18 research outputs found
Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue
No full textMechanical stresses in carotid plaques using MRI-based fluid–structure interaction models
No full textSensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides
No full textInfluence of free volumes on functional properties of modified chalcogenide glasses and oxide ceramics
No full textInternational audienc
Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening
No full textNucleobase-Modified Triplex-Forming Peptide Nucleic Acids for Sequence-Specific Recognition of Double-Stranded RNA
No full textBecause of the important roles noncoding RNAs play in gene expression, their sequence-specific recognition is important for both fundamental science and the pharmaceutical industry. However, most noncoding RNAs fold in complex helical structures that are challenging problems for molecular recognition. Herein, we describe a method for sequence-specific recognition of double-stranded RNA using peptide nucleic acids (PNAs) that form triple helices in the major grove of RNA under physiologically relevant conditions. We also outline methods for solid-phase conjugation of PNA with cell-penetrating peptides and fluorescent dyes. Protocols for PNA preparation and binding studies using isothermal titration calorimetry are described in detail
Whole-Pattern Fitting and Positron Annihilation Studies of Magnetic PVA/α-Fe2O3 Nanocomposites
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