Evaluation and toxicological quantification of undeclared allopathics and adulterated synthetic steroids in herbal antihypertensive preparations

Purpose: To evaluate raw and finished dosage form of herbal antihypertensives for quantification of undeclared allopathic contents and synthetic steroids adulteration in each unit and in total daily dose.Methods: Analysis of herbal products for allopathic drugs adulteration was carried out using HPLC techniques. The methods were reproduced with optimized extraction and chromatographic conditions. Calibration curves were reconstructed for validation purposes.Results: The herbal products were adulterated with various synthetic drugs. The concentrations (mean ± SD) were: atenolol (50.06 ± 1.20 mg/unit dose),  propranolol (20.30 ± 0.44 mg/unit dose, 28.26 ± 0.06 mg/unit dose, 15.40 ± 1.58 mg/unit dose), ACE inhibitors i.e. captopril (52.99 ± 0.49 mg/unit dose) and frusemide (42.02 ± 0.88 mg/unit dose). For the synthetic steroids, the levels (mean ± SD) were prednisolone (13.67 ± 0.50 mg/unit dose), methyl prednisolone (4.18 ± 0.02 mg/unit dose), betamethasone (0.56 ± 0.06 mg/unit dose) and dexamethasone (1.75 ± 0.11 mg/unit dose).Conclusion: Administration of adulterated remedies can cause severe toxicity and is a serious safety concerns for public health. Therefore, to maximize consumer safety, appropriate rules and regulations should be developed for registration of herbal remedies.Keywords: Herbal medicines, Adulterants, Allopathic drugs, Synthetic steroid

Outcome of Microsurgical Clipping of Ruptured Anterior Circulation Aneurysms

Objective: The objective of the study was to analyze the operative outcome of microsurgical clipping in Ruptured Anterior Circulation Aneurysms.Materials and Methods: Twenty patients with Ruptured Anterior Circulation aneurysms were treated with surgical clipping. All the patients were evaluated pre-operatively according to Hunt & Hess and WFNS grading scales. Patients with grade I, II, and III were operated. All the aneurysms were clipped through Pterional approach under General anesthesia and Yasargil Aneurysm clips of appropriate sizes were used in each patient. Outcome was analyzed according to Glasgow Outcome Scale at the end of six months of follow up in each patient.Results: In this series of twenty cases, the mean patient age was 49 years. Lesion location included, the ACA/A. Com 55% (n = 11), the Middle Cerebral artery 25% (n = 5), P. Com 15% (n = 3), Ophthalmic artery 5% (n = 1). Sex distribution, female 55% (n = 11) and male 45% (n = 9). Per-operative complications, rupture of aneurysm 20% (n = 4), and damage to perforating branches of MCA 5% (n = 1). Conclusions: Surgical clipping still is the most efficient treatment of Ruptured Anterior Circulation aneurysm at the beginning of the new millennium. Anterior Communicating Artery is the commonest location of aneurysms. Major determinants of outcome are Hunt & Hess, WFNS grades on admission and the age of the patient

Outcome of Microsurgical Clipping of Ruptured Anterior Circulation Aneurysms

Objective: The objective of the study was to analyze the operative outcome of microsurgical clipping in Ruptured Anterior Circulation Aneurysms.Materials and Methods: Twenty patients with Ruptured Anterior Circulation aneurysms were treated with surgical clipping. All the patients were evaluated pre-operatively according to Hunt & Hess and WFNS grading scales. Patients with grade I, II, and III were operated. All the aneurysms were clipped through Pterional approach under General anesthesia and Yasargil Aneurysm clips of appropriate sizes were used in each patient. Outcome was analyzed according to Glasgow Outcome Scale at the end of six months of follow up in each patient.Results: In this series of twenty cases, the mean patient age was 49 years. Lesion location included, the ACA/A. Com 55% (n = 11), the Middle Cerebral artery 25% (n = 5), P. Com 15% (n = 3), Ophthalmic artery 5% (n = 1). Sex distribution, female 55% (n = 11) and male 45% (n = 9). Per-operative complications, rupture of aneurysm 20% (n = 4), and damage to perforating branches of MCA 5% (n = 1). Conclusions: Surgical clipping still is the most efficient treatment of Ruptured Anterior Circulation aneurysm at the beginning of the new millennium. Anterior Communicating Artery is the commonest location of aneurysms. Major determinants of outcome are Hunt & Hess, WFNS grades on admission and the age of the patient

