8 research outputs found
Linear rheology of bituminous mastics modified with various polyolefins: a comparative study with their source binders
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Segmented inner plexiform layer thickness as a potential biomarker to evaluate open-angle glaucoma: Dendritic degeneration of retinal ganglion cell
- Author
- AC Nuschke
- AD Huberman
- AL Moura
- AS Raza
- BJ Frankfort
- C Dysli
- C Mayama
- Chan Kee Park
- D Su
- DC Hood
- DC Hood
- DC Hood
- DF Garway-Heath
- Eun Kyoung Kim
- H Wassle
- Hae-Young Lopilly Park
- HL Rao
- HY Shin
- J Agostinone
- JA Hanley
- JC Mwanza
- JE Morgan
- JH Choi
- JL Wheat
- JM Martinez-de-la-Casa
- JP Campbell
- L Della Santina
- M Greschner
- M Wang
- O Tan
- R Zeimer
- RH Berry
- RH Masland
- RN El-Danaf
- Sanjoy Bhattacharya
- WG Jacoby
- ZW Li
- ZZ Bao
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Implementation Research to Inform the Use of Xpert MTB/RIF in Primary Health Care Facilities in High TB and HIV Settings in Resource Constrained Settings
- Author
- A Van Rie
- AD Harries
- Albertus Schaap
- AM Elliott
- B van Ginneken
- CF Hanrahan
- CM Parry
- CP Hudson
- D Zachary
- Deborah Milimo
- G Theron
- G Theron
- G Theron
- GM Cohen
- H Getahun
- H Muto
- HC Mwandumba
- Helen Ayles
- HL Rieder
- L Hogeweg
- LG Naul
- M Muyoyeta
- Mapopa Ndhlovu
- Matthew P Fox
- Maureen Moyo
- Monde Muyoyeta
- Nathan Kapata
- NJ Hargreaves
- Nkatya Kasese
- P Maduskar
- Pamela Nabeta Catharina C Boehme
- Peter Godfrey Faussett
- PF Barnes
- R Colebunders
- RO Duda
- S Jaeger
- S Naidoo
- SD Lawn
- SD Lawn
- THAH van
- Winfridah Mwanza
- Y Arzhaeva
- Y Kurihara
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Incidence of Natural Ectomycorrhizal Infection of Pine and Eucalypt Seedlings in Three KwaZulu-Natal Nurseries
- Author
- AMARANTHUS M. P.
- BOWEN G. D.
- CARLSON C. A.
- CHU-CHOU M.
- CROGHAN C. F.
- DODD J. C.
- DONALD D. G. M.
- DONALD D. G. M.
- DONALD D. G. M.
- DONALD D. G. M.
- FRANCIS R.
- HARLEY J. L.
- HODGSON R. J.
- KENERLEY C. M.
- LAMB R. J.
- MALAJCZUK N.
- MARX D. H.
- MCAFEE B. J.
- MIKOLA P.
- MWANZA E. J. M.
- NOBLE AD.
- RELIHAN M. D.
- ROSADO S. C. S.
- SMITH S. S. E.
- SMITH W. G.
- TOSH J. E.
- TRAPPE J. M.
- VAN DER WESTHUIZEN G. C. A.
- VANGREUNING J. V.
- VILJOEN A.
- WOLSTENHOLME B. N.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Divergence of dim-light vision among bats (order: Chiroptera) as estimated by molecular and electrophysiological methods
- Author
- A Kasus-Jacobi
- A Nystuen
- AC Silva
- AD Melin
- AM Geller
- B Li
- B Young
- BB Thomas
- CH Sung
- CJR Loewen
- D Baylor
- D Bissig
- DG Luo
- DJ Stark
- DR Moore
- DR Moore
- E Warrant
- EJ Warrant
- G Dennis Jr.
