11 research outputs found
キョケツ ハイ サイボウナイ ATP レベル テイカ ニトモナウ サイボウ ショウガイ ト カイメン カッセイ ブッシツ ブンピツノウ ノ ヘンカ キカンシ ハイホウ センジョウホウ ニヨル ヒョウカ
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A Patient with Non-alcoholic Steatohepatitis Complicated by Multiple Myeloma
Get PDFA 68-year-old woman with liver dysfunction was diagnosed with nonalcoholic steatohepatitis (NASH) stage 1. Three years later, she showed massive ascites and jaundice. A trans-jugular liver biopsy confirmed advanced cirrhosis, suggesting that her liver fibrosis had progressed rapidly. At the same time, she was diagnosed with multiple myeloma (MM). In this case, the plasma levels of osteopontin (OPN), a proinflammatory cytokine that promotes liver fibrosis progression through the hedgehog pathway and is increased in patients with MM, were increased. This increased OPN expression was accompanied by the upregulation of the hedgehog pathway in this patient, suggesting that the MM-associated increase in OPN had promoted the progression of liver fibrosis through the hedgehog pathway. The progression of liver fibrosis should be monitored in patients with NASH if other diseases, such as MM, are present
Prospective Multicenter Phase II Study of Myeloablative Conditioning of Iv Busulfan, Fludarabine +/− Low Dose TBI Intensified by G-CSF-Priming and Cytarabine for Myeloid Malignancies in Older Patients (≥55 Years): Final Analysis of the JSCT FB13 Study
No full textAdvantage of earlier thoracoscopic clipping of thoracic duct for post-operation chylothorax following thoracic aneurysm surgery
No full textcAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of the Period2 Gene
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