43 research outputs found
Discovering universal statistical laws of complex networks
- Author
- A Arenas
- A Roxin
- A Wagner
- AE Motter
- AL Barabási
- BJ Prettejohn
- C Grabow
- C Zhan
- DJ Watts
- EA Leicht
- F Atay
- F Chung
- F Gerhard
- G Bianconi
- G Palla
- G Palla
- H Jeong
- H Jeong
- L Bogacz
- L Lovász
- L Zhao
- LEC Rocha
- LR Varshney
- M Boguñá
- M Kitsak
- M Rubinov
- ME Newman
- Moritz Deger
- O Sporns
- P Erdős
- P McGraw
- R Albert
- R Kötter
- R Milo
- R Milo
- R Milo
- R Tarjan
- Renaud Lambiotte
- S Jarvis
- Stefan Rotter
- Stefano Cardanobile
- T Mäki-Marttunen
- V Batagelj
- Volker Pernice
- W Chen
- X Wu
- Y Artzy-Randrup
- YY Liu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 15/12/2011
- Field of study
Different network models have been suggested for the topology underlying
complex interactions in natural systems. These models are aimed at replicating
specific statistical features encountered in real-world networks. However, it
is rarely considered to which degree the results obtained for one particular
network class can be extrapolated to real-world networks. We address this issue
by comparing different classical and more recently developed network models
with respect to their generalisation power, which we identify with large
structural variability and absence of constraints imposed by the construction
scheme. After having identified the most variable networks, we address the
issue of which constraints are common to all network classes and are thus
suitable candidates for being generic statistical laws of complex networks. In
fact, we find that generic, not model-related dependencies between different
network characteristics do exist. This allows, for instance, to infer global
features from local ones using regression models trained on networks with high
generalisation power. Our results confirm and extend previous findings
regarding the synchronisation properties of neural networks. Our method seems
especially relevant for large networks, which are difficult to map completely,
like the neural networks in the brain. The structure of such large networks
cannot be fully sampled with the present technology. Our approach provides a
method to estimate global properties of under-sampled networks with good
approximation. Finally, we demonstrate on three different data sets (C.
elegans' neuronal network, R. prowazekii's metabolic network, and a network of
synonyms extracted from Roget's Thesaurus) that real-world networks have
statistical relations compatible with those obtained using regression models
Recommended from our members
When do apples stop growing, and why does it matter?
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2021
- Field of study
Apples in the commercial food chain are harvested up to two weeks before maturity. We explore apple fruit development through the growing season to establish the point at which physical features differentiating those cultivars become evident. This is relevant both for the understanding of the growing process and to ensure that any identification and classification tools can be used both on ripened-on-tree and stored fruit. Current literature presents some contradictory findings on apple growth, we studied 12 apple cultivars in the Brogdale National Fruit Collection, UK over two seasons to establish patterns of growth. Fruit were sampled at regular time points throughout the growing season and four morphometrics (maximum length, maximum diameter, weight, and centroid size) were collected. These were regressed against growing degree days in order to appropriately describe the growth pattern observed. All four morphometrics were adequately described using log-log linear regressions, with adjusted R2 estimates ranging from 78.3% (maximum length) to 86.7% (weight). For all four morphometrics, a 10% increase in growing degree days was associated with a 1% increase in the morphometric. Our findings refine previous work presenting rapid early growth followed by a plateau in later stages of development and contrast with published expo-linear models. We established that apples harvested for commercial storage purposes, two weeks prior to maturity, showed only a modest decrease in size compared with ripened-on-tree fruit, demonstrating that size morphometric approaches are appropriate for classification of apple fruit at point of harvest
Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development
- Author
- A Bashamboo
- A Beleza-Meireles
- A Beleza-Meireles
- A Pearlman
- A Swain
- Abdullah Bereket
- AE Drummond
- AS Orekhova
- B Ferraz-de-Souza
- Berenice B Mendonca
- CK Matson
- D Bogani
- Dorien Baetens
- DT Gerrard
- E Krieger
- EF Pettersen
- Elfride De Baere
- F Coppieters
- F Coppieters
- Frank Peelman
- H Ostrer
- Hannah Verdin
- Hans Stoop
- I Del Valle
- J Loke
- JH Krege
- JH Segars
- JWR Schwabe
- K De Leeneer
- K Pettersson
- Karolien De Bosscher
- Katleen de Preter
- L-C Tranchevent
- Leendert H Looijenga
- LF Van der Zanden
- LFM Van der Zanden
- Lode De Cauwer
- M Asadi
- M Cools
- M Marino
- M Ono
- Malaïka Van der Linden
- Marnik Vuylsteke
- Martine Cools
- N Mongan
- N Warr
- Nathalia L Gomes
- NH Uhlenhaut
- PH Driggers
- R Guerois
- RM Baxter
- Ronald R de Krijger
- S Ban
- S Möcklinghoff
- S Richards
- Serap Turan
- Sorahia Domenice
- Tülay Güran
- Zeynep Atay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Purpose: Disorders or differences of sex development (DSDs) are rare congenital conditions characterized by atypical sex development. Despite advances in genomic technologies, the molecular cause remains unknown in 50% of cases.