Optimized Energy Control Scheme for Electric Drive of EV Powertrain Using Genetic Algorithms

Automotive applications often experience conflicting-objective optimization problems focusing on performance parameters that are catered through precisely developed cost functions. Two such conflicting objectives which substantially affect the working of traction machine drive are maximizing its speed performance and minimizing its energy consumption. In case of an electric vehicle (EV) powertrain, drive energy is bounded by battery dynamics (charging and capacity) which depend on the consumption of drive voltage and current caused by driving cycle schedules, traffic state, EV loading, and drive temperature. In other words, battery consumption of an EV depends upon its drive energy consumption. A conventional control technique improves the speed performance of EV at the cost of its drive energy consumption. However, the proposed optimized energy control (OEC) scheme optimizes this energy consumption by using robust linear parameter varying (LPV) control tuned by genetic algorithms which significantly improves the EV powertrain performance. The analysis of OEC scheme is conducted on the developed vehicle simulator through MATLAB/Simulink based simulations as well as on an induction machine drive platform. The accuracy of the proposed OEC is quantitatively assessed to be 99.3% regarding speed performance which is elaborated by the drive speed, voltage, and current results against standard driving cycles

CASUAL COMPARATIVE ANALYSIS OF INCIDENCE & EXTENT OF ERECTILE DYSFUNCTION AMONG SMOKERS & NON-SMOKERS PRESENTING AT A MALE SEXUAL HEALTH CLINIC IN HYDERABAD

Background: The term ‘‘erectile dysfunction’’ (ED) is defined as the inability to achieve and maintain an erection sufficient for satisfactory sexual performance. ED affects millions of men throughout the world, with a strong negative effect on the quality of life and well-being of men and couples. The etiology of ED once was considered to be mainly psychogenic. However, because of advances in the understanding of the physiology of erection and the development of modern diagnostic techniques, it is now generally agreed that the etiology of ED is often multifactorial, with psychological, neurological, endocrine, vascular, traumatic or iatrogenic causes.Objective: Smoking, among many other causes, is believed to be associated with smoking. This study hopes to compare the incidence and extent of erectile dysfunction (ED) among smokers and non-smokers presenting at a male sexual health clinic in an attempt to further understand the association. Methodology: This casual-comparative analysis was conducted upon a total of 64 male patients presenting with erectile dysfunction at a sexual health clinic. Inquiries regarding the habit of smoking were made using a structured interview based questionnaire and extent of erectile dysfunction was investigated using the “International Index of Erectile Function (IIEF-5) Questionnaire”. The data obtained was analyzed using MS. Excel 2017 and SPSS v. 21.0. Results: Smokers showed a markedly high incidence when compared to non-smokers. The extent of erectile dysfunction too was observed to be significantly high among smokers in comparison to non-smokers. Ex-smokers too showed a more worrisome IIEF-5 score, when compared to non-smokers. Conclusion: The results obtained, make it abundantly clear that, the association between the incidence and extent of erectile dysfunction and smoking is strong. Although, the research does not attempt to control co-founding variables, the results can be regarded as reliable due to the sheer difference in incidence and extent of erectile dysfunction between smokers and non-smokers. Keywords: Erectile Dysfunction, Smoking, The International Index of Erectile Function (IIEF-5) Questionnaire, Sexual Health & Sex Related Quality of Life

Albuminuria in diabetic patients with stroke.

Diabetes is a major health burden worldwide. There is a close association between albuminuria and development of stroke in diabetics. This study was conducted to determine the frequency of albuminuria among diabetic patients presenting with strok