8,857 research outputs found

    Diagnosis of Centrifugal Pump Faults Using Vibration Methods

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    Pumps are the largest single consumer of power in industry. This means that faulty pumps cause a high rate of energy loss with associated performance degradation, high vibration levels and significant noise radiation. This paper investigates the correlations between pump performance parameters including head, flow rate and energy consumption and surface vibration for the purpose of both pump condition monitoring and performance assessment. Using an in-house pump system, a number of experiments have been carried out on a centrifugal pump system using five impellers: one in good condition and four others with different defects, and at different flow rates for the comparison purposes. The results have shown that each defective impeller performance curve (showing flow, head, efficiency and NPSH (Net Positive Suction Head) is different from the benchmark curve showing the performance of the impeller in good condition. The exterior vibration responses were investigated to extract several key features to represent the healthy pump condition, pump operating condition and pump energy consumption. In combination, these parameter allow an optimal decision for pump overhaul to be made [1]

    Early Failure Detection and Diagnostics of High Speed Self Aligning Journal Bearing

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    Because of their high load carrying capacity and low cost, journal bearings are widely used to support the rotor of industrial machinery with high loads, such as steam turbines, centrifugal compressors and pumps. However, sudden catastrophic failure journal bearings can result in huge economic loss and high safety problems. It is necessary to develop effective condition monitoring technologies to detect and diagnose the failures at early stage and avoid such catastrophic failure. Previous researchers have studied the low frequency vibration characteristics as well as the high frequency vibration and acoustics emission for the early detection of journal bearing failure. However, these studies give relatively little information to the vibro-acoustic characteristics of high speed self aligning journal bearings. This paper focuses on the condition monitoring of high speed self aligning journal bearings through vibro-acoustic analysis

    Prediction of metal pm emission in rail tracks for condition monitoring application

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    Exposure to particulate material (PM) is a major health concern in megacities across the world which use trains as a primary public transport. PM emissions caused by railway traffic have hardly been investigated in the past, due to their obviously minor influence on the atmospheric air quality compared to automotive transport. However, the electrical train releases particles mainly originate from wear of rails track, brakes, wheels and carbon contact stripe which are the main causes of cardio-pulmonary and lung cancer. In previous reports most of the researchers have focused on case studies based PM emission investigation. However, the PM emission measured in this way doesn’t show separately the metal PM emission to the environment. In this study a generic PM emission model is developed using rail wheel-track wear model to quantify and characterise the metal emissions. The modelling has based on Archard’s wear model. The prediction models estimated the passenger train of one set emits 6.6mg/km-train at 60m/s speed. The effects of train speed on the PM emission has been also investigated and resulted in when the train speed increase the metal PM emission decrease. Using the model the metal PM emission has been studied for the train line between Leeds and Manchester to show potential emissions produced each day. This PM emission characteristics can be used to monitor the brakes, the wheels and the rail tracks conditions in future

    Transcriptomic profiles of aging in purified human immune cells

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    Strength and hydration properties of reactive MgO-activated ground granulated blastfurnace slag paste

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    Ground granulated blastfurnace slag (GGBS) is widely used as a partial replacement for Portland cement or as the major component in the alkali-activated cement to give a clinker-free binder. In this study, reactive MgO is investigated as a potentially more practical and greener alternative as a GGBS activator. This paper focuses on of the hydration of GGBS, activated by two commercial reactive MgOs, with contents ranging from 2.5% to 20% up to 90 days. The hydration kinetics and products of MgO–GGBS blends were investigated by selective dissolution, thermogravimetric analysis, X-ray diffraction and scanning electron microscopy techniques. It was found that reactive MgO was more effective than hydrated lime in activating the GGBS based on unconfined compressive strength and the efficiency increased with the reactivity and the content of the MgO. It is hence proposed that reactive MgO has the potential to serve as an effective and economical activator for GGBS.The authors are grateful to Cambridge Trust and China Scholarship Council (CSC) for their financial help of the PhD studentship for the first author.This is the accepted manuascript for a paper published in Cement and Concrete Composites, Volume 57, March 2015, Pages 8–16, doi:10.1016/j.cemconcomp.2014.10.00

    Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups

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    We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare clumping-and-thresholding (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs developed from multiple independent GWAS, perform best across all race/ethnic backgrounds. Stratified analysis in All of Us shows that PRSs are better predictive of BP in females compared to males, individuals without obesity, and middle-aged (40-60 years) compared to older and younger individuals

    Altered behavior and digestive outcomes in adult male rats primed with minimal colon pain as neonates