Methods: Homozygosity mapping and whole-exome sequencing revealed an ESR2 variant in an individual with syndromic 46, XY DSD. Additional cases with 46, XY DSD underwent whole-exome sequencing and targeted next-generation sequencing of ESR2. Functional characterization of the identified variants included luciferase assays and protein structure analysis. Gonadal ESR2 expression was assessed in human embryonic data sets and immunostaining of estrogen receptor-beta (ER-beta) was performed in an 8-week-old human male embryo.
Results: We identified a homozygous ESR2 variant, c.541_543del p. (Asn181del), located in the highly conserved DNA-binding domain of ER-beta, in an individual with syndromic 46, XY DSD. Two additional heterozygous missense variants, c.251G>T p.(Gly84Val) and c.1277T>G p.(Leu426Arg), located in the N-terminus and the ligand-binding domain of ER-beta, were found in unrelated, nonsyndromic 46, XY DSD cases. Significantly increased transcriptional activation and an impact on protein conformation were shown for the p.(Asn181del) and p.(Leu426Arg) variants. Testicular ESR2 expression was previously documented and ER-beta immunostaining was positive in the developing intestine and eyes.
Conclusion: Our study supports a role for ESR2 as a novel candidate gene for 46, XY DSD
Homocysteine levels in women with a history of gestational diabetes mellitus
- Author
- AE Atay
- Aneta Fronczyk
- AR Folsom
- B Idzior-WaluÅ›
- C Catena
- C Kim
- C López-Tinoco
- C Xu
- CL Davis
- DS Feig
- EK Hoogeveen
- JB Meigs
- JM Lind
- JT Kielstein
- KL Schalinske
- Krzysztof Safranow
- L Bellamy
- Lilianna Majkowska
- M Buysschaert
- MA Guven
- MA Hoffman
- MN Munshi
- N Vitoratos
- NH Cho
- Piotr Molęda
- PM Catalano
- RJ Bosma
- S Alatab
- S Eichinger
- S Pushpakumar
- SA Schäfer
- X Zeng
- YM Smulders
- Z Asemi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Search for excited leptons in final states in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Acosta MV
- Adam W
- Adams MR
- Adams T
- Adzic P
- Afanasiev S
- Agapitos A
- Agaras MN
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Al-bataineh A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Aleksandrov A
- Alexakhin V
- Alexander J
- Ali MABM
- Alimena J
- Allen B
- Almond J
- Alvarez Fernandez A
- Alvarez JDR
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Ambrogi F
- Amendola C
- Amin N
- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Angioni GLP
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Apyan A
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arndt T
- Arneodo M
- Asavapibhop B
- Asawatangtrakuldee C
- Asilar E
- Askew A
- Atay S
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babaev A
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baffioni S
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Ball AH
- Ball F
- Ban Y
- Band R
- Banerjee S
- Banerjee S
- Bani L
- Bansal S
- Barbagli G
- Barberis E
- Barbieri R
- Bargassa P
- Baringer P
- Barker A
- Barnes VE
- Barney D
- Baron O
- Barone L
- Barria P
- Barrio Luna M
- Bartek R
- Barth C
- Bartok M
- Bartosik N
- Baselga M
- Baskakov A
- Bat A
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baur S
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerra DAS
- Beck L
- Beernaert K
- Beghin D
- Behera PK
- Behnke O
- Behrens U
- Bein S
- Beirao Da Cruz E Silva C
- Belchior Batista Das Chagas E
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Belyaev A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benelli G
- Beni N
- Benussi L
- Benvenuti AC
- Beretvas A
- Bergauer T
- Berger P
- Beri SB
- Bernardes CA
- Bernet C
- Berry D
- Berryhill J
- Bertl W
- Besancon M
- Beschi A
- Betts RR
- Bhandari R
- Bhardwaj A
- Bhardwaj R
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
- Bhattacharya S
- Bhawandeep U
- Bheesette S
- Bhopatkar V
- Bhowmik D
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- Bi R
- Bialkowska H
- Bian JG
- Bianchini L
- Bianco M
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- Biasini M
- Biino C
- Bilei GM
- Bilin B
- Bilki B
- Bin Anuar AA
- Bisello D
- Bitioukov S
- Blanco JM
- Blekman F
- Blinov V
- Blobel V
- Bloch D
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- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boletti A
- Bolla G
- Bonacorsi D
- Bondu O
- Boos E
- Boran F
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- Borgonovi L
- Bornheim A
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- Botta C
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- Brinkerhoff A
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- Brivio F
- Brochet S
- Brodski M
- Brom J-M
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- Brooke JJ
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- Butler JN
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- Butz E
- Bylinkin A
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- Cecchi C
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- Cenna F
- Cepeda M
- Cerati GB
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- Chaparro Sierra LF
- Chapon E
- Charaf O
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- Cifuentes JAB
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- Cussans D
- Cutts D
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- d'Enterria D
- D'Hondt J
- Da Costa EM
- Da Silveira GG
- Dabrowski A
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- Dalchenko M
- Dallavalle GM
- Damarseckin S
- Damgov J
- Damiani DD
- Danilov M
- Danilov V
- Daponte V
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- Dasgupta A
- Daskalakis G
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- de Cassagnac RG
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- De Guio F
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- de Monchenault GH
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- de Troconiz JF
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- Delaere C
- Delannoy AG
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- Delgado Peris A
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- Dell'Orso R
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- Della Porta GZ
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- Demiragli Z
- Demiroglu ZS
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- Devetak D
- Dewanjee RK
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- Di Marco E
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- Dishaw A
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- Gonzalez Caballero I
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- Gonzalez Hernandez CF
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- Gonzalez IDS
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- Hasegawa S
- Hashemi B
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- Hatakeyama K
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- Wu Z
- Wulsin HW
- Wulz C-E
- Wurthwein F
- Wyslouch B
- Xia F
- Xiao M
- Xiao R
- Xie S
- Xie W
- Xu Q
- Xu Z
- Yagil A
- Yalvac M
- Yang UK
- Yang YC
- Yates BR
- Yazgan E
- Yelton J
- Yetkin EA
- Yi K
- Yilmaz Y
- Yohay R
- Yonamine R
- Yoo HD
- Yoo J
- You C
- Yu D
- Yu GB
- Yu I
- Yu SS
- Yuan L
- Yumiceva F
- Yusli MN
- Zabel J
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zghiche A
- Zhang A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang Z
- Zhao J
- Zhaozhong S
- Zhokin A
- Zhu DH
- Zhu RY
- Zhukov V
- Zientek M
- Zito G
- Zobec J
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/04/2019
- Field of study
A search is presented for excited electrons and muons in ℓℓγ final states at the LHC. The search is based on a data sample corresponding to an integrated luminosity of 35.9 fb−1 of proton-proton collisions at a center-of-mass energy of 13 TeV, collected with the CMS detector in 2016. This is the first search for excited leptons at s√ = 13 TeV. The observation is consistent with the standard model background prediction, and the most stringent exclusion limits to date are set on the excited lepton mass and the compositeness scale, at 95% confidence level. Excited electrons and muons are excluded for masses below 3.9 and 3.8 TeV, respectively, under the assumption that the excited lepton mass equals the compositeness scale. The best observed limit on the compositeness scale is obtained with an excited lepton mass of around 1.0 TeV, excluding values below 25 TeV for both excited electrons and muons
Measurement of nuclear modification factors of ϒ(1S), ϒ(2S), and ϒ(3S) mesons in PbPb collisions at √sNN = 5.02 TeV
- Author
- Aarrestad TK
- Abad R
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
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- Zhang A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang Z
- Zhao J
- Zhokin A
- Zhu DH
- Zhu RY
- Zhukov V
- Zientek M
- Zito G
- Zobec J
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 10/03/2019
- Field of study
The cross sections for ϒ(1S), ϒ(2S), and ϒ(3S) production in lead–lead (PbPb) and proton–proton (pp)
collisions at √sNN = 5.02 TeV have been measured using the CMS detector at the LHC. The nuclear
modification factors, RAA, derived from the PbPb-to-pp ratio of yields for each state, are studied as
functions of meson rapidity and transverse momentum, as well as PbPb collision centrality. The yields of
all three states are found to be significantly suppressed, and compatible with a sequential ordering of the
suppression, RAA(Ï’(1S)) > RAA(Ï’(2S)) > RAA(Ï’(3S)). The suppression of Ï’(1S) is larger than that seen
at √sNN = 2.76 TeV, although the two are compatible within uncertainties. The upper limit on the RAA of
Ï’(3S) integrated over pT, rapidity and centrality is 0.096 at 95% confidence level, which is the strongest
suppression observed for a quarkonium state in heavy ion collisions to date
Measurement of prompt ψ(2S) production cross sections in proton–lead and proton–proton collisions at √sNN = 5.02 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Acosta MV
- Adam W
- Adams MR
- Adams T
- Adzic R
- Agapitos A
- Agaras MN
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmed I
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Al-bataineh A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aleksandrov A
- Alexander J
- Alexander T
- Ali MABM
- Alimena J
- Allen B
- Almond J
- Alvarez Fernandez A
- Alvarez JDR
- Alves FL
- Alves GA
- Alyari M
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- Ambrogi F
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- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
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- Angioni GLP
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- Wu Z
- Wulsin HW
- Wulz C-E
- Wurthwein F
- Wyslouch B
- Xia F
- Xiao M
- Xiao R
- Xie S
- Xie W
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- Xu Z
- Yagil A
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- Yang UK
- Yang YC
- Yates BR
- Yazgan E
- Yetkin EA
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- You C
- Yu D
- Yu GB
- Yu I
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- Yuan L
- Yuldashev BS
- Yumiceva F
- Yusli MN
- Zabel J
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zghiche A
- Zhang A
- Zhang F
- Zhang H
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- Zhang S
- Zhang Z
- Zhao J
- Zhaozhong S
- Zhiltsov V
- Zhokin A
- Zhu DH
- Zhu RY
- Zhukov V
- Zientek M
- Zito G
- Zobec J
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 10/03/2019
- Field of study
Measurements of prompt ψ(2S) meson production cross sections in proton–lead (pPb) and proton–proton
(pp) collisions at a nucleon–nucleon center-of-mass energy of √sNN = 5.02 TeV are reported. The results
are based on pPb and pp data collected by the CMS experiment at the LHC, corresponding to integrated
luminosities of 34.6 nb−1 and 28.0 pb−1, respectively. The nuclear modification factor RpPb is measured
for prompt ψ(2S) in the transverse momentum range 4 < pT < 30 GeV/c and the center-of-mass rapidity
range −2.4 < yCM < 1.93. The results on ψ(2S) RpPb are compared to the corresponding modification
factor for prompt J/ψ mesons. The results point to different nuclear effects at play in the production of
the excited charmonium state compared to the ground state, in the region of backward rapidity and for
pT < 10 GeV/c
Search for resonant tt¯ production in proton-proton collisions at s√=13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adam W
- Adams MR
- Adams T
- Adzic P
- Agapitos A
- Agaras MN
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Al-bataineh A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Ali MABM
- Alimena J
- Allen B
- Almond J
- Alvarez Fernandez A
- Alvarez JDR
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Ambrogi F
- Amendola C
- Amin N
- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Angioni GLP
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Apyan A
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arndt T
- Arneodo M
- Asavapibhop B
- Asawatangtrakuldee C
- Asilar E
- Askew A
- Atakisi IO
- Atay S
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
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- Wittmer B
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- Wolf R
- Wolfe E
- Womersley WJ
- Wong K
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- Woodard A
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- Wu Z
- Wulsin HW
- Wulz C-E
- Wurthwein F
- Wyslouch B
- Xia F
- Xiao M
- Xiao R
- Xie S
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- Xu Q
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- Yagil A
- Yalvac M
- Yang UK
- Yang YC
- Yates BR
- Yazgan E
- Yetkin EA
- Yilmaz Y
- Yohay R
- Yonamine R
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- Yoo J
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- Yu GB
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- Yuan L
- Yuldashev BS
- Yumiceva F
- Yusli MN
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zghiche A
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- Zou D
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 03/04/2019
- Field of study
A search for a heavy resonance decaying into a top quark and antiquark (tt¯) pair is performed using proton-proton collisions at s√=13 TeV. The search uses the data set collected with the CMS detector in 2016, which corresponds to an integrated luminosity of 35.9 fb−1. The analysis considers three exclusive final states and uses reconstruction techniques that are optimized for top quarks with high Lorentz boosts, which requires the use of nonisolated leptons and jet substructure techniques. No significant excess of events relative to the expected yield from standard model processes is observed. Upper limits on the production cross section of heavy resonances decaying to a tt¯ pair are calculated. Limits are derived for a leptophobic topcolor Z′ resonance with widths of 1, 10, and 30%, relative to the mass of the resonance, and exclude masses up to 3.80, 5.25, and 6.65 TeV, respectively. Kaluza-Klein excitations of the gluon in the Randall-Sundrum model are excluded up to 4.55 TeV. To date, these are the most stringent limits on tt¯ resonances
Urticaria and hydropneumothorax as an exceptional cause of ruptured hydatid cyst of lung
- Publication venue
- 'Medknow'
- Publication date
- 01/01/2013
- Field of study