7 research outputs found
Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base
Considering the importance of metal complexes in the development of
medical science, two different Schiff base Fe(II) and Co(II) metal
complex compounds were synthesized with Schiff base obtained through the
condensation of 1-(4-aminophenyl)ethanone with
2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II)
and Fe(II) metal ions enabled six coordination compounds with octahedral
geometries. The novel metal complexes were characterized by IR,
elemental analyses, magnetic susceptibility, mass spectra, UV-Vis,
thermogravimetry-differential thermal analysis (TGA-DTA) and X-ray
diffraction analysis. The antioxidant properties of the new compounds
were investigated using different in vitro assays. Moreover, enzyme
inhibition of derivatives complexes against carbonic anhydrase I and II
isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated.
The best inhibitor complex for CA I and II isoenzymes was the Fe(II)
complex with K-i values of 52.83 +/- 11.52 and 63.34 +/- 8.88,
respectively