146 research outputs found
Generalized Ladder Operators for Shape-invariant Potentials
A general form for ladder operators is used to construct a method to solve
bound-state Schr\"odinger equations. The characteristics of supersymmetry and
shape invariance of the system are the start point of the approach. To show the
elegance and the utility of the method we use it to obtain energy spectra and
eigenfunctions for the one-dimensional harmonic oscillator and Morse potentials
and for the radial harmonic oscillator and Coulomb potentials.Comment: in Revte
An Algebraic Construction of Generalized Coherent States for Shape-Invariant Potentials
Generalized coherent states for shape invariant potentials are constructed
using an algebraic approach based on supersymmetric quantum mechanics. We show
this generalized formalism is able to: a) supply the essential requirements
necessary to establish a connection between classical and quantum formulations
of a given system (continuity of labeling, resolution of unity, temporal
stability, and action identity); b) reproduce results already known for
shape-invariant systems, like harmonic oscillator, double anharmonic,
Poschl-Teller and self-similar potentials and; c) point to a formalism that
provides an unified description of the different kind of coherent states for
quantum systems.Comment: 14 pages of REVTE
Gestational weght gain and body mass index in pre-school children
To examine the association between gestational weight gain (GWG) and body mass index (BMI) in pre-school children.info:eu-repo/semantics/publishedVersio
Fetal stem cells obtained from amniotic fluid and wharton's jelly expanded using platelet lysate for tissue engineering applications
Extra-embryonic tissues, such as amniotic fluid (AF) and Wharton´s Jelly (WJ) of
umbilical cord, offer many advantages over both embryonic and adult stem cell sources.
These tissues are routinely discarded at parturition and the extracorporeal nature of
these cell sources facilitates isolation, as well as the comparatively large volume and
ease of physical manipulation theoretically increases the number of stem cells that can
be isolated.
Autologous approaches to use MSCs, namely from bone marrow, have difficulties
regarding the limited availability of large amounts of cells from the patient. Fetal stem
cells appear to have even more pronounced immunomodulatory properties than adult
MSCs (1, 2). This allogeneic escape mechanism may be of therapeutic value, because
transplantation of allogeneic human MSCs in stock would be readily available, as
opposed to the culture of autologous cells for subsequent transplantation.
Cell expansion protocols are based on the use of media supplemented with fetal bovine
serum (FBS) as a source of nutrientes and growth factors. The animal serum is not
completely safe, once there is a possibility of contamination by animal viroses, prions or
others contaminants and it is described that FBS used systematically in MSCs
subcultivation induces more humoral immune response (3). Additionally anti-FBS
antibodies could be detected in patients after receiving MSCs expanded in FBS (4).
Platelet lysate (PL) has enormous possibilities in cell therapy, namely because of the
high concentration of growth factors that promotes higher cell expansion, such as tissue
regeneration (5). A recent study showed that proliferation of MSCs was much higher on
PL gel compared to tissue culture plastic (6). The immunomodulatory properties of
MSCs are maintained when expanded in culture medium supplemented with PL (7)
Based on these premises we isolated fetal stem cells from AF obtained from
amniocentesis and WJ from umbilical cords. These cells were plated and expanded in low density numbers in basal culture medium with FBS or either supplemented with PL.
