Diagnostic Imaging and Radiation Therapy in the Arab World: A New Model of Advanced Practice

This study aimed at suggesting a new model for advanced practice in the diagnostic imaging and radiation therapy in the Arab World by presenting a comparative study between the different medical imaging techniques, the concepts, benefits, risks and medical applications of these techniques has been presented with details. Attempting For building a new model of advanced practice for the diagnostic role of  imaging and radiation therapy in the Arab World; by analyzing the current status of the imaging and radiation therapy in the Arab World, and then surveying the different medical imaging techniques. Then  to suggest a model of best practices upon the outcomes of the study

Chitosan-titanium oxide fibers supported zero-valent nanoparticles: Highly efficient and easily retrievable catalyst for the removal of organic pollutants

Abstract Different chitosan-titanium oxide (CS-TiO2-x, with x = TiO2 loadings of 1, 5, 10,15 and 20 wt%) nanocomposite fibers were prepared and kept separately in each salt solution of CuSO4, CoNO3, AgNO3 and NiSO4 to adsorb Cu2+, Co2+, Ag+, and Ni+ ions, respectively. The metal ions loaded onto CS-TiO2 fibers were reduced to their respective zero-valent metal nanoparticles (ZV-MNPs) like Cu0, Co0, Ag0 and Ni0 by treating with NaBH4. The CS-TiO2 fibers templated with various ZV-MNPs were characterized and investigated for their catalytic efficiency. Among all prepared ZV-MNPs, Cu0 nanoparticles templated on CS-TiO2-15 fibers exhibited high catalytic efficiency for the reduction of dyes (methyl orange (MO), congo red (CR), methylene blue (MB) and acridine orange (AO)) and nitrophenols (4-nitrohphenol (4-NP), 2-nitrophenol (2-NP), 3-nitrophenol (3-NP) and 2,6-dinitrophenol (2,6-DNP)). Besides the good catalytic activities of Cu/CS-TiO2-15 fibers, it could be easily recovered by simply pulling the fiber from the reaction medium

Complications of ultrasound-guided percutaneous native kidney biopsies in children: A single center experience

Introduction: Percutaneous kidney biopsy is a necessary tool to diagnose many kidney diseases. However, major complications were reported in adults, including bleeding in the kidney or around it, creation of arteriovenous fistula, wound infection, damage to adjacent organs, or even loss of the kidney. Such complications can rapidly develop serious consequences. Exploring risk factors might help in preventing them.Objective: The current study aims to evaluate and explore the complications that happened after percutaneous kidney biopsy in children and associated risk factors.Methodology: A retrospective record-based study was conducted by reviewing the medical records of children with post-ultrasound-guided percutaneous kidney biopsy complications at King Saud Medical City, a tertiary hospital in Riyadh, Saudi Arabia during the period from May 2014 to June 2021. Data were extracted using pre-structured data collection sheet. Data collected included children’s age, gender, primary disease, laboratory findings, and kidney complications with needed management. Results: The study identified 76 children who had undergone 86 ultrasound-guided percutaneous kidney biopsies in the study period and fulfil the inclusion criteria. Children’s ages ranged from 1 years to 15 years with a mean age of 7.3 ± 4.0 years old. Most of the study children had nephrotic syndrome (61.6%; 53), followed by glomerulonephritis (25.6%; 22). Thirty-five (40.7%) children developed at least one of the complications. The most-reported complication was microscopic haematuria (32.6%; 28), followed by gross haematuria (3.5%; 3), Flank pain was reported among 3 (3.5%) children also and hematoma (1 child), only 2 children (3.9%) among those who had no complications recorded Haemoglobin drop > 2 g/dl compared to 3 of those who had complications with no statistical significance (p = .365). Prothrombin time was significantly higher among children who had renal complications than others who had not (11.7 ± 1.8 vs. 10.8 ± 1.2 seconds; p = .022).Conclusion: Suggestive by the low need to intervene in complications, ultrasound-guided percutaneous kidney biopsy is a relatively safe procedure in children. Even in the most commonly observed complication, i.e. hemorrhagic ones, blood transfusion is rarely needed

Silver Nanoparticle Production by Ruta graveolens and Testing Its Safety, Bioactivity, Immune Modulation, Anticancer, and Insecticidal Potentials

Ruta graveolens, a plant belonging to the family Rutaceae, is traditionally used as a medicinal plant and a flavoring agent in food. This work aimed to prepare silver nanoparticles (AgNPs) using the ethanol extract from R. graveolens leaves and test different biological activities as well as insecticidal potentials in the extract and extract prepared AgNPs. Dried and powdered R. graveolens leaves were subjected to extraction using ethanol, and this extract was used to synthesize AgNPs. AgNP synthesis was monitored by the change in color, UV spectrophotometry, and electron microscopy (scanning). Fourier transform infrared (FT-IR) spectroscopy was used to monitor the functional groups in the extracts. Immunological, physiological, anticancer, antibacterial, and insecticidal potentials of the extract and its prepared AgNPs were tested. Results showed the ability of the leaf extract to synthesize. SEM examination revealed a spherical shape of AgNPs with a size of 40–45 nm. The extract contained many functional groups as indicated by FT-IR. The extract alone inhibited the growth of normal rat splenic cells, while the extract containing AgNPs stimulated its growth. Extract alone stimulated HeLa cell proliferation and inhibited HepG2 growth, while both cell line growth was inhibited by the extract containing AgNPs. Both the extract and extract with AgNPs were safe on RBCs and did not cause any severe elevation in liver enzymes. The extract alone and with AgNPs showed insecticidal activity against Culex pipiens. Our findings suggest that the R. graveolens leaf extract, alone or with AgNPs, is biologically safe on animal cells and has antibacterial, insecticidal, and immunomodulation potentials

