies, systematic reviews and meta-analyses. The main complications reported were eyelid ptosis, facial asymmetry, unwanted effects on the smile, pain at the injection site, ecchymosis and edema. Despite this, complications are generally of low incidence, mild and transient. The review emphasizes the importance of the health professional's knowledge and experience in the prevention and proper management of these complications. Botulinum toxin continues to be considered a safe and effective treatment when administered correctly.  Esta revisión de la literatura aborda las complicacionesen el uso de la toxina botulínica en procedimientos estéticos. Se analizaron referencias científicas, incluidos estudiosclínicos, revisiones sistemáticas y metanálisis. Las principalescomplicaciones reportadas fueron ptosis palpebral, asimetríafacial, efectos no deseados en la sonrisa, dolor en el lugar de la inyección, hematomas y edema. A pesar de ello, lascomplicaciones son generalmente de baja incidencia, leves y transitorias. La revisión destaca la importancia delconocimiento y la experiencia de los profesionales sanitariospara prevenir y gestionar adecuadamente estas complicaciones. La toxina botulínica sigue considerándose untratamiento seguro y eficaz cuando se administra correctamente.  Esta revisão bibliográfica aborda as intercorrências no uso da toxina botulínica em procedimentos estéticos. Foram analisadas referências científicas, incluindo estudos clínicos, revisões sistemáticas e meta-análises. As principais complicações relatadas foram ptose palpebral, assimetria facial, efeitos indesejados no sorriso, dor no local da injeção, equimose e edema. Apesar disso, as intercorrências são geralmente de baixa incidência, leves e transitórias. A revisão ressalta a importância do conhecimento e da experiência do profissional de saúde na prevenção e no manejo adequado dessas complicações. A toxina botulínica continua sendo considerada um tratamento seguro e eficaz quando administrada corretamente

Oxido-and dioxido-vanadium(V) complexes supported on carbon materials: Reusable catalysts for the oxidation of cyclohexane

UIDB/00100/2020 UIDB/50006/2020 UIDP/50006/2020 CEECINST/00102/2018 UIDB/50020/2020 IST-ID/102/2018 UID/QUI/00100/2019-BL/CQE-2017-022 FCTOxidovanadium(V) and dioxidovanadium(V) compounds, [VO(OEt)L] (1) and [Et3NH][VO2L] (2), were synthesized using an aroylhydrazone Schiff base (5-bromo-2-hydroxybenzylidene)-2-hydroxybenzohydrazide (H2L). They were characterized by elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), (1H and51V) nuclear magnetic resonance (NMR), electrospray ioniza-tion mass spectrometry (ESI-MS) and single crystal X-ray diffraction analyses. Both complexes were immobilized on functionalized carbon nanotubes and activated carbon. The catalytic performances of 1 and 2, homogenous and anchored on the supports, were evaluated for the first time towards the MW-assisted peroxidative oxidation (with tert-butylhydroperoxide, TBHP) of cyclohexane under heterogeneous conditions. The immobilization of 1 and 2 on functionalized carbon materials improved the efficiency of catalytic oxidation and allowed the catalyst recyclability with a well-preserved catalytic activity.publishersversionpublishe

Hidden non-Fermi liquid behavior due to crystal field quartet

We study a realistic Kondo model for crystal field quartet ground states having magnetic and non-magnetic (quadrupolar) exchange couplings with conduction electrons, using the numerical renormalization group method. We focus on a local effect dependent on singlet excited states coupled to the quartet, which reduces the non-magnetic coupling significantly and drives non-Fermi liquid behavior observed in the calculated quadrupolar susceptibility. A crossover from the non-Fermi liquid state to the Fermi liquid state is characterized by a small energy scale very sensitive to the non-magnetic coupling. On the other hand, the Kondo temperature observed in the magnetic susceptibility is less sensitive. The different crystal-field dependence of the two exchange couplings may be related to the different $x$ dependence of quadrupolar and magnetic ordering temperatures in Ce$_x$La$_{1-x}$B$_6$.Comment: 7 pages, 5 EPS figures, REVTe

Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion

Background Ischemia and reperfusion (I/R) causes tissue damage and intracellular calcium levels are a factor of cell death. Sodium calcium exchanger (NCX) regulates calcium extrusion and Trisulfated Disaccharide (TD) acts on NCX decreasing intracellular calcium through the inhibition of the exchange inhibitory peptide (XIP). Objectives The aims of this research are to evaluate TD effects in liver injury secondary to I/R in animals and in vitro action on cytosolic calcium of hepatocytes cultures under calcium overload. Methods Wistar rats submitted to partial liver ischemia were divided in groups: Control: (n = 10): surgical manipulation with no liver ischemia; Saline: (n = 15): rats receiving IV saline before reperfusion; and TD: (n = 15): rats receiving IV TD before reperfusion. Four hours after reperfusion, serum levels of AST, ALT, TNF-α, IL-6, and IL-10 were measured. Liver tissue samples were collected for mitochondrial function and malondialdehyde (MDA) content. Pulmonary vascular permeability and histologic parameters of liver were determined. TD effect on cytosolic calcium was evaluated in BRL3A hepatic rat cell cultures stimulated by thapsigargin pre and after treatment with TD. Results AST, ALT, cytokines, liver MDA, mitochondrial dysfunction and hepatic histologic injury scores were less in TD group when compared to Saline Group (p<0.05) with no differences in pulmonary vascular permeability. In culture cells, TD diminished the intracellular calcium raise and prevented the calcium increase pre and after treatment with thapsigargin, respectively. Conclusion TD decreases liver cell damage, preserves mitochondrial function and increases hepatic tolerance to I/R injury by calcium extrusion in Ca2+ overload situations

Quantum walks: a comprehensive review

Quantum walks, the quantum mechanical counterpart of classical random walks, is an advanced tool for building quantum algorithms that has been recently shown to constitute a universal model of quantum computation. Quantum walks is now a solid field of research of quantum computation full of exciting open problems for physicists, computer scientists, mathematicians and engineers. In this paper we review theoretical advances on the foundations of both discrete- and continuous-time quantum walks, together with the role that randomness plays in quantum walks, the connections between the mathematical models of coined discrete quantum walks and continuous quantum walks, the quantumness of quantum walks, a summary of papers published on discrete quantum walks and entanglement as well as a succinct review of experimental proposals and realizations of discrete-time quantum walks. Furthermore, we have reviewed several algorithms based on both discrete- and continuous-time quantum walks as well as a most important result: the computational universality of both continuous- and discrete- time quantum walks.Comment: Paper accepted for publication in Quantum Information Processing Journa