- J Chase
- J Eklöf
- J Gao
- J Kusch
- J Siegel
- J Zheng
- JC Mwanza
- JD Pettigrew
- JJ Scott-McKean
- JK Bowmaker
- JR Speakman
- KP Hoffmann
- KW Yau
- KYYaWL Ruzzo
- MA Kraut
- MF Jay
- MG Grabherr
- NB Simmons
- O Szabo-Salfay
- P Reinagel
- PH Schiller
- R Suthers
- RP Kalesnykas
- RT Marrocco
- S Yokoyama
- SJ Bowne
- T Furukawa
- T Meigen
- T Pizzorusso
- T Yamashita
- TA Berninger
- TD Lamb
- TS Kim
- V Porciatti
- W Li
- Y Li
- Y Liu
- Y Saito
- YY Shen
- YY Shen
- YY Shen
- YY Shen
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Computer Vision Techniques Applied for Diagnostic Analysis of Retinal OCT Images: A Review
- Author
- A Al-Mujaini
- A Iwase
- A Mariampillai
- A Pachiyappan
- A Szkulmowska
- AD Fleming
- AFHC Fercher
- AM Bron
- B Bouma
- B Golubovic
- B Potsaid
- B PovaĆŸay
- BJ Curtin
- BJ Curtin
- BJ Curtin
- BJ Curtin
- BR Biedermann
- C Bowd
- C Day
- C Fox
- C Jun
- CA Puliafito
- CF Burgoyne
- D Huang
- DJ Browning
- E Lebed
- G Pardianto
- GR Wilkins
- H Cho
- HA Quigley
- HA Quigley
- HE Jelinek
- I Grulkowski
- I Maruko
- IA Sigal
- IA Sigal
- II Bussel
- IV Larina
- J Shaw
- J Vongphanit
- J Xu
- J Xu
- J-C Mwanza
- JE Shaw
- JG Fujimoto
- JJ Kanski
- JL Keltner
- JS Green
- JS Schuman
- K Hayashi
- K Ohno-Matsui
- K Ohno-Matsui
- L Kyungmoo
- L Sieun
- L Yu
- LM Jampol
- LS Lim
- M Choma
- M Miura
- M Moriyama
- M Wojtkowski
- M Wojtkowski
- M Wojtkowski
- M Young
- MA Choma
- MD Abramoff
- MD AbrĂ moff
- MMK Muqit
- MR Hee
- Muhammad Moazam Fraz
- Muhammad Usman
- N Nassif
- NA McBrien
- PJ Foster
- QD Nguyen
- R Huber
- R Huber
- R Huber
- R Huber
- R Liang
- R Poddar
- R Raman
- R Thomas
- RA Kowluru
- RK Wang
- Ronnie M George
- S Wild
- S Yun
- S Yun
- S-W Huang
- SA Cotter
- Sarah A. Barman
- SC Park
- SH Yun
- SY Shen
- T Bajraszewski
- T Iwasaki
- T Josifova
- The Eye Diseases Prevalence Research G
- W Drexler
- WY Oh
- WY Oh
- Y Imamura
- Z Hu
- Z Yaqoob
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Rhesus Macaque Model of Chronic Opiate Dependence and Neuro-AIDS: Longitudinal Assessment of Auditory Brainstem Responses and Visual Evoked Potentials
- Author
- A Beaufoy
- A Ciardi
- A Krol
- A Mahadevan
- AA Ansari
- AD Legatt
- AR Moller
- AR Moller
- AR Moller
- AR Moller
- AR Moller
- AR Moller
- BM Sharp
- CK Petito
- DP Sharma
- DW Scott
- E Castello
- EA Murray
- Emily Ledford
- F Kapadia
- F Kirchhoff
- F Pierelli
- FH Bouwman
- Frank K. Samson
- G Alkhatib
- G Curio
- G Farnarier
- GS Tomlinson
- H Bacellar
- H Deng
- H Gayle
- Himanshu Kenjale
- I Everall
- I Hashimoto
- I Hashimoto
- IA Binswanger
- IJ Koralnik
- IJ Spijkerman
- IJ Spijkerman
- IJ Spijkerman
- IP Everall
- Istvan Adany
- J Davies
- Janet Marquis
- JC Arrango
- JC McArthur
- JC McArthur
- JC Mwanza
