Identification of novel metabolite and its cytotoxic effect on human lymphocyte cells in comparison to other mycotoxins

A novel metabolite of P. polonicum was recently isolated from Cameroonian Zea mays by means of preparative silica gel thin layer chromatographic method. The potential cytotoxic effects of this novelcompound was further tested, in vitro, against cultured human mononuclear lymphocyte cells over 18-hr period in comparison to ochratoxin A and T-2 toxin. At low concentrations (0.15, 0.31 and 0.63 μg/ml), the toxicity of the novel metabolite was similar to that of T-2 toxin, but was found to be significantly (

Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells

Context: Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium verticillioides (Sacc.) Nirenberg (Nectriaceae) mold that contaminates maize and other agricultural products. Although the effects of FB1 on sphingolipid metabolism are clear, little is known about early molecular changes associated with FB1 carcinogenicity