1 research outputs found
POTENTIAL ADMINISTRATION OF LIPOIC ACID AND COENZYME Q AGAINST ADIPOGENSIS: TARGET FOR WEIGHT REDUCTION
Background: Body overweight and obesity were considered as a risk factor for many systemic diseases as diabetic
hypertension, cardiovascular diseases, and some cancers. The lipoic acid and Co Q are considered as coenzymes
needed for enhancement metabolic rate. The goal of this study is to evaluate the anti-obese effect of lipoic acid alone or
combined with Co-Q in rats.
Materials and Methods: Ninety male albino rats (100–150g) were used in this study, divided into six groups (15
each). Group I: Normal rats fed normal diet. Group II: Rats fed high fat diet (HFD). Group III: Rats fed HFD were
given lipoic acid (10 μg/kg b w /day) intra-gastric by stomach tube. Group IV: Rats fed HFD were given Co-Q (10 μg
/kg b.w/day) intra-gastric. Group V: Rats fed HFD were given lipoic acid (50 mg/kg b w /day) and Co-Q (10 μg /kg b.
w/day). Group VI: Rats were given orlistat intra-gastric (10 mg/kg b w/day) as positive control for 6 weeks. Serum was
subjected for determination of lipid profile, liver function tests atherogenic factor and lipoprotein lipase.
Results: It was found that treatment with lipoic acid or Co-Q or combined showed increase in the activity of
lipoprotein lipase