- JD Glass
- JE Bell
- JE Bell
- JK Marcario
- JK Marcario
- JK Marcario
- JK Marcario
- JL Chen
- Joanne K. Marcario
- JS Buchwald
- JV Bruckner
- L McCarthy
- LA Raymond
- LA Raymond
- LA Raymond
- LE Thorpe
- LF Chuang
- LH Gold
- M Prins
- MA Kraut
- MA Pagano
- Mariam Riazi
- MC Barr
- MC Barr
- MD Kanzer
- MH Seevers
- MJ Sepulveda
- MR Weed
- NE Berman
- O Narayan
- O Prospero-Garcia
- OJ Manzoni
- Opendra Narayan
- P Alcabes
- P Pezzotti
- PA Marx
- PA Selwyn
- Paul D. Cheney
- PH Hoeger
- PM Lalley
- PN Fultz
- R Hausler
- R Kumar
- R Malessa
- R Raghavan
- RF Ghaly
- RF Ghaly
- RM Donahoe
- RM Donahoe
- RS Veazey
- RS Veazey
- RS Veazey
- RW Price
- S Roy
- S Suzuki
- SA Lipton
- SA Lipton
- SJ Hutchinson
- T Dragic
- T Thorlin
- TE Callahan
- TF Horn
- TS Diesing
- Vincent Staggs
- VJ Iragui
- Z Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
- Azar M
- Azbel L
- Azizuyo B
- Babiker A
- Babikhina K
- Back D
- Badjé A
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baggaley R
- Baghazal A
- Bagley Z
- Bah-sow O
- Baijnath P
- Bailey R
- Bailey R
- Bajos N
- Bajracharya A
- Bajunirwe F
- Bakowska E
- Bakwalufu J
- Balestre E
- Balkan S
- Balzer L
- Bamba A
- Banda G
- Banda K
- Bandason T
- Bangsberg
- Baral S
- Baral S
- Baral S
- Baral S
- Baral S
- Barasa M
- Barber M
- Barbour R
- Barde A
- Bardeguez A
- Barihuta T
- Barker C
- Barnabas R
- Barnes P
- Barnighausen T
- Baron D
- Barone M
- Barr D
- Barrenas C
- Barrington C
- Barron P
- Baruwa E
- Basar M
- Bassett I
- Bassett J
- Bassett J
- Bastos F
- Batrouney C
- Bauer G
- Baum M
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bavinton B
- Bavinton B
- Baxter C
- Baya J
- Bazin B
- Bañón S
- Beauchamp G
- Beauchamp G
- Beck G
- Beckham S
- Bedi K
- Bekker L-G
- Beletsky L
- Belkind U
- Bell J
- Belloso W
- Belonosova E
- Belzer M
- Benedetti M
- Benfield T
- Bennett K
- Bennett K
- Bennett K
- Benson S
- Bere A
- Berkhout B
- Bermudez LG
- Bernard E
- Bernardo V
- Bernaud C
- Bertrand S
- Bhagani
- Bhardwaj K
- Bhardwaj S
- Bhardwaj S
- Bhayani L
- Bi G
- Biello K
- Biello K
- Bii S
- Bilkovski R
- Binda K
- Binley J
- Bisht M
- Bisignano A
- Bivol S
- Black D
- Blantari J
- Blick G
- Blumenthal S
- Bock N
- Boivin M
- Boleo C
- Boleo C
- Bolton-Moore C
- Bond V
- Bonnecwe C
- Bonnington O
- Bonnington O
- Bonzela J
- Boonsuk S
- Bor J
- Bor J
- Bor J
- Bor J
- Bor J
- Bor J
- Borkird T
- Borquez A
- Bose M
- Bosomprah S
- Bouchaud O
- Boulle A
- Boum Y
- Bouzas M
- Bowman B
- Boyd A
- Boyd R
- Boyer S
- Boyer S
- Boyes M
- Bozinoff N
- Bozzi G
- Bradley J
- Brahmbhatt H
- Brainard D
- Brand R
- Bredeek U
- Brenchley J
- Brennan A
- Brennan A
- Brennan A
- Brennan C
- Brennan D
- Brewster-Lee D
- Brezak A
- Brigham F
- Brigstock-Barron O
- Brill I