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    <p>Abstract</p> <p>Background</p> <p>Neonatal colon irritation (CI; pain or inflammation) given for 2 weeks prior to postnatal day 22 (PND22), causes long-lasting functional disorders in rats that can be seen 6 months after the initial insult. This study looked at the effect of varying the frequency and duration of neonatal CI on the rate of growth, digestive outcomes, exploratory activity, and colon and skin sensitivity in adult rats.</p> <p>Methods</p> <p>Male Sprague-Dawley rats were given CI using repeated colorectal distension (CRD) at different time intervals and for varying durations starting at PND 8, 10 or 14. Control rats were handled by the investigator without any intracolonic insertion. Further experiments were done on adult rats. Digestive outcomes (food and water consumption, fecal and urinary outputs) were measured using metabolic cages. Exploratory behavior was measured using digital video tracking in an open field. Cutaneous sensitivity was assessed by measuring the responses to mechanical and heat stimuli applied to the shaved abdomen or hind paws. Visceral sensitivity was measured by recording electromyographic responses, under light isoflurane anesthesia, from the external oblique muscles in response to CRD.</p> <p>Results</p> <p>No significant weight differences were observed between CI and control rats. Exploratory behavior was reduced in rats with neonatal CI compared to control. Digestive outputs and somatic and visceral sensitivity changed between different treatment groups with earlier and more frequent insults yielding a higher deviation from normal.</p> <p>Conclusion</p> <p>The diversity of behavioral and digestive symptoms in these rats parallels the diversity of symptoms in patients with functional gastrointestinal disorders and is consistent with global plastic changes affecting more than one system in the organism.</p

    The genetic determinants of recurrent somatic mutations in 43,693 blood genomes

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    Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine blood whole genomes from 37 cohorts and identified 7131 non-missense somatic mutations that are recurrently mutated in at least 50 individuals. These recurrent non-missense somatic mutations (RNMSMs) are not clearly explained by other clonal phenomena such as clonal hematopoiesis. RNMSM prevalence increased with age, with an average 50-year-old having 27 RNMSMs. Inherited germline variation associated with RNMSM acquisition. These variants were found in genes involved in adaptive immune function, proinflammatory cytokine production, and lymphoid lineage commitment. In addition, the presence of eight specific RNMSMs associated with blood cell traits at effect sizes comparable to Mendelian genetic mutations. Overall, we found that somatic mutations in blood are an unexpectedly common phenomenon with ancestry-specific determinants and human health consequences

    Activation of ground granulated blast furnace slag by using calcined dolomite

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    Both reactive MgO and CaO are alternative activators for ground granulated blast furnace slag (GGBS). In this study natural dolomite, as a source of MgO and CaO, was calcined at 800 °C (D800) and 1000 °C (D1000) in air. The activation of GGBS with the calcined dolomites was investigated using compressive tests, pH measurement of pore solutions, powder X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The results indicated that both calcined dolomites can effectively activate GGBS. D800 showed a relatively slower acceleration to GGBS than D1000 and both were slower than CaO. The use of D800 produced similar compressive strengths as did D1000 after 7 days curing but lower strengths at later ages. By increasing the dosage of activators, significantly higher strengths were obtained using D800 while only small increases were observed using D1000. The detected hydration products by XRD and TGA were mainly C–S–H and hydrotalcite-like phases, similar to those from other alkali-activated slags. The comparison to other activators indicated that using calcined dolomite can induce faster hydration of slag than using reactive MgO in the early age while slower than Portland cement in this study.The work presented in this paper was carried out at Department of Engineering, University of Cambridge, in the academic year 2012-2013 when the first author was a visiting researcher there. The visit was funded by the China Scholarship Council and the Scientific Research Foundation of the Graduate School of Nanjing University (No.2012CL11), which are greatly appreciated. The financial support for the PhD studentship of the second author from the Cambridge Trust and the China Scholarship Council is also much appreciated.This is the accepted manuscript version. The final version is available from Elsevier at http://www.sciencedirect.com/science/article/pii/S0950061814006631

    Quantum three-body system in D dimensions

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    The independent eigenstates of the total orbital angular momentum operators for a three-body system in an arbitrary D-dimensional space are presented by the method of group theory. The Schr\"{o}dinger equation is reduced to the generalized radial equations satisfied by the generalized radial functions with a given total orbital angular momentum denoted by a Young diagram [μ,ν,0,...,0][\mu,\nu,0,...,0] for the SO(D) group. Only three internal variables are involved in the functions and equations. The number of both the functions and the equations for the given angular momentum is finite and equal to (μν+1)(\mu-\nu+1).Comment: 16 pages, no figure, RevTex, Accepted by J. Math. Phy
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