9 research outputs found
Modelling urban populations of the Australian White Ibis (Threskiornis molucca) to inform management
Since the 1970s, populations of the Australian White Ibis (Threskiornis molucca) have dramatically increased in many Australian urban centres. Managers of ibis are currently focusing on limiting this bird's reproductive success in order to reduce population sizes or at least halt further increases in urban areas. Here we use data on nesting success and survival for three populations of ibis around greater Sydney to develop an age-structured population model. The estimated growth rate for all populations combined was about 1.5 % per year and for individual sites were more variable at -1, -7, and 9 %. For all populations, growth rates were most sensitive (based on elasticity analyses) to the survival of adults and least sensitive to fecundity, especially of 3 year olds. Further exploration of the importance of fecundity rates, which are relatively poorly known for these populations, suggests that rates of 0.7 fledgling per nest per year. The results suggest that ibis from other locations (probably their traditional breeding areas in inland Australia) have immigrated into urban environments as estimated growth rates cannot account for current population sizes. Management strategies must take these findings into account and also consider that ibis are declining in their traditional habitats to avoid exacerbating their decline at a regional scale. © 2013 The Society of Population Ecology and Springer Japan
Identification of a New Hormone-Binding Site on the Surface of Thyroid Hormone Receptor
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily of ligand-activated transcription factors involved in cell differentiation, growth, and homeostasis. Although X-ray structures of many nuclear receptor ligand-binding domains (LBDs) reveal that the ligand binds within the hydrophobic core of the ligand-binding pocket, a few studies suggest the possibility of ligands binding to other sites. Here, we report a new x-ray crystallographic structure of TR-LBD that shows a second binding site for T-3 and T-4 located between H9, H10, and H11 of the TR alpha LBD surface. Statistical multiple sequence analysis, site-directed mutagenesis, and cell transactivation assays indicate that residues of the second binding site could be important for the TR function. We also conducted molecular dynamics simulations to investigate ligand mobility and ligand-protein interaction for T-3 and T-4 bound to this new TR surface-binding site. Extensive molecular dynamics simulations designed to compute ligand-protein dissociation constant indicate that the binding affinities to this surface site are of the order of the plasma and intracellular concentrations of the thyroid hormones, suggesting that ligands may bind to this new binding site under physiological conditions. Therefore, the second binding site could be useful as a new target site for drug design and could modulate selectively TR functions.o TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.284534545Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP [2010/17048-8, 2013/08293-7
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Six transiting planets and a chain of Laplace resonances in TOI-178
Determining the architecture of multi-planetary systems is one of the
cornerstones of understanding planet formation and evolution. Resonant systems
are especially important as the fragility of their orbital configuration
ensures that no significant scattering or collisional event has taken place
since the earliest formation phase when the parent protoplanetary disc was
still present. In this context, TOI-178 has been the subject of particular
attention since the first TESS observations hinted at a 2:3:3 resonant chain.
Here we report the results of observations from CHEOPS, ESPRESSO, NGTS, and
SPECULOOS with the aim of deciphering the peculiar orbital architecture of the
system. We show that TOI-178 harbours at least six planets in the super-Earth
to mini-Neptune regimes, with radii ranging from 1.152(-0.070/+0.073) to
2.87(-0.13/+0.14) Earth radii and periods of 1.91, 3.24, 6.56, 9.96, 15.23, and
20.71 days. All planets but the innermost one form a 2:4:6:9:12 chain of
Laplace resonances, and the planetary densities show important variations from
planet to planet, jumping from 1.02(+0.28/-0.23) to 0.177(+0.055/-0.061) times
the Earth's density between planets c and d. Using Bayesian interior structure
retrieval models, we show that the amount of gas in the planets does not vary
in a monotonous way, contrary to what one would expect from simple formation
and evolution models and unlike other known systems in a chain of Laplace
resonances. The brightness of TOI-178 allows for a precise characterisation of
its orbital architecture as well as of the physical nature of the six presently
known transiting planets it harbours. The peculiar orbital configuration and
the diversity in average density among the planets in the system will enable
the study of interior planetary structures and atmospheric evolution, providing
important clues on the formation of super-Earths and mini-Neptunes