- Brill I
- Brittain K
- Britto P
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brooks R
- Brooks-Pollock E
- Brothers J
- Brotto L
- Brouwers P
- Brown E
- Brown G
- Brown H
- Brown L
- Browning R
- Browning R
- Brummel S
- Brummel S
- Bryant H
- Bryant K
- BrÀu N
- Bucek A
- Bucek A
- Buchanan A
- Buehler S
- Bukenya D
- Bukenya D
- Bukenya D
- Bukowski L
- Bukowski L
- Bukusi D
- Bukusi E
- Bukusi E
- Bukusi E
- Bukusi E
- Bukusi E
- Bulterys M
- Bulya N
- Bulya N
- Bunu A
- Burchett S
- Burgener A
- Burke S
- Burman W
- Burmeister S
- Burton R
- Burwitz B
- Busch M
- Busch M
- Busza J
- Bwakura-Dangarembizi M
- Bwakura-Dangarembizi M
- Bwana M
- Bygrave H
- Byrareddy S
- Byrd J
- Byrne E
- BĂ€rnighausen T
- BĂ€rnighausen T
- Cadigan J
- Cahn P
- Cahn P
- Cai F
- Cai Y
- Cale E
- Cambiano V
- Cameron D
- Cameron P
- Campa A
- Campbell
- Campbell T
- Candrinho B
- Capitant C
- Capitant C
- Caraulan L
- Cardenas-Ochoa A
- Cardoso J
- Carias A
- Carlson J
- Carmona S
- Carmona S
- Carmona S
- Carmona S
- Carneiro P
- Carnimeo V
- Carolus G
- Carrasco M
- Carrington M
- Carroll R
- Carter A
- Casado J
- Casavant I
- Cassell M
- Castellanos E
- Castelnuovo B
- Cathcart R
- Catranji V
- Cattamanchi A
- Cawley C
- Cawley C
- Cawood C
- Cawood C
- Cawood C
- Cazein F
- Cecchini D
- Cecilio M
- Celum C
- Celum C
- Celum C
- Celum C
- Ceranto A
- Chabala C
- Chabata S
- Chabeda S
- Chakhtoura N
- Chakhtoura N
- Chakhtoura N
- Chamanga R
- Chamie G
- Chanaiwa V
- Chandawale A
- Chandra C
- Chandra S
- Chang E
- Chang M
- Chang W
- Changalucha J
- Chapman S
- Chappell E
- Charlebois E
- Charlebois E
- Charlebois E
- Charlebois E
- Charoenying S
- Charreau I
- Charreau I
- Chas J
- Chas J
- Chasanov
- Chaturvedi S
- Chaudhury S
- Chege W
- Chelbi-Alix M
- Chemhuru M
- Chen C-H
- Chen L
- Chen M
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng H
- Cheng Z
- Cheu R
- Chidiac C
- Chigayo M
- Chihana NK
- Chikandiwa A
- Chikandiwa A
- Chikonda J
- Chileshe C
- Chilima B
- Chilima B
- Chilongani J
- Chimanpure V
- Chimbetete C
- Chimbetete C
- Chime C
- Chinkonde J
- Chinsinga B
- Chipadze
- Chipeta Z
- Chipungu J
- Chirchir B
- Chirowodza A
- Chirwa E
- Chirwa E
- Chirwa Z
- Chiyaka T
- Chomba E
- Chomba E
- Chomchey N
- Chomont N
- Chomont N
- Chopera D
- Chung A
- Church K
- Church K
- Cianci G
- Cicala C
- Clark T
- Clark T
- Clark T
- Clarke A
- Clarke K
- Clotet B
- Cluver L
- Cluver L
- Coffey-Esquivel J
- Cofield S
- Cohen
- Cohen C
- Cohen C
- Cohen C
- Cohen K
- Cohort S
- Cole M
- Colebunders R
- Coletti A
- Coletti A
- Collins I
- Collins S
- Colua E
- Come J
- Comstock L
- Condo J
- Contreras D
- Contreras-Loya D
- Conway D
- Cook A
- Coombs J-A
- Coombs R
- Cooper D
- Cooper D
- Cooper K
- Copas A
- Corbelli G
- Corey L
