A CASE OF MULTIORGAN DYSFUNCTION DUE TO SCRUB TYPHUS INFECTION

Rickettsia tsutsugamushi causes an acute febrile illness known as scrub thypus. Humans get infected when they accidentally encroach the mite infested areas (mite islands) mainly in rural and sub-urban areas1. Scrub typhus is being increasingly reported in India. It should be considered in the differential diagnosis of patients with acute febrile illness, including those with thrombocytopenia, abnormalities in liver function tests, altered sensorium, atypical pneumonia, acute respiratory distress syndrome. We report a case Multi Organ Dysfunction due to scrub typhus infection. A thorough knowledge of scrub typhus including varied presentations and its complications is important for providing life saving treatment for patients

The example of CaPSURE: lessons learned from a national disease registry

IntroductionAlthough randomized controlled trials (RCTs) remain the gold standard for determining evidence-based clinical practices, large disease registries that enroll large numbers of patients have become paramount as a relatively cost-effective additional tool.MethodsWe highlight the advantages of disease registries focusing on the example of prostate cancer and the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE™) registry.ResultsCaPSURE collects approximately 1,000 clinical and patient-reported variables, in over 13,000 men that are enrolled. Thus far, CaPSURE has yielded over 130 peer-reviewed publications, with several others in press, in key areas of risk migration, practice patterns, outcome prediction, and quality of life outcomes.ConclusionsDisease registries, like CaPSURE complement RCTs and CaPSURE, have provided a means to better understand many aspects of prostate cancer epidemiology, practice patterns, oncologic and HRQOL outcomes, and costs of care across populations. Specialized observational disease registries such as CaPSURE provide insight and have broad implications for disease management and policy

Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: Direct evidence using electron spin resonance spectroscopy

10.1080/02713680490503723Current Eye Research286399-407CEYR