662 research outputs found
The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia
Movement disorders in Parkinson’s disease (PD) are commonly associated with slow oscillations and increased synchrony of neuronal activity in the basal ganglia. The neural mechanisms underlying this dynamic network dysfunction, however, are only poorly understood. Here, we show that the strength of inhibitory inputs from striatum to globus pallidus external (GPe) is a key parameter controlling oscillations in the basal ganglia. Specifically, the increase in striatal activity observed in PD is sufficient to unleash the oscillations in the basal ganglia. This finding allows us to propose a unified explanation for different phenomena: absence of oscillation in the healthy state of the basal ganglia, oscillations in dopamine-depleted state and quenching of oscillations under deep-brain-stimulation (DBS). These novel insights help us to better understand and optimize the function of DBS protocols. Furthermore, studying the model behavior under transient increase of activity of the striatal neurons projecting to the indirect pathway, we are able to account for both motor impairment in PD patients and for reduced response inhibition in DBS implanted patients
Fitting Parton Distribution Data with Multiplicative Normalization Uncertainties
We consider the generic problem of performing a global fit to many
independent data sets each with a different overall multiplicative
normalization uncertainty. We show that the methods in common use to treat
multiplicative uncertainties lead to systematic biases. We develop a method
which is unbiased, based on a self--consistent iterative procedure. We
demonstrate the use of this method by applying it to the determination of
parton distribution functions with the NNPDF methodology, which uses a Monte
Carlo method for uncertainty estimation.Comment: 33 pages, 5 figures: published versio
Single spontaneous photon as a coherent beamsplitter for an atomic matterwave
In spontaneous emission an atom in an excited state undergoes a transition to
the ground state and emits a single photon. Associated with the emission is a
change of the atomic momentum due to photon recoil. Photon emission can be
modified close to surfaces and in cavities. For an ion, localized in front of a
mirror, coherence of the emitted resonance fluorescence has been reported. In
free space experiments demonstrated that spontaneous emission destroys motional
coherence. Here we report on motional coherence created by a single spontaneous
emission event close to a mirror surface. The coherence in the free atomic
motion is verified by atom interferometry. The photon can be regarded as a
beamsplitter for an atomic matterwave and consequently our experiment extends
the original recoiling slit Gedanken experiment by Einstein to the case where
the slit is in a robust coherent superposition of the two recoils associated
with the two paths of the quanta.Comment: main text: 5 pages, 4 figure; supplementary information: 8 pages, 1
figur
W boson production at hadron colliders: the lepton charge asymmetry in NNLO QCD
We consider the production of W bosons in hadron collisions, and the
subsequent leptonic decay W->lnu_l. We study the asymmetry between the rapidity
distributions of the charged leptons, and we present its computation up to the
next-to-next-to-leading order (NNLO) in QCD perturbation theory. Our
calculation includes the dependence on the lepton kinematical cuts that are
necessarily applied to select W-> lnu_l events in actual experimental analyses
at hadron colliders. We illustrate the main differences between the W and
lepton charge asymmetry, and we discuss their physical origin and the effect of
the QCD radiative corrections. We show detailed numerical results on the charge
asymmetry in ppbar collisions at the Tevatron, and we discuss the comparison
with some of the available data. Some illustrative results on the lepton charge
asymmetry in pp collisions at LHC energies are presented.Comment: 37 pages, 21 figure
Centre symmetric 3d effective actions for thermal SU(N) Yang-Mills from strong coupling series
We derive three-dimensional, Z(N)-symmetric effective actions in terms of
Polyakov loops by means of strong coupling expansions, starting from thermal
SU(N) Yang-Mills theory in four dimensions on the lattice. An earlier action in
the literature, corresponding to the (spatial) strong coupling limit, is thus
extended by several higher orders, as well as by additional interaction terms.