- Coris
- Corrigan B
- Cossa L
- Costagliola D
- Costiniuk C
- Cotte L
- Couderc C
- Coulibaly A
- Coulter R
- Cowan F
- Cowan F
- Cowan F
- Crampin A
- Crandall B
- Cranston R
- Crauwels H
- Crooks E
- Crosno K
- Crouch P-C
- Cua E
- Cuembelo F
- Cummins N
- Curran K
- Currier J
- Currier J
- Curtis P
- Custer B
- Czaicki N
- D'Angelo L
- D'Aquila R
- Dabis F
- Daho S
- Dalal S
- Dam K
- Danboise B
- Danel C
- Dange A
- Daniel C
- Daniels B
- Darbes L
- Darong G
- Darr E
- Daskalakis D
- Daskilewicz K
- Datong P
- Davenport M
- Davey C
- Davey DJ
- Davies M-A
- Davies N
- Davis S
- Davis VR
- Davis W
- Dawood H
- Dawood H
- Dawson L
- Dayton F
- Ddaaki W
- Ddaaki W
- Ddaaki W
- De Castro D
- De Gruttola V
- De Jong B
- de la Grecca R
- de Lima Pereira ME
- de Lima CE
- de Oliveira T
- De Oliveira T
- de Pedro A
- de Pokomandy A
- de Roubaix M
- de Schacht C
- de Souza M
- de Souza MB
- de Vries H
- Decker M
- Decroo T
- del Amo J
- Del Prete G
- Delany-Moretlwe S
- Delany-Moretlwe S
- Delany-Moretlwe S
- Delany-Moretlwe S
- Delate R
- Delaugerre C
- Delfraissy J-F
- Dellar R
- Demeri D
- Denny T
- Desbiens M
- Deuba K
- Devieux J
- Dewar R
- Deyde V
- Dezembro S
- Dezutti C
- Dhilpe V
- Dhodho M
- Di Giano L
- Dias PG
- Diergaardt C
- Diez-Martin J
- Dikgale F
- Dikobe W
- Dimba A
- Dinanga JD
- Dinapoli S
- Dindi P
- Dindi P
- Ding E
- Diop A
- Diouf D
- DiPaola A
- Dirawo J
- Diseko M
- Dlamini D
- Doehle B
- Doerholt K
- Doherty T
- Dolezal C
- Dolezal C
- Donaldson E
- Donastorg Y
- Doncel G
- Dong K
- Dong K
- Donnell D
- Donnelly A
- Dores CD
- Dorey D
- Doria-Rose N
- Dorvil N
- Doré V
- Dos Santos N
- Dougherty G
- Dow W
- Dowdy D
- Dowsett G
- Drain P
- Drame F
- Dray-Spira R
- Dreyer J
- Dronda F
- du Lou AD
- Dube F
- Dube K
- Dube K
- Dube M
- Dubuc D
- Duby Z
- Dubé K
- Duck T
- Duerr A
- Duffill K
- Dumont E
- Dunkle K
- Dunn D
- Dunsmore T
- Dunsmore T
- Durand-Zaleski I
- Dutrieux J
- Dutta A
- Duverger L
- Dvoriak S
- Dzekedzeke K
- Dzissyuk N
- Dzoro S
- DĂaz A
- Eba P
- Ebagua I
- Eckard M
- Ecochard R
- Edelstein H
- Edick S
- Egan D
- Egan J
- Ehmer J
- Ehmer J
- Eholié S
- Ehouman S
- Ehrenkranz P
- Ekong E
- Ekström A
- El-Sadr W
- El-Sadr W
- Eley B
- Elkington K
- Elkington K
- Eller L
- Ellman T
- Ellman T
- Ellman T
- Ellman T
- Else L
- Emel L
- Emel L
- Emery S
- Emusu D
- Engstrom J
- Erekaha S
- Ericsen A
- Ernest O
- Eshleman S
- Esiru G
- Essex M
- Essex M
- Essex M
- Estes J
- Estes J
- Etard J-F
- Etard J-F
- Etima J
- Etyang T
- Eubanks K
- Evans D
- Evans D
- Evans M
- Evans-Frantz I
- Ezouatchi R
- Faden R
- Fagan T
- Fahey C
- Fair C
- Fairley C
- FalcĂł V
- Familiar I
- Fantus S
- Farley S
- Farley T
- Farquhar C
- Fast D
- Fatti G
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated