8 research outputs found
Livelihood and vulnerability in the wake of Typhoon Yolanda: lessons of community and resilience
Livelihood strategies that are crafted in ‘extra-ordinary’ post-disaster conditions should
also be able to function once some semblance of normalcy has resumed. This article aims
to show that the vulnerability experienced in relation to Typhoon Yolanda was, and continues to be, directly linked to inadequate livelihood assets and opportunities. We examine the
extent to which various livelihood strategies lessened vulnerability post-Typhoon Yolanda
and argue that creating conditions under which disaster survivors have the freedom to pursue sustainable livelihood is essential in order to foster resilience and reduce vulnerability against future disasters. We offer suggestions to improve future relief efforts, including
suggestions made by the survivors themselves. We caution against rehabilitation strategies
that knowingly or unknowingly, resurrect pre-disaster vulnerability. Strategies that foster
dependency, fail to appreciate local political or ecological conditions or undermine cooperation and cohesion in already vulnerable communities will be bound to fail. Some of the
livelihood strategies that we observed post-Typhoon Yolanda failed on some or all of these
points. It is important for future policy that these failings are addressed
The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis
Sarcoplasmic reticulum calcium mishandling central tenet in heart failure?
Excitation-contraction coupling links excitation of the sarcolemmal surface membrane to mechanical contraction. In the heart this link is established via a Ca-induced Ca release process, which, following sarcolemmal depolarisation, prompts Ca release from the sarcoplasmic reticulum (SR)\ua0though the ryanodine receptor (RyR2). This substantially raises the cytoplasmic Ca concentration to trigger systole. In diastole, Ca is removed from the cytoplasm, primarily via the sarcoplasmic-endoplasmic reticulum Ca-dependent ATPase (SERCA) pump on the SR\ua0membrane, returning Ca to the SR store. Ca movement across the SR is thus fundamental to the systole/diastole cycle and plays an essential role in maintaining cardiac contractile function. Altered SR Ca homeostasis (due to disrupted Ca release, storage, and reuptake pathways) is a central tenet of heart failure and contributes to depressed contractility, impaired relaxation, and propensity to arrhythmia. This review will focus on the molecular mechanisms that underlie asynchronous Ca cycling around the SR in the failing heart. Further, this review will illustrate that the combined effects of expression changes and disruptions to RyR2 and SERCA2a regulatory pathways are critical to the pathogenesis of heart failure