We provide analytic mappings between the couplings of the effective theory and
the parameters of the original thermal lattice theory, which can
be systematically improved. We then investigate the deconfinement transition
for the cases SU(2) and SU(3) by means of Monte Carlo simulations of the
effective theory. Our effective models correctly reproduce second order 3d
Ising and first order phase transitions, respectively. Furthermore, we
calculate the critical couplings and find agreement with
results from simulations of the 4d theory at the few percent level for
.Comment: 27 pages, 21 figures; final version published in JHEP; attached the
corresponding Erratum (ref. JHEP 1107:014,2011, DOI 10.1007/JHEP07(2011)014)
for ease of consultatio
Transiting extrasolar planetary candidates in the Galactic bulge
More than 200 extrasolar planets have been discovered around relatively
nearby stars, primarily through the Doppler line shifts owing to the reflex
motions of their host stars, and more recently through transits of some planets
across the face of the host stars. The detection of planets with the shortest
known periods, 1.2 to 2.5 days, has mainly resulted from transit surveys which
have generally targeted stars more massive than 0.75 M_sun. Here we report the
results from a planetary transit search performed in a rich stellar field
towards the Galactic bulge. We discovered 16 candidates with orbital periods
between 0.4 and 4.2 days, five of which orbit stars of 0.44 to 0.75 M_sun. In
two cases, radial-velocity measurements support the planetary nature of the
companions. Five candidates have orbital periods below 1.0 day, constituting a
new class of ultra-short-period planets (USPPs), which occur only around stars
of less than 0.88 M_sun. This indicates that those orbiting very close to more
luminous stars might be evaporatively destroyed, or that jovian planets around
lower-mass stars might migrate to smaller radii.Comment: To appear in October 5, 2006 issue of Natur
Automation of one-loop QCD corrections
We present the complete automation of the computation of one-loop QCD
corrections, including UV renormalization, to an arbitrary scattering process
in the Standard Model. This is achieved by embedding the OPP integrand
reduction technique, as implemented in CutTools, into the MadGraph framework.
By interfacing the tool so constructed, which we dub MadLoop, with MadFKS, the
fully automatic computation of any infrared-safe observable at the
next-to-leading order in QCD is attained. We demonstrate the flexibility and
the reach of our method by calculating the production rates for a variety of
processes at the 7 TeV LHC.Comment: 64 pages, 12 figures. Corrected the value of m_Z in table 1. In table
2, corrected the values of cross sections in a.4 and a.5 (previously computed
with mu=mtop/2 rather than mu=mtop/4). In table 2, corrected the values of
NLO cross sections in b.3, b.6, c.3, and e.7 (the symmetry factor for a few
virtual channels was incorrect). In sect. A.4.3, the labeling of the
four-momenta was incorrec
A comparison of diagnostic tests for lactose malabsorption - which one is the best?
<p>Abstract</p> <p>Background</p> <p>Perceived milk intolerance is a common complaint, and tests for lactose malabsorption (LM) are unreliable. This study assesses the agreement between diagnostic tests for LM and describes the diagnostic properties of the tests.</p> <p>Methods</p> <p>Patients above 18 years of age with suspected LM were included. After oral intake of 25 g lactose, a combined test with measurement of serum glucose (s-glucose) and hydrogen (H2) and methane (CH4) in expired air was performed and symptoms were recorded. In patients with discrepancies between the results, the combined test was repeated and a gene test for lactose non-persistence was added. The diagnosis of LM was based on an evaluation of all tests. The following tests were compared: Increase in H2, CH4, H2+CH4 and H2+CH4x2 in expired air, increase in s-glucose, and symptoms. The agreement was calculated and the diagnostic properties described.</p> <p>Results</p> <p>Sixty patients were included, seven (12%) had LM. The agreement (kappa-values) between the methods varied from 0.25 to 0.91. The best test was the lactose breath test with measurement of the increase in H2 + CH4x2 in expired air. With a cut-off level < 18 ppm, the area under the ROC-curve was 0.967 and sensitivity was 100%. This shows that measurement of CH4 in addition to H2 improves the diagnostic properties of the breath test.</p> <p>Conclusion</p> <p>The agreement between commonly used methods for the diagnosis of LM was unsatisfactory. A lactose breath test with measurement of H2 + CH4x2 in expired air had the best diagnostic properties.</p
Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomide
Determinants of Habitat Selection by Hatchling Australian Freshwater Crocodiles
Animals almost always use habitats non-randomly, but the costs and benefits of using specific habitat types remain unknown for many types of organisms. In a large lake in northwestern Australia (Lake Argyle), most hatchling (<12-month-old) freshwater crocodiles (Crocodylus johnstoni) are found in floating vegetation mats or grassy banks rather than the more widely available open banks. Mean body sizes of young crocodiles did not differ among the three habitat types. We tested four potential explanations for non-random habitat selection: proximity to nesting sites, thermal conditions, food availability, and exposure to predation. The three alternative habitat types did not differ in proximity to nesting sites, or in thermal conditions. Habitats with higher food availability harboured more hatchlings, and feeding rates (obtained by stomach-flushing of recently-captured crocodiles) were highest in such areas. Predation risk may also differ among habitats: we were twice as likely to capture a crocodile after seeing it in open-bank sites than in the other two habitat types. Thus, habitat selection of hatchling crocodiles in this system may be driven both by prey availability and by predation risk
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