Investigation of the RTN Distribution of nanoscale MOS devices from subthreshold to on-state

This letter presents a numerical investigation of the statistical distribution of the random telegraph noise (RTN) amplitude in nanoscale MOS devices, focusing on the change of its main features when moving from the subthreshold to the on-state conduction regime. Results show that while the distribution can be well approximated by an exponential behavior in subthreshold, large deviations from this behavior appear when moving toward the on-state regime, despite a low probability exponential tail at high RTN amplitudes being preserved. The average value of the distribution is shown to keep an inverse proportionality to channel area, while the slope of the high-amplitude exponential tail changes its dependence on device width, length, and doping when moving from subthreshold to on-state

Topotecan-vincristine-doxorubicin in stage 4 high risk neuroblastoma patients failing to achieve a complete metastatic response to rapid COJEC : a SIOPEN study

Purpose : Metastatic response to induction therapy for high-risk neuroblastoma is a prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol, only patients with metastatic complete response (CR) or partial response (PR) with <= three abnormal skeletal areas on iodine 123-metaiodobenzylguanidine ([I-123] mIBG) scintigraphy and no bone marrow disease proceed to high dose therapy (HDT). In this study, topotecan-vincristine-doxorubicin (TVD) was evaluated in patients failing to achieve these criteria, with the aim of improving the metastatic response rate. Materials and Methods : Patients with metastatic high-risk neuroblastoma who had not achieved the SIOPEN criteria for HDT after induction received two courses of topotecan 1.5 mg/m(2)/day for 5 days, followed by a 48-hour infusion of vincristine, 2 mg/m(2), and doxorubicin, 45 mg/m(2). Results : Sixty-three patients were eligible and evaluable. Following two courses of TVD, four (6.4%) patients had an overall CR, while 28 (44.4%) had a PR with a combined response rate of 50.8% (95% confidence interval [CI], 37.9 to 63.6). Of these, 23 patients achieved a metastatic CR or a PR with <= 3 mIBG skeletal areas and no bone marrow disease (36.5%; 95% CI, 24.7 to 49.6) and were eligible to receive HDT. Toxicity was mostly haematological, affecting 106 of the 126 courses (84.1%; 95% CI, 76.5 to 90.0), and dose reduction was necessary in six patients. Stomatitis was the second most common nonhematological toxicity, occurring in 20 patients (31.7%). Conclusion : TVD was effective in improving the response rate of high-risk neuroblastoma patients after induction with COJEC enabling them to proceed to HDT. However, the long-term benefits of TVD needs to be determined in randomized clinical trials

Investigating stress in commuting university students

Commuting can be considered as a chronic stressor, since it is often experienced as an unpleasant condition which negatively impacts on the individual psychological, physical and social well-being. Stress becomes dysfunctional and pathological when the individual negatively appraise specific situations. According to the National Institute for Statistics (ISTAT) commuters are people daily travelling out of their residence town for working or studying purposes irrespectively of the distance covered or the mean travel duration. To date, the most studies have been focused on stress among commuting workers; however, it is noteworthy that students represent a wide proportion of commuting population in Italy (about the 23%, conforming to a survey carried out by CENSIS, Centro Studi Investimenti Sociali). In consideration of these data, it is important to cast light on the consequences of commuting on students\u2019 skills and psycho-physical well-being. Present study was aimed at investigating stress among commuting university students, in order to provide answers for some important questions: does commuting affect students\u2019 performance? Does commuting affect daily psychological and physical well-being? What are the commuting characteristics mainly involved in affecting student\u2019s performance and well-being? Three-thousand three-hundred and fifteen commuting students attending the University of Palermo enrolled the study. Non valid data (inconsistent answers) were excluded from the analyses and the final sample consisted of 2949 participants: 60.1% (N = 1773) were females and 39.9% (N = 1176) were males. All students provided socio-anagraphic data and completed an ad hoc self-report questionnaire comprising 20 items. A section of the questionnaire was aimed at collecting information concerning daily commuting, such as place of study (inside or outside the town of residence), estimated daily covered distance, etc. The other section was developed to investigate how commuting students appraise their commuting condition; it investigates three areas: perception of commuting, psycho-physical well-being and disease associated with commuting stressors. The main finding of present study highlights the existence of important differences between commuting students on the basis of means of transportation. It emerged that those using public transports (train, bus, metro) reported a more negative evaluation of their commuting and lower psycho-physical well-being levels than those travelling by private transports. In particular, students travelling by motorcycle described their daily commuting as positive and reported good psycho-physical conditions when arriving at university. This result is in line with previous literature indicating that control and predictability are important subjective factors which mediate the relationship between commuting and stress. People using public transports usually face with uncontrollable events (for example delays or crowding) which facilitate a negative appraisal of commuting. When this is chronically experienced, it may lead to stress and thus lack of energy, irritability, negative mood and difficulties in concentration. All these factors can negatively impact on student\u2019 performance

LO STATO PSICO - FISICO NEGLI STUDENTI UNIVERSITARI PENDOLARI

Lo stress \ue8 un insieme di modificazioni fisiologiche, cognitive, emotive e comportamentali di cui l\u2019individuo ha esperienza nel momento in cui \ue8 richiesto un adattamento alle circostanze ambientali presenti: si configura pertanto come una reazione generale a situazioni specifiche e, non ha una connotazione positiva o negativa, svolgendo primariamente una funzione di tipo adattivo. Ci\uf2 che rende disfunzionale e \u201cpatologico\u201d lo stress \ue8 il modo in cui l\u2019individuo valuta la situazione con la quale si trova a rapportarsi: in questi casi si parla pertanto di distress, ovvero \u201cstress negativo\u201d (Selye, 1956). Gli stimoli e le situazioni che, valutate negativamente, determinano una reazione di distress sono definiti stressors; questi possono essere acuti (si verificano una sola volta e per un periodo limitato di tempo) oppure cronici (di lunga durata). A loro volta, gli stressors cronici possono essere intermittenti o propriamente cronici. Nel primo caso, si presentano a intervalli di tempo regolari, hanno una durata limitata e perci\uf2 sono pi\uf9 o meno prevedibili; nel secondo, invece, sono rappresentati da situazioni di lunga durata, che permeano la vita dell\u2019individuo e che diventano stressanti nel momento in cui ostacolano in maniera persistente il perseguimento degli obiettivi della persona. Due sono le reazioni fisiologiche principali che caratterizzano la risposta di stress: muscolari (tensione muscolare o immobilizzazione) e neurovegetative (dovute a un\u2019eccessiva stimolazione del Sistema Nervoso Autonomo simpatico). Gli effetti di queste reazioni fisiologiche, andando a combinarsi con quella che \ue8 l\u2019interpretazione che la persona da della situazione e la propria esperienza emotiva, determinano alcuni dei principali sintomi riferiti legati allo stress: emicrania, tachicardia, iperventilazione, difficolt\ue0 di concentrazione, umore depresso, irritabilit\ue0, stanchezza, affaticamento

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives

Experimental and Simulation Study of a High Current 1D Silicon Nanowire Transistor Using Heavily Doped Channels

Silicon nanowires have numerous potential applications, including transistors, memories, photovoltaics, biosensors and qubits [1]. Fabricating a nanowire with the required characteristics for a specific application, however, poses some challenges. For example, a major challenge is that, as the transistors dimensions are reduced, it is difficult to maintain a low off-current (Ioff) whilst simultaneously maintaining a high on-current (Ion). Some sources of this parasitic leakage current include quantum mechanical tunnelling, short channel effects and statistical variability [2, 3]. A variety of new architectures, including ultra-thin silicon-on-insulator (SOI), double gate, FinFETs, tri-gate, junctionless and gate all-around (GAA) nanowire transistors, have therefore been developed to improve the electrostatic control of the conducting channel. This is essential since a low Ioff implies low static power dissipation and it will therefore improve power management in the multi-billion transistors circuits employed globally in microprocessors, sensors and memories

DISTO data on Kpp

The data from the DISTO Collaboration on the exclusive pp -> p K+ Lambda production acquired at T_p = 2.85 GeV have been re-analysed in order to search for a deeply bound K- pp (= X) state, to be formed in the binary process pp -> K+ X. The preliminary spectra of the DeltaM_{K+} missing-mass and of the M_{p Lambda} invariant-mass show, for large transverse-momenta of protons and kaons, a distinct broad peak with a mass M_X = 2265 +- 2 MeV/c^2 and a width Gamma_X = 118 +- 8 MeV/c^2.Comment: 8 pages, 4 figures. Talk presented at the "10th International Conference on Hypernuclear and Strange Particle Physics" (HYP-X), Tokai, Ibaraki, Japan, September 14th-18th, 2009. To appear in the proceeding