17 research outputs found
Mechanisms for the anti-obesity actions of bofutsushosan in high-fat diet-fed obese mice
White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice
Synergistic fungicidal efficacy of formulations of neem oil, nicotinic acid and Ferula asafoetida with .ALPHA., .BETA.-unsaturated carbonyl compounds against Sclerotium rolfsii ITCC 5226 & Macrophomina phaseolina ITCC 0482
Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity
Depot-specific effects of treadmill running and rutin on white adipose tissue function in diet-induced obese mice
Spleen-Derived Interleukin-10 Downregulates the Severity of High-Fat Diet-Induced Non-Alcoholic Fatty Pancreas Disease
Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes
Metabolic Syndrome Is Associated with Increased Oxo-Nitrative Stress and Asthma-Like Changes in Lungs
The nutrigenomic investigation of C57BL/6N mice fed a short-term high-fat diet highlights early changes in clock genes expression
Mice fed long-term high-fat diets (HFD) are an established model for human metabolic disorders, such as obesity and diabetes. However, also the effects of short-term HFD feeding should be investigated to understand which are the first events that trigger the onset of a pre-disease condition, the so-called metabolic syndrome, that increases the risk of developing clinical diseases. In this study, C57BL/6N mice were fed a control diet (CTR) or a HFD for 1 (T1) or 2 weeks (T2). Metabolic and histological effects were examined. Cecum transcriptomes of HFD and CTR mice were compared at T2 by microarray analysis. Differentially expressed genes were validated by real-time PCR in the cecum and in the liver. After 2 weeks of diet administration, HFD mice showed an altered expression pattern in only seven genes, four of which are involved in the circadian clock regulatory pathway. Real-time PCR confirmed microarray results of the cecum and revealed the same trend of clock gene expression changes in the liver. These findings suggest that clock genes may play an important role in early controlling gut output systems in response to HFD in mice and that their expression change may also represent an early signaling of the development of an intestinal pro-inflammatory status. \ua9 2013 Springer-Verlag Berlin Heidelberg