Utilizing Biomass-Based Graphene Oxide–Polyaniline–Ag Electrodes in Microbial Fuel Cells to Boost Energy Generation and Heavy Metal Removal

Although regarded as environmentally stable, bioelectrochemical fuel cells or, microbial fuel cells (MFCs) continue to face challenges with sustaining electron transport. In response, we examined the performance of two graphene composite-based anode electrodes—graphene oxide (GO) and GO–polymer–metal oxide (GO–PANI–Ag)—prepared from biomass and used in MFCs. Over 7 days of operation, GO energy efficiency peaked at 1.022 mW/m2 and GO–PANI–Ag at 2.09 mW/m2 . We also tested how well the MFCs could remove heavy metal ions from synthetic wastewater, a secondary application of MFCs that offers considerable benefits. Overall, GO–PANI–Ag had a higher removal rate than GO, with 78.10% removal of Pb(II) and 80.25% removal of Cd(II). Material characterizations, electrochemical testing, and microbial testing conducted to validate the anodes performance confirmed that using new materials as electrodes in MFCs can be an attractive approach to improve the electron transportation. When used with a natural organic substrate (e.g., sugar cane juice), they also present fewer challenges. We also optimized different parameters to confirm the efficiency of the MFCs under various operating conditions. Considering those results, we discuss some lingering challenges and potential possibilities for MFC

A Combined Experimental and Computational Study of Novel Benzotriazinone Carboxamides as Alpha-Glucosidase Inhibitors

Diabetes is a chronic metabolic disorder of the endocrine system characterized by persistent hyperglycemia appears due to the deficiency or ineffective use of insulin. The glucose level of diabetic patients increases after every meal and medically recommended drugs are used to control hyperglycemia. Alpha-glucosidase inhibitors are used as antidiabetic medicine to delay the hydrolysis of complex carbohydrates. Acarbose, miglitol, and voglibose are commercial drugs but patients suffer side effects of flatulence, bloating, diarrhea, and loss of hunger. To explore a new antidiabetic drug, a series of benzotriazinone carboxamides was synthesized and their alpha-glucosidase inhibition potentials were measured using in vitro experiments. The compounds 14k and 14l were found to be strong inhibitors compared to the standard drug acarbose with IC50 values of 27.13 ± 0.12 and 32.14 ± 0.11 μM, respectively. In silico study of 14k and 14l was carried out using molecular docking to identify the type of interactions developed between these compounds and enzyme sites. Both potent compounds 14k and 14l exhibited effective docking scores by making their interactions with selected amino acid residues. Chemical hardness and orbital energy gap values were investigated using DFT studies and results depicted affinity of 14k and 14l towards biological molecules. All computational findings were found to be in good agreement with in vitro results

Effects of Smokeless Tobacco on Color Stability and Surface Roughness of 3D-Printed, CAD/CAM-Milled, and Conventional Denture Base Materials: An In Vitro Study

Tobacco consumption in its different forms can affect the optical and surface properties of dental materials that are used in the oral cavity. Thus, the present study was conducted to evaluate the effects of two commercially available smokeless tobacco products on the color stability and surface roughness of denture base resins that were fabricated using three different techniques (CAD/CAM milling, 3D printing, and conventional heat polymerization). A total of 126 denture base resin specimens were fabricated using the three different manufacturing techniques (n = 42 each). Specimens from each group were further subdivided into three subgroups (n = 14 each) and immersed in three different immersion media (a khaini suspension, a tabbaq suspension, and artificial saliva). The differences in color and surface roughness were assessed according to data that were collected and statistically analyzed using SPSS version 24.0. The tabbaq smokeless tobacco was found to cause greatest changes in color and surface roughness; the effect was observed to be highest in the 3D-printed specimens followed by the conventional heat-polymerized and CAD/CAM milled specimens. The mean changes in color and surface roughness were the highest for the tabbaq smokeless tobacco followed by the khaini smokeless tobacco and the artificial saliva. Statistically significant (p-value < 0.05) differences were observed among all techniques and suspensions. We concluded that the mean changes in color and surface roughness were significantly higher for the 3D-printed dentures compared to the conventional heat-polymerized and CAD/CAM-milled dentures. Thus, the results of the present study strengthened the concept that tobacco in any form can lead to changes in the color and surface roughness of denture base materials