The role of extension in the Miocene denudation of the Nevado-Filábride Complex, Betic Cordillera (SE Spain)

The Internal Zone of the Betic Cordillera, SE Spain, consists of a nappe stack of three complexes, the deepest of which is the Nevado-Filábride Complex. The zone is separated from the overlying Alpujárride Complex by a crustal scale shear zone that has variously been interpreted as a thrust or an extensional detachment. A suite of 74 new apatite and zircon fission track results have been obtained from the Nevado-Filábride Complex and these have been used to define regional cooling patterns for the complex. Rapid cooling (105°C–200°C Ma−1) is spatially related to the tectonic contact with the overlying Alpujárride Complex-Cooling to near-surface temperatures occurred first in the east (Sierra de los Filabres) during the mid-Serravallian (12±1 Ma) and was completed by the early Tortonian (9–8 Ma) in the west (Sierra Nevada). There is no correlation between fission track age and sample elevation. These results are consistent with tectonic unroofing of this complex, a finding that favors extension as the mechanism by which the two complexes were brought into contact. Extension spans the middle and earliest upper Miocene (12–8 Ma) in the study area and therefore lasted much longer than previously documented. A hypothesis is advanced which links oblique convergence between the Iberian plate and the Betic Internal Zones, resulting in crustal contraction at depth, with orogen parallel extension in the middle and upper crust

The Input Signal Step Function (ISSF), a Standard Method to Encode Input Signals in SBML Models with Software Support, Applied to Circadian Clock Models

LetterThis is the final version of the article. Available from SAGE Publications via the DOI in this record.Time-dependent light input is an important feature of computational models of the circadian clock. However, publicly available models encoded in standard representations such as the Systems Biology Markup Language (SBML) either do not encode this input or use different mechanisms to do so, which hinders reproducibility of published results as well as model reuse. The authors describe here a numerically continuous function suitable for use in SBML for models of circadian rhythms forced by periodic light-dark cycles. The Input Signal Step Function (ISSF) is broadly applicable to encoding experimental manipulations, such as drug treatments, temperature changes, or inducible transgene expression, which may be transient, periodic, or mixed. It is highly configurable and is able to reproduce a wide range of waveforms. The authors have implemented this function in SBML and demonstrated its ability to modify the behavior of publicly available models to accurately reproduce published results. The implementation of ISSF allows standard simulation software to reproduce specialized circadian protocols, such as the phase-response curve. To facilitate the reuse of this function in public models, the authors have developed software to configure its behavior without any specialist knowledge of SBML. A community-standard approach to represent the inputs that entrain circadian clock models could particularly facilitate research in chronobiology.K.S. was supported by the UK BBSRC grant BB/E015263/1. SynthSys Edinburgh is a Centre for Integrative Systems Biology (CISB) funded by BBSRC and EPSRC, reference BB/D019621/1

A class of piecewise cubic interpolatory polynomials

A new class of C1 piecewise—cubic interpolatory polynomials is defined, by generalizing the definition of cubic X-splines given recently by Clenshaw and Negus (1978). It is shown that this new class contains a number of interpolatory functions which present practical advantages, when compared with the conventional cubic spline

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model

© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Prevention of transplant rejection can tolerance be achieved with immunosuppressive treatment?

Successful solid organ transplantation is generally attributed to the increasingly precise ability of drugs to control rejection. However, it was recently shown that a few donor haematolymphoid cells can survive for decades in recipients of successful organ allografts, a phenomenon called microchimaerism. The association for decades of haematolymphoid chimaerism with allograft tolerance in experimental transplantation suggests that immunosuppressive drugs merely create a milieu that enables an allograft and its complement of passenger leucocytes to prime the recipient for graft acceptance. Exploitation of this concept requires a fundamental shift in the classical view of passenger leucocytes only as initiators of rejection. Microchimaerism has taught us that solid organ transplantation involves the transfep-öTEwo3öTK}r organ systems to the recipient: the allograft parenchyma an-4oHg-4oonor'-4y&eWtolymphoid system in the form of donor stem cells contajfletwit|4Q(Xj pas-4MTger leucocyte compartment. Each has the potential to integral witty-4-4orrespSnping recipient system and carry out normal physiologi|:a£futy-4ijj£jvwlta5irnmunological self definition. Resistance to initial integralen r-4WMjure £als requires some form of immunosuppression, but mainterçad-4 of donor-4Rjraiine system function will depend on renewable supply of cells, v-4Jrf-4Siyi-4jj-4fvided by engrafted progenitors. Successful clinical application willctepcrrtTon the development of low morbidity methods to enhance engraftment of donor haemopoietic stem cells. Adis international Limited All rights reserved

Estimating labels from label proportions

Consider the following problem: given sets of unlabeled observations, each set with known label proportions, predict the labels of another set of observations, also with known label proportions. This problem appears in areas like e-commerce, spam filtering and improper content detection. We present consistent estimators which can reconstruct the correct labels with high probability in a uniform convergence sense. Experiments show that our method works well in practice.