In each passage cells were counted for proliferation kinetics and prepared for flow
cytometry analysis. Expanded populations were analysed both population size and
complexity and for the MSCs well-known surface markers (CD34, CD45, CD73, CD44,
CD106, CD105, CD29, CD90, CD31) and markers related with immune response (HLADR,
80, 83, 86) and embryonic markers SSEA-4 and TRA-1-60
Intermediate energy Coulomb excitation as a probe of nuclear structure at radioactive beam facilities
The effects of retardation in the Coulomb excitation of radioactive nuclei in
intermediate energy collisions (Elab ~100 MeV/nucleon) are investigated. We
show that the excitation cross sections of low-lying states in 11Be,
{38,40,42}S and {44,46}Ar projectiles incident on gold and lead targets are
modified by as much as 20% due to these effects. The angular distributions of
decaying gamma-rays are also appreciably modified.Comment: 21 pages, 3 figures, Phys. Rev. C, in pres
Coherent states of P{\"o}schl-Teller potential and their revival dynamics
A recently developed algebraic approach for constructing coherent states for
solvable potentials is used to obtain the displacement operator coherent state
of the P\"{o}schl-Teller potential. We establish the connection between this
and the annihilation operator coherent state and compare their properties. We
study the details of the revival structure arising from different time scales
underlying the quadratic energy spectrum of this system.Comment: 13 pages, 6 figure
Synergistic impact of endurance training and intermittent hypobaric hypoxia on cardiac function and mitochondrial energetic and signaling
Background
Intermittent hypobaric-hypoxia (IHH) and endurance-training (ET) are cardioprotective strategies against stress-stimuli. Mitochondrial modulation appears to be an important step of the process. This study aimed to analyze whether a combination of these approaches provides additive or synergistic effects improving heart-mitochondrial and cardiac-function.
Methods
Two-sets of rats were divided into normoxic-sedentary (NS), normoxic-exercised (NE, 1 h/day/5 weeks treadmill-running), hypoxic-sedentary (HS, 6000 m, 5 h/day/5 weeks) and hypoxic-exercised (HE) to study overall cardiac and mitochondrial function. In vitro cardiac mitochondrial oxygen consumption and transmembrane potential were evaluated. OXPHOS subunits and ANT protein content were semi-quantified by Western blotting. HIF-1α, VEGF, VEGF-R1 VEGF-R2, BNP, SERCA2a and PLB expressions were measured by qRT-PCR and cardiac function was characterized by echocardiography and hemodynamic parameters.
Results
Respiratory control ratio (RCR) increased in NE, HS and HE vs. NS. Susceptibility to anoxia/reoxygenation-induced dysfunction decreased in NE, HS and HE vs. NS. HS decreased mitochondrial complex-I and -II subunits; however HE completely reverted the decreased content in complex-II subunits. ANT increased in HE. HE presented normalized ventricular–arterial coupling (Ea) and BNP myocardial levels and significantly improved myocardial performance as evaluated by increased cardiac output and normalization of the Tei index vs. HS.
Conclusion
Data demonstrates that IHH and ET confer cardiac mitochondria with a more resistant phenotype although without visible addictive effects at least under basal conditions. It is suggested that the combination of both strategies, although not additive, results into improved cardiac function
TRY plant trait database - enhanced coverage and open access
Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives
Non-matching predictions from different models simulating the effects of elevated atmospheric CO2 on the Amazon forest’s functional diversity
The continuous rising of atmospheric carbon dioxide (CO2) concentration is undoubtedly affecting the resilience of tropical forests worldwide. However, the magnitude of such effects is poorly known, limiting our capacity to assess the vulnerability of tropical forests and to improve their representation by models. Functional diversity (FD) is an important component of biodiversity enhancing ecosystem resilience, as high FD can provide higher response diversity and capacity to buffer against climate change. How FD is represented by different Dynamic Global Vegetation Models (DGVMs) may affect how such models predict the impacts of environmental changes on hyperdiverse ecosystems. We compared simulations of five trait-based DGVMs (i.e., with flexible, variable traits) constrained with data from the Amazon rainforest in the scope of the AmazonFACE project. Simulations were conducted considering initial high or low diversity scenarios under ambient and elevated CO2 (400 ppm and 600 ppm, respectively). We searched for correspondence between the functional identity of simulated plant strategies and their ecophysiological performances under elevated CO2. As models take different approaches to simulating functional trait distributions and they differ in their structure and in the trade-offs implemented, we found important intermodel differences in simulated results. Nevertheless, we took advantage of these differences in order to assess the most likely scenarios in terms of functional composition under elevated CO2, as well as to give feedback for better harmonization of model inputs and outputs and future model improvements. In the face of the pessimistic scenarios that project a continuous increase in CO2 levels, resolving the divergent responses among model predictions is critical, given the global importance of the Amazon rainforest's biodiversity and climate regulation, as well as the approximately 30 million people that directly or indirectly depend on the forest for their well-being
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