Social media: friend or foe in the COVID-19 pandemic?

Submitted by Raphael Belchior ([email protected]) on 2020-05-20T16:12:39Z No. of bitstreams: 1 1807-5932-clin-75-e1953.pdf: 128147 bytes, checksum: 10a855d459c314e6c24aed9a73bba53c (MD5)Approved for entry into archive by Raphael Belchior ([email protected]) on 2020-05-20T22:59:59Z (GMT) No. of bitstreams: 1 1807-5932-clin-75-e1953.pdf: 128147 bytes, checksum: 10a855d459c314e6c24aed9a73bba53c (MD5)Made available in DSpace on 2020-05-20T23:00:00Z (GMT). No. of bitstreams: 1 1807-5932-clin-75-e1953.pdf: 128147 bytes, checksum: 10a855d459c314e6c24aed9a73bba53c (MD5) Previous issue date: 2020Montefiore Medical Center. Department of Surgery. The Bronx, NY, USA.Real Hospital Português. Cardiologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhaes. Departamento de Saúde Coletiva. Recife, PE, Brasil

Multimodality imaging methods and systemic biomarkers in classical low-flow low-gradient aortic stenosis: Key findings for risk stratification

ObjectivesThe aim of the present study is to assess multimodality imaging findings according to systemic biomarkers, high-sensitivity troponin I (hsTnI) and B-type natriuretic peptide (BNP) levels, in low-flow, low-gradient aortic stenosis (LFLG-AS).BackgroundElevated levels of BNP and hsTnI have been related with poor prognosis in patients with LFLG-AS.MethodsProspective study with LFLG-AS patients that underwent hsTnI, BNP, coronary angiography, cardiac magnetic resonance (CMR) with T1 mapping, echocardiogram and dobutamine stress echocardiogram. Patients were divided into 3 groups according to BNP and hsTnI levels: Group 1 (n = 17) when BNP and hsTnI levels were below median [BNP < 1.98 fold upper reference limit (URL) and hsTnI < 1.8 fold URL]; Group 2 (n = 14) when BNP or hsTnI were higher than median; and Group 3 (n = 18) when both hsTnI and BNP were higher than median.Results49 patients included in 3 groups. Clinical characteristics (including risk scores) were similar among groups. Group 3 patients had lower valvuloarterial impedance (P = 0.03) and lower left ventricular ejection fraction (P = 0.02) by echocardiogram. CMR identified a progressive increase of right and left ventricular chamber from Group 1 to Group 3, and worsening of left ventricular ejection fraction (EF) (40 [31–47] vs. 32 [29–41] vs. 26 [19–33]%; p < 0.01) and right ventricular EF (62 [53–69] vs. 51 [35–63] vs. 30 [24–46]%; p < 0.01). Besides, there was a marked increase in myocardial fibrosis assessed by extracellular volume fraction (ECV) (28.4 [24.8–30.7] vs. 28.2 [26.9–34.5] vs. 31.8 [28.9–35.5]%; p = 0.03) and indexed ECV (iECV) (28.7 [21.2–39.1] vs. 28.8 [25.4–39.9] vs. 44.2 [36.4–51.2] ml/m2, respectively; p < 0.01) from Group 1 to Group 3.ConclusionsHigher levels of BNP and hsTnI in LFLG-AS patients are associated with worse multi-modality evidence of cardiac remodeling and fibrosis

Ervais em queda : transformações no campo no extremo sul de Mato Grosso (1940-1970)

A porção mais meridional do antigo estado de Mato Grosso, sobretudo a partir da década de 1940, passou a integrar-se à expansão da fronteira agrícola, particularmente intensa na área onde foi implantada a Colônia Agrícola Nacional de Dourados (CAND, 1943). Este trabalho busca identificar as particularidades de tal processo num espaço mais específico, aqui denominado por extremo sul de Mato Grosso, ou cone sul do atual Mato Grosso do Sul. Analisa-se o contexto de declínio da presença da Companhia Matte Larangeira, o impacto das políticas do Estado Novo, o avanço das frentes pioneiras, as relações de trabalho e as transformações ocorridas no meio rural, num período de transição que prepara a região para o desenvolvimento ulterior, já mais de acordo com a modernização capitalista do campo e cujas consequências sociais são verificáveis